Tags

Type your tag names separated by a space and hit enter

Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis.
Pathol Oncol Res. 2012 Apr; 18(2):405-12.PO

Abstract

The ultimate aim of the present study was to exploring the chemopreventive efficacy of diosgenin on 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. The chemopreventive potential of diosgenin was evaluated by measuring the tumour incidence, tumour volume and tumour burden as well as analyzing the activities of detoxification agents, levels of lipid peroxidation byproducts and antioxidants status by specific colorimetric methods. Oral squamous cell carcinoma (OSCC) was developed in the buccal pouches of male Syrian golden hamsters by painting with 0.5% DMBA in liquid paraffin, thrice a week for 16 weeks. DMBA painted animals were indicating the morphological changes as depicted as hyperplasia, dysplasia and well-developed squamous cell carcinoma. Moreover, antioxidants and lipid peroxidation byproducts levels were drastically altered in DMBA painted hamsters. Oral administration of diosgenin (80 mg/kg bw) to DMBA painted hamsters on alternate days for 16 weeks significantly reduced the formation of oral tumour and normalized the above biochemical abnormalities. We conclude that the diosgenin is probably potent chemopreventive agent due to their antioxidant function in DMBA induced hamster buccal pouch carcinogenesis.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, 608 002, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21990007

Citation

Rajalingam, Kasinathan, et al. "Anti-tumour and Anti-oxidative Potential of Diosgenin Against 7, 12-dimethylbenz(a)anthracene Induced Experimental Oral Carcinogenesis." Pathology Oncology Research : POR, vol. 18, no. 2, 2012, pp. 405-12.
Rajalingam K, Sugunadevi G, Arokia Vijayaanand M, et al. Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis. Pathol Oncol Res. 2012;18(2):405-12.
Rajalingam, K., Sugunadevi, G., Arokia Vijayaanand, M., Kalaimathi, J., & Suresh, K. (2012). Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis. Pathology Oncology Research : POR, 18(2), 405-12. https://doi.org/10.1007/s12253-011-9460-1
Rajalingam K, et al. Anti-tumour and Anti-oxidative Potential of Diosgenin Against 7, 12-dimethylbenz(a)anthracene Induced Experimental Oral Carcinogenesis. Pathol Oncol Res. 2012;18(2):405-12. PubMed PMID: 21990007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis. AU - Rajalingam,Kasinathan, AU - Sugunadevi,Govindasamy, AU - Arokia Vijayaanand,Mariadoss, AU - Kalaimathi,Janakiraman, AU - Suresh,Kathiresan, Y1 - 2011/10/12/ PY - 2011/07/11/received PY - 2011/09/09/accepted PY - 2011/10/13/entrez PY - 2011/10/13/pubmed PY - 2012/8/1/medline SP - 405 EP - 12 JF - Pathology oncology research : POR JO - Pathol Oncol Res VL - 18 IS - 2 N2 - The ultimate aim of the present study was to exploring the chemopreventive efficacy of diosgenin on 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. The chemopreventive potential of diosgenin was evaluated by measuring the tumour incidence, tumour volume and tumour burden as well as analyzing the activities of detoxification agents, levels of lipid peroxidation byproducts and antioxidants status by specific colorimetric methods. Oral squamous cell carcinoma (OSCC) was developed in the buccal pouches of male Syrian golden hamsters by painting with 0.5% DMBA in liquid paraffin, thrice a week for 16 weeks. DMBA painted animals were indicating the morphological changes as depicted as hyperplasia, dysplasia and well-developed squamous cell carcinoma. Moreover, antioxidants and lipid peroxidation byproducts levels were drastically altered in DMBA painted hamsters. Oral administration of diosgenin (80 mg/kg bw) to DMBA painted hamsters on alternate days for 16 weeks significantly reduced the formation of oral tumour and normalized the above biochemical abnormalities. We conclude that the diosgenin is probably potent chemopreventive agent due to their antioxidant function in DMBA induced hamster buccal pouch carcinogenesis. SN - 1532-2807 UR - https://www.unboundmedicine.com/medline/citation/21990007/Anti_tumour_and_anti_oxidative_potential_of_diosgenin_against_7_12_dimethylbenz_a_anthracene_induced_experimental_oral_carcinogenesis_ L2 - https://doi.org/10.1007/s12253-011-9460-1 DB - PRIME DP - Unbound Medicine ER -