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Ondansetron and meperidine prevent postoperative shivering after general anesthesia.
Middle East J Anaesthesiol. 2011 Feb; 21(1):67-70.ME

Abstract

BACKGROUND

Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering.

METHODS

This randomized placebo-controlled double blind clinical trial included 90 patients scheduled for elective gynecologic operations, randomly divided to three groups. Ondansetron (4 mg), Meperidine (0.4 mg/kg) and 2 cc normal saline (as a control group) were administered immediately before the induction of anesthesia. Anesthesia induced equivalently for all. Patients were observed in terms of vital signs, side effects and shivering.

RESULTS

Postoperative shivering was observed in 13.3% of patients in Ondansetron group and 20% of Meperidine group, significantly lower than the controls (50%). The reduction of core and dermal temperature during the anesthesia and recovery, changes in systolic and diastolic blood pressure and heart rate were similar in all three groups. The incidence of nausea was similar among the three groups of study while vomiting occurred in 6.7% of the Meperidine group and 3.3% of the controls but none in the patients receiving Ondansetron.

CONCLUSION

Ondansetron can effectively reduce post operative shivering.

Authors+Show Affiliations

Ardebil University of Medical Sciences, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21991735

Citation

Asl, Masoud Entezari, et al. "Ondansetron and Meperidine Prevent Postoperative Shivering After General Anesthesia." Middle East Journal of Anaesthesiology, vol. 21, no. 1, 2011, pp. 67-70.
Asl ME, Isazadefar K, Mohammadian A, et al. Ondansetron and meperidine prevent postoperative shivering after general anesthesia. Middle East J Anaesthesiol. 2011;21(1):67-70.
Asl, M. E., Isazadefar, K., Mohammadian, A., & Khoshbaten, M. (2011). Ondansetron and meperidine prevent postoperative shivering after general anesthesia. Middle East Journal of Anaesthesiology, 21(1), 67-70.
Asl ME, et al. Ondansetron and Meperidine Prevent Postoperative Shivering After General Anesthesia. Middle East J Anaesthesiol. 2011;21(1):67-70. PubMed PMID: 21991735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ondansetron and meperidine prevent postoperative shivering after general anesthesia. AU - Asl,Masoud Entezari, AU - Isazadefar,Khatereh, AU - Mohammadian,Ali, AU - Khoshbaten,Manouchehr, PY - 2011/10/14/entrez PY - 2011/10/14/pubmed PY - 2011/10/26/medline SP - 67 EP - 70 JF - Middle East journal of anaesthesiology JO - Middle East J Anaesthesiol VL - 21 IS - 1 N2 - BACKGROUND: Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering. METHODS: This randomized placebo-controlled double blind clinical trial included 90 patients scheduled for elective gynecologic operations, randomly divided to three groups. Ondansetron (4 mg), Meperidine (0.4 mg/kg) and 2 cc normal saline (as a control group) were administered immediately before the induction of anesthesia. Anesthesia induced equivalently for all. Patients were observed in terms of vital signs, side effects and shivering. RESULTS: Postoperative shivering was observed in 13.3% of patients in Ondansetron group and 20% of Meperidine group, significantly lower than the controls (50%). The reduction of core and dermal temperature during the anesthesia and recovery, changes in systolic and diastolic blood pressure and heart rate were similar in all three groups. The incidence of nausea was similar among the three groups of study while vomiting occurred in 6.7% of the Meperidine group and 3.3% of the controls but none in the patients receiving Ondansetron. CONCLUSION: Ondansetron can effectively reduce post operative shivering. SN - 0544-0440 UR - https://www.unboundmedicine.com/medline/citation/21991735/Ondansetron_and_meperidine_prevent_postoperative_shivering_after_general_anesthesia_ L2 - https://medlineplus.gov/aftersurgery.html DB - PRIME DP - Unbound Medicine ER -