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Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae).
Nat Prod Res. 2012; 26(18):1682-6.NP

Abstract

An activity-guided isolation and purification process was used to identify the DPPH (l,l-diphenyl-2-picrylhydrazyl) radical-scavenging components of Swertia chirayita. A dry, whole plant of S. chirayita was extracted with different solvents and tested for its DPPH radical-scavenging activity. The acetone : water (8 : 2) extract showed the highest total phenolic content (TPC) and DPPH radical-scavenging activity, which was column chromatographed to obtain decussatin, swertianin, bellidifolin, isobellidifolin, amarogentin, swertianolin and mangiferin as active components. Good correlation was observed between TPC and DPPH scavenging activity among the extracts. The unique structure of xanthones, including the catecholic moiety and the completely conjugated system, enables them to be promising antioxidants.

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Authors+Show Affiliations

Singh PP
Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India.
Ambika
No affiliation info available
Chauhan SM
No affiliation info available

MeSH

AntioxidantsFree Radical ScavengersPlant ExtractsSwertiaXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21985644

Citation

Singh, Pradeep Pratap, et al. "Activity-guided Isolation of Antioxidant Xanthones From Swertia Chirayita (Roxb.) H. Karsten (Gentianaceae)." Natural Product Research, vol. 26, no. 18, 2012, pp. 1682-6.
Singh PP, Ambika , Chauhan SM. Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). Nat Prod Res. 2012;26(18):1682-6.
Singh, P. P., Ambika, ., & Chauhan, S. M. (2012). Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). Natural Product Research, 26(18), 1682-6. https://doi.org/10.1080/14786419.2011.592836
Singh PP, Ambika , Chauhan SM. Activity-guided Isolation of Antioxidant Xanthones From Swertia Chirayita (Roxb.) H. Karsten (Gentianaceae). Nat Prod Res. 2012;26(18):1682-6. PubMed PMID: 21985644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). AU - Singh,Pradeep Pratap, AU - Ambika,, AU - Chauhan,Shive Murat Singh, Y1 - 2011/10/10/ PY - 2011/10/12/entrez PY - 2011/10/12/pubmed PY - 2012/12/15/medline SP - 1682 EP - 6 JF - Natural product research JO - Nat Prod Res VL - 26 IS - 18 N2 - An activity-guided isolation and purification process was used to identify the DPPH (l,l-diphenyl-2-picrylhydrazyl) radical-scavenging components of Swertia chirayita. A dry, whole plant of S. chirayita was extracted with different solvents and tested for its DPPH radical-scavenging activity. The acetone : water (8 : 2) extract showed the highest total phenolic content (TPC) and DPPH radical-scavenging activity, which was column chromatographed to obtain decussatin, swertianin, bellidifolin, isobellidifolin, amarogentin, swertianolin and mangiferin as active components. Good correlation was observed between TPC and DPPH scavenging activity among the extracts. The unique structure of xanthones, including the catecholic moiety and the completely conjugated system, enables them to be promising antioxidants. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21985644/Activity_guided_isolation_of_antioxidant_xanthones_from_Swertia_chirayita__Roxb___H__Karsten__Gentianaceae__ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2011.592836 DB - PRIME DP - Unbound Medicine ER -