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Glutinoin, a novel antioxidative ellagitannin from Alnus glutinosa cones with glutinoic acid dilactone moiety.
Nat Prod Res. 2012; 26(19):1806-16.NP

Abstract

The crude aqueous ethanol extract of the cones of Alnus glutinosa (L.) Gaertn. (Betulaceae; black alder, European alder) was obtained and further partitioned between water and various organic phases. The active water and butanol phases were subjected to assay-guided (DPPH) fractionation using repetitive RP HPLC until individual compounds were isolated. Their antioxidative activities, measured as SC₅₀ values, were evaluated. The chemical structures of the isolated compounds were elucidated with the help of mass spectroscopy, (1)H NMR technique, UV spectroscopy, and chemical approaches. One novel ellagitannin, glutinoin (2), along with two known compounds, pedunculagin (1) and praecoxin D (3), were isolated and found to contribute to antioxidative activity of the A. glutinosa cones extract. The activities (SC₅₀) of 1-3 were evaluated as 0.95 (1), 1.00 (2) and 1.01 µg mL⁻¹ (3). The scavenging effects of glutinoin (2) and praecoxin D (3) were reported for the first time.

Authors+Show Affiliations

Ajinomoto-Genetika Research Institute, 1-st Dorozhny pr. 1-1, Moscow 117545, Russian Federation.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21988712

Citation

Ivanov, Sergey A., et al. "Glutinoin, a Novel Antioxidative Ellagitannin From Alnus Glutinosa Cones With Glutinoic Acid Dilactone Moiety." Natural Product Research, vol. 26, no. 19, 2012, pp. 1806-16.
Ivanov SA, Nomura K, Malfanov IL, et al. Glutinoin, a novel antioxidative ellagitannin from Alnus glutinosa cones with glutinoic acid dilactone moiety. Nat Prod Res. 2012;26(19):1806-16.
Ivanov, S. A., Nomura, K., Malfanov, I. L., & Ptitsyn, L. R. (2012). Glutinoin, a novel antioxidative ellagitannin from Alnus glutinosa cones with glutinoic acid dilactone moiety. Natural Product Research, 26(19), 1806-16. https://doi.org/10.1080/14786419.2011.613387
Ivanov SA, et al. Glutinoin, a Novel Antioxidative Ellagitannin From Alnus Glutinosa Cones With Glutinoic Acid Dilactone Moiety. Nat Prod Res. 2012;26(19):1806-16. PubMed PMID: 21988712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glutinoin, a novel antioxidative ellagitannin from Alnus glutinosa cones with glutinoic acid dilactone moiety. AU - Ivanov,Sergey A, AU - Nomura,Kenzo, AU - Malfanov,Ilya L, AU - Ptitsyn,Leonid R, Y1 - 2011/10/11/ PY - 2011/10/13/entrez PY - 2011/10/13/pubmed PY - 2013/2/6/medline SP - 1806 EP - 16 JF - Natural product research JO - Nat Prod Res VL - 26 IS - 19 N2 - The crude aqueous ethanol extract of the cones of Alnus glutinosa (L.) Gaertn. (Betulaceae; black alder, European alder) was obtained and further partitioned between water and various organic phases. The active water and butanol phases were subjected to assay-guided (DPPH) fractionation using repetitive RP HPLC until individual compounds were isolated. Their antioxidative activities, measured as SC₅₀ values, were evaluated. The chemical structures of the isolated compounds were elucidated with the help of mass spectroscopy, (1)H NMR technique, UV spectroscopy, and chemical approaches. One novel ellagitannin, glutinoin (2), along with two known compounds, pedunculagin (1) and praecoxin D (3), were isolated and found to contribute to antioxidative activity of the A. glutinosa cones extract. The activities (SC₅₀) of 1-3 were evaluated as 0.95 (1), 1.00 (2) and 1.01 µg mL⁻¹ (3). The scavenging effects of glutinoin (2) and praecoxin D (3) were reported for the first time. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21988712/Glutinoin_a_novel_antioxidative_ellagitannin_from_Alnus_glutinosa_cones_with_glutinoic_acid_dilactone_moiety_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2011.613387 DB - PRIME DP - Unbound Medicine ER -