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Vitamin D and multiple sclerosis: review of a possible association.
J Pharm Pract 2012; 25(1):75-84JP

Abstract

There has been growing interest in determining environmental risk factors that may play a role in the development or progression of multiple sclerosis (MS). Epidemiological evidence and data from human and animal studies have shown an association between low serum vitamin D levels and an increased incidence of MS and that supplementation with vitamin D may protect against MS development and/or disease relapses. The most appropriate vitamin D dosage for patients with MS is unclear, but investigator shave proposed that serum vitamin D concentrations between 75 and 100 nmol/L (30-40 ng/mL) are optimal to achieve favor able clinical outcomes. Vitamin D supplemented in doses up to 3000 International Units (IU) daily may be necessary to achieve these levels in many patients, and doses of 500 to 800 IU daily appear to be necessary to maintain desired serum vitamin D levels.Short-term supplementation with doses up to 40 000 IU daily has been found to be safe. However, larger and longer clinical studies are needed to assess whether a true relationship exists between serum vitamin D concentrations and MS and to determine a safe and effective amount of vitamin D supplementation.

Authors+Show Affiliations

Community Medical Center, Department of Pharmacy, Missoula, MT, USA. nsummerday@communitymed.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21987526

Citation

Summerday, Nicole Marie, et al. "Vitamin D and Multiple Sclerosis: Review of a Possible Association." Journal of Pharmacy Practice, vol. 25, no. 1, 2012, pp. 75-84.
Summerday NM, Brown SJ, Allington DR, et al. Vitamin D and multiple sclerosis: review of a possible association. J Pharm Pract. 2012;25(1):75-84.
Summerday, N. M., Brown, S. J., Allington, D. R., & Rivey, M. P. (2012). Vitamin D and multiple sclerosis: review of a possible association. Journal of Pharmacy Practice, 25(1), pp. 75-84. doi:10.1177/0897190011421839.
Summerday NM, et al. Vitamin D and Multiple Sclerosis: Review of a Possible Association. J Pharm Pract. 2012;25(1):75-84. PubMed PMID: 21987526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and multiple sclerosis: review of a possible association. AU - Summerday,Nicole Marie, AU - Brown,Sherrill J, AU - Allington,Douglas R, AU - Rivey,Michael P, PY - 2011/10/12/entrez PY - 2011/10/12/pubmed PY - 2012/7/20/medline SP - 75 EP - 84 JF - Journal of pharmacy practice JO - J Pharm Pract VL - 25 IS - 1 N2 - There has been growing interest in determining environmental risk factors that may play a role in the development or progression of multiple sclerosis (MS). Epidemiological evidence and data from human and animal studies have shown an association between low serum vitamin D levels and an increased incidence of MS and that supplementation with vitamin D may protect against MS development and/or disease relapses. The most appropriate vitamin D dosage for patients with MS is unclear, but investigator shave proposed that serum vitamin D concentrations between 75 and 100 nmol/L (30-40 ng/mL) are optimal to achieve favor able clinical outcomes. Vitamin D supplemented in doses up to 3000 International Units (IU) daily may be necessary to achieve these levels in many patients, and doses of 500 to 800 IU daily appear to be necessary to maintain desired serum vitamin D levels.Short-term supplementation with doses up to 40 000 IU daily has been found to be safe. However, larger and longer clinical studies are needed to assess whether a true relationship exists between serum vitamin D concentrations and MS and to determine a safe and effective amount of vitamin D supplementation. SN - 1531-1937 UR - https://www.unboundmedicine.com/medline/citation/21987526/Vitamin_D_and_multiple_sclerosis:_review_of_a_possible_association_ L2 - http://journals.sagepub.com/doi/full/10.1177/0897190011421839?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -