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Sexually dimorphic effects of cannabinoid compounds on emotion and cognition.

Abstract

This review addresses the issue of sex differences in the response to cannabinoid compounds focusing mainly on behaviors belonging to the cognitive and emotional sphere. Sexual dimorphism exists in the different components of the endocannabinoid system. Males seem to have higher CB1 receptor binding sites than females, but females seem to possess more efficient CB1 receptors. Differences between sexes have been also observed in the metabolic processing of THC, the main psychoactive ingredient of marijuana. The consistent dimorphism in the endocannabinoid system and THC metabolism may justify at least in part the different sensitivity observed between male and female animals in different behavioral paradigms concerning emotion and cognition after treatment with cannabinoid compounds. On the basis of these observations, we would like to emphasize the need of including females in basic research and to analyze results for sex differences in epidemiological studies.

Authors+Show Affiliations

Department of Structural and Functional Biology and Neuroscience Center, University of Insubria Busto Arsizio, Italy.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21991251

Citation

Rubino, Tiziana, and Daniela Parolaro. "Sexually Dimorphic Effects of Cannabinoid Compounds On Emotion and Cognition." Frontiers in Behavioral Neuroscience, vol. 5, 2011, p. 64.
Rubino T, Parolaro D. Sexually dimorphic effects of cannabinoid compounds on emotion and cognition. Front Behav Neurosci. 2011;5:64.
Rubino, T., & Parolaro, D. (2011). Sexually dimorphic effects of cannabinoid compounds on emotion and cognition. Frontiers in Behavioral Neuroscience, 5, p. 64. doi:10.3389/fnbeh.2011.00064.
Rubino T, Parolaro D. Sexually Dimorphic Effects of Cannabinoid Compounds On Emotion and Cognition. Front Behav Neurosci. 2011;5:64. PubMed PMID: 21991251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sexually dimorphic effects of cannabinoid compounds on emotion and cognition. AU - Rubino,Tiziana, AU - Parolaro,Daniela, Y1 - 2011/09/28/ PY - 2011/06/14/received PY - 2011/09/11/accepted PY - 2011/10/13/entrez PY - 2011/10/13/pubmed PY - 2011/10/13/medline KW - cannabinoid KW - cognition KW - emotionality KW - sex differences SP - 64 EP - 64 JF - Frontiers in behavioral neuroscience JO - Front Behav Neurosci VL - 5 N2 - This review addresses the issue of sex differences in the response to cannabinoid compounds focusing mainly on behaviors belonging to the cognitive and emotional sphere. Sexual dimorphism exists in the different components of the endocannabinoid system. Males seem to have higher CB1 receptor binding sites than females, but females seem to possess more efficient CB1 receptors. Differences between sexes have been also observed in the metabolic processing of THC, the main psychoactive ingredient of marijuana. The consistent dimorphism in the endocannabinoid system and THC metabolism may justify at least in part the different sensitivity observed between male and female animals in different behavioral paradigms concerning emotion and cognition after treatment with cannabinoid compounds. On the basis of these observations, we would like to emphasize the need of including females in basic research and to analyze results for sex differences in epidemiological studies. SN - 1662-5153 UR - https://www.unboundmedicine.com/medline/citation/21991251/abstract/Sexually_dimorphic_effects_of L2 - https://dx.doi.org/10.3389/fnbeh.2011.00064 DB - PRIME DP - Unbound Medicine ER -