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Cysteine homeostasis plays an essential role in plant immunity.
New Phytol 2012; 193(1):165-77NP

Abstract

• Cysteine is the metabolic precursor of essential biomolecules such as vitamins, cofactors, antioxidants and many defense compounds. The last step of cysteine metabolism is catalysed by O-acetylserine(thiol)lyase (OASTL), which incorporates reduced sulfur into O-acetylserine to produce cysteine. In Arabidopsis thaliana, the main OASTL isoform OAS-A1 and the cytosolic desulfhydrase DES1, which degrades cysteine, contribute to the cytosolic cysteine homeostasis. • Meta-analysis of the transcriptomes of knockout plants for OAS-A1 and for DES1 show a high correlation with the biotic stress series in both cases. • The study of the response of knockout mutants to plant pathogens shows that des1 mutants behave as constitutive systemic acquired resistance mutants, with high resistance to biotrophic and necrotrophic pathogens, salicylic acid accumulation and WRKY54 and PR1 induction, while oas-a1 knockout mutants are more sensitive to biotrophic and necrotrophic pathogens. However, oas-a1 knockout mutants lack the hypersensitive response associated with the effector-triggered immunity elicited by Pseudomonas syringae pv. tomato DC3000 avrRpm1. • Our results highlight the role of cysteine as a crucial metabolite in the plant immune response.

Authors+Show Affiliations

Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Científicas and Universidad de Sevilla, Avda. Américo Vespucio, 49, ES-41092 Sevilla, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21988475

Citation

Álvarez, Consolación, et al. "Cysteine Homeostasis Plays an Essential Role in Plant Immunity." The New Phytologist, vol. 193, no. 1, 2012, pp. 165-77.
Álvarez C, Bermúdez MÁ, Romero LC, et al. Cysteine homeostasis plays an essential role in plant immunity. New Phytol. 2012;193(1):165-77.
Álvarez, C., Bermúdez, M. Á., Romero, L. C., Gotor, C., & García, I. (2012). Cysteine homeostasis plays an essential role in plant immunity. The New Phytologist, 193(1), pp. 165-77. doi:10.1111/j.1469-8137.2011.03889.x.
Álvarez C, et al. Cysteine Homeostasis Plays an Essential Role in Plant Immunity. New Phytol. 2012;193(1):165-77. PubMed PMID: 21988475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cysteine homeostasis plays an essential role in plant immunity. AU - Álvarez,Consolación, AU - Bermúdez,M Ángeles, AU - Romero,Luis C, AU - Gotor,Cecilia, AU - García,Irene, Y1 - 2011/10/11/ PY - 2011/10/13/entrez PY - 2011/10/13/pubmed PY - 2012/4/3/medline SP - 165 EP - 77 JF - The New phytologist JO - New Phytol. VL - 193 IS - 1 N2 - • Cysteine is the metabolic precursor of essential biomolecules such as vitamins, cofactors, antioxidants and many defense compounds. The last step of cysteine metabolism is catalysed by O-acetylserine(thiol)lyase (OASTL), which incorporates reduced sulfur into O-acetylserine to produce cysteine. In Arabidopsis thaliana, the main OASTL isoform OAS-A1 and the cytosolic desulfhydrase DES1, which degrades cysteine, contribute to the cytosolic cysteine homeostasis. • Meta-analysis of the transcriptomes of knockout plants for OAS-A1 and for DES1 show a high correlation with the biotic stress series in both cases. • The study of the response of knockout mutants to plant pathogens shows that des1 mutants behave as constitutive systemic acquired resistance mutants, with high resistance to biotrophic and necrotrophic pathogens, salicylic acid accumulation and WRKY54 and PR1 induction, while oas-a1 knockout mutants are more sensitive to biotrophic and necrotrophic pathogens. However, oas-a1 knockout mutants lack the hypersensitive response associated with the effector-triggered immunity elicited by Pseudomonas syringae pv. tomato DC3000 avrRpm1. • Our results highlight the role of cysteine as a crucial metabolite in the plant immune response. SN - 1469-8137 UR - https://www.unboundmedicine.com/medline/citation/21988475/Cysteine_homeostasis_plays_an_essential_role_in_plant_immunity_ L2 - https://doi.org/10.1111/j.1469-8137.2011.03889.x DB - PRIME DP - Unbound Medicine ER -