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Vitamin D status during pregnancy: maternal, fetal, and postnatal outcomes.
Curr Opin Obstet Gynecol. 2011 Dec; 23(6):422-6.CO

Abstract

PURPOSE OF REVIEW

To consider evidence from recent studies linking maternal vitamin D status during pregnancy with maternal, fetal, and postnatal outcomes.

RECENT FINDINGS

Several studies have demonstrated an association between poor maternal vitamin D status and severe preeclampsia, though results are inconsistent and cannot be generalized to nonsevere preeclampsia. Pregnant women with gestational diabetes, intrahepatic cholestasis of pregnancy, and periodontal disease had lower vitamin D status at mid-gestation or delivery compared with controls. Maternal vitamin D status early in pregnancy was associated with risk of low birth weight and small-for-gestational age infants in one study, whereas another study found this relation only among white women. Polymorphisms in the vitamin D receptor gene may contribute to vitamin D-related disparities in fetal growth. Evidence from recent studies suggests an early prenatal influence of maternal vitamin D status on fetal skeletal development, with lasting postnatal effects. Cord blood vitamin D status was associated with tolerogenic immune regulation and fewer respiratory infections in the newborn.

SUMMARY

Recent evidence supports a role of maternal vitamin D status, particularly early in pregnancy, in modulating the risk of pregnancy complications and in sustaining fetal growth, bone development, and immune maturation.

Authors+Show Affiliations

USDA, ARS Western Human Nutrition Research Center, Davis, California 95616, USA. daphnadror@gmail.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21986726

Citation

Dror, Daphna K.. "Vitamin D Status During Pregnancy: Maternal, Fetal, and Postnatal Outcomes." Current Opinion in Obstetrics & Gynecology, vol. 23, no. 6, 2011, pp. 422-6.
Dror DK. Vitamin D status during pregnancy: maternal, fetal, and postnatal outcomes. Curr Opin Obstet Gynecol. 2011;23(6):422-6.
Dror, D. K. (2011). Vitamin D status during pregnancy: maternal, fetal, and postnatal outcomes. Current Opinion in Obstetrics & Gynecology, 23(6), 422-6. https://doi.org/10.1097/GCO.0b013e32834cb791
Dror DK. Vitamin D Status During Pregnancy: Maternal, Fetal, and Postnatal Outcomes. Curr Opin Obstet Gynecol. 2011;23(6):422-6. PubMed PMID: 21986726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status during pregnancy: maternal, fetal, and postnatal outcomes. A1 - Dror,Daphna K, PY - 2011/10/12/entrez PY - 2011/10/12/pubmed PY - 2012/1/18/medline SP - 422 EP - 6 JF - Current opinion in obstetrics & gynecology JO - Curr Opin Obstet Gynecol VL - 23 IS - 6 N2 - PURPOSE OF REVIEW: To consider evidence from recent studies linking maternal vitamin D status during pregnancy with maternal, fetal, and postnatal outcomes. RECENT FINDINGS: Several studies have demonstrated an association between poor maternal vitamin D status and severe preeclampsia, though results are inconsistent and cannot be generalized to nonsevere preeclampsia. Pregnant women with gestational diabetes, intrahepatic cholestasis of pregnancy, and periodontal disease had lower vitamin D status at mid-gestation or delivery compared with controls. Maternal vitamin D status early in pregnancy was associated with risk of low birth weight and small-for-gestational age infants in one study, whereas another study found this relation only among white women. Polymorphisms in the vitamin D receptor gene may contribute to vitamin D-related disparities in fetal growth. Evidence from recent studies suggests an early prenatal influence of maternal vitamin D status on fetal skeletal development, with lasting postnatal effects. Cord blood vitamin D status was associated with tolerogenic immune regulation and fewer respiratory infections in the newborn. SUMMARY: Recent evidence supports a role of maternal vitamin D status, particularly early in pregnancy, in modulating the risk of pregnancy complications and in sustaining fetal growth, bone development, and immune maturation. SN - 1473-656X UR - https://www.unboundmedicine.com/medline/citation/21986726/Vitamin_D_status_during_pregnancy:_maternal_fetal_and_postnatal_outcomes_ L2 - https://doi.org/10.1097/GCO.0b013e32834cb791 DB - PRIME DP - Unbound Medicine ER -