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Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure.
PLoS One. 2011; 6(10):e25784.Plos

Abstract

BACKGROUND

Cardiac sympathetic afferent reflex (CSAR) contributes to sympathetic activation and angiotensin II (Ang II) in paraventricular nucleus (PVN) augments the CSAR in vagotomized (VT) and baroreceptor denervated (BD) rats with chronic heart failure (CHF). This study was designed to determine whether it is true in intact (INT) rats with CHF and to determine the effects of cardiac and baroreceptor afferents on the CSAR and sympathetic activity in CHF.

METHODOLOGY/PRINCIPAL FINDINGS

Sham-operated (Sham) or coronary ligation-induced CHF rats were respectively subjected to BD+VT, VT, cardiac sympathetic denervation (CSD) or INT. Under anesthesia, renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded, and the CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. Either CSAR or the responses of RSNA, MAP and CSAR to Ang II in PVN were enhanced in CHF rats treated with BD+VT, VT or INT. Treatment with VT or BD+VT potentiated the CSAR and the CSAR responses to Ang II in both Sham and CHF rats. Treatment with CSD reversed the capsaicin-induced RSNA and MAP changes and the CSAR responses to Ang II in both Sham and CHF rats, and reduced the RSNA and MAP responses to Ang II only in CHF rats.

CONCLUSIONS

The CSAR and the CSAR responses to Ang II in PVN are enhanced in intact CHF rats. Baroreceptor and vagal afferent activities inhibit CSAR and the CSAR responses to Ang II in intact Sham and CHF rats.

Authors+Show Affiliations

Department of Physiology, Nanjing Medical University, Nanjing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21991351

Citation

Gan, Xian-Bing, et al. "Inhibition of Cardiac Sympathetic Afferent Reflex and Sympathetic Activity By Baroreceptor and Vagal Afferent Inputs in Chronic Heart Failure." PloS One, vol. 6, no. 10, 2011, pp. e25784.
Gan XB, Duan YC, Xiong XQ, et al. Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure. PLoS ONE. 2011;6(10):e25784.
Gan, X. B., Duan, Y. C., Xiong, X. Q., Li, P., Cui, B. P., Gao, X. Y., & Zhu, G. Q. (2011). Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure. PloS One, 6(10), e25784. https://doi.org/10.1371/journal.pone.0025784
Gan XB, et al. Inhibition of Cardiac Sympathetic Afferent Reflex and Sympathetic Activity By Baroreceptor and Vagal Afferent Inputs in Chronic Heart Failure. PLoS ONE. 2011;6(10):e25784. PubMed PMID: 21991351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure. AU - Gan,Xian-Bing, AU - Duan,Yang-Can, AU - Xiong,Xiao-Qing, AU - Li,Peng, AU - Cui,Bai-Ping, AU - Gao,Xing-Ya, AU - Zhu,Guo-Qing, Y1 - 2011/10/03/ PY - 2011/07/01/received PY - 2011/09/09/accepted PY - 2011/10/13/entrez PY - 2011/10/13/pubmed PY - 2012/2/7/medline SP - e25784 EP - e25784 JF - PloS one JO - PLoS ONE VL - 6 IS - 10 N2 - BACKGROUND: Cardiac sympathetic afferent reflex (CSAR) contributes to sympathetic activation and angiotensin II (Ang II) in paraventricular nucleus (PVN) augments the CSAR in vagotomized (VT) and baroreceptor denervated (BD) rats with chronic heart failure (CHF). This study was designed to determine whether it is true in intact (INT) rats with CHF and to determine the effects of cardiac and baroreceptor afferents on the CSAR and sympathetic activity in CHF. METHODOLOGY/PRINCIPAL FINDINGS: Sham-operated (Sham) or coronary ligation-induced CHF rats were respectively subjected to BD+VT, VT, cardiac sympathetic denervation (CSD) or INT. Under anesthesia, renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded, and the CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. Either CSAR or the responses of RSNA, MAP and CSAR to Ang II in PVN were enhanced in CHF rats treated with BD+VT, VT or INT. Treatment with VT or BD+VT potentiated the CSAR and the CSAR responses to Ang II in both Sham and CHF rats. Treatment with CSD reversed the capsaicin-induced RSNA and MAP changes and the CSAR responses to Ang II in both Sham and CHF rats, and reduced the RSNA and MAP responses to Ang II only in CHF rats. CONCLUSIONS: The CSAR and the CSAR responses to Ang II in PVN are enhanced in intact CHF rats. Baroreceptor and vagal afferent activities inhibit CSAR and the CSAR responses to Ang II in intact Sham and CHF rats. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/21991351/Inhibition_of_cardiac_sympathetic_afferent_reflex_and_sympathetic_activity_by_baroreceptor_and_vagal_afferent_inputs_in_chronic_heart_failure_ L2 - http://dx.plos.org/10.1371/journal.pone.0025784 DB - PRIME DP - Unbound Medicine ER -