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Relations between steroids and AMH: impact of basal and intrafollicular steroids to AMH ratios on oocyte yield and maturation rate in women with or without polycystic ovary undergoing in vitro fertilization.
Gynecol Endocrinol. 2012 Jun; 28(6):413-7.GE

Abstract

OBJECTIVE

This study sought to determine the relationships between serum or intrafollicular ovarian steroids and anti-mullerian hormone (AMH) and to predict impact of steroids to AMH ratios on oocyte quantity and metaphase II (MII) oocyte rate in normo-ovulatory (control) and polycystic ovary syndrome (PCOS) patients.

DESIGN

Prospective study.

SETTING

University hospital and research center.

PATIENTS

Thirty-two patients with PCOS and 37 controls undergoing IVF-ET.

METHODS

Serum (day 3) and follicular fluid (FF) from more than one follicle ≥ 17 mm on the day of oocyte retrieval were collected from each patients.

MAIN OUTCOME MEASURES

Serum or follicular fluid steroids, AMH, retrieved oocytes number and maturation rate.

RESULTS

In control group, intrafollicular AMH levels were positively related to P4 and T levels (p = .002, p = .011, respectively). Multiple linear regression analysis showed serum basal AMH and T levels as independent positive predictors while T/AMH ratio and intrafollicular AMH were negative predictors for both retrieved and MII oocyte number. The presence of PCOS and intrafollicular P4/AMH ratio revealed as important negative factors influencing oocyte maturation rate.

CONCLUSIONS

Serum basal T, AMH as well as their ratio and intrafollicular P4/AMH ratio may be used as predictors for retrieved oocyte number and their nuclear maturation rate, respectively.

Authors+Show Affiliations

Department of Developmental Biology, School of Biology, University College of Science, University of Tehran, Tehran, Iran. ghossein@khayam.ut.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21992510

Citation

Hossein, Ghamartaj, et al. "Relations Between Steroids and AMH: Impact of Basal and Intrafollicular Steroids to AMH Ratios On Oocyte Yield and Maturation Rate in Women With or Without Polycystic Ovary Undergoing in Vitro Fertilization." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 28, no. 6, 2012, pp. 413-7.
Hossein G, Arabzadeh S, Hossein-Rashidi B, et al. Relations between steroids and AMH: impact of basal and intrafollicular steroids to AMH ratios on oocyte yield and maturation rate in women with or without polycystic ovary undergoing in vitro fertilization. Gynecol Endocrinol. 2012;28(6):413-7.
Hossein, G., Arabzadeh, S., Hossein-Rashidi, B., & Hosseini, M. A. (2012). Relations between steroids and AMH: impact of basal and intrafollicular steroids to AMH ratios on oocyte yield and maturation rate in women with or without polycystic ovary undergoing in vitro fertilization. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 28(6), 413-7. https://doi.org/10.3109/09513590.2011.613964
Hossein G, et al. Relations Between Steroids and AMH: Impact of Basal and Intrafollicular Steroids to AMH Ratios On Oocyte Yield and Maturation Rate in Women With or Without Polycystic Ovary Undergoing in Vitro Fertilization. Gynecol Endocrinol. 2012;28(6):413-7. PubMed PMID: 21992510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relations between steroids and AMH: impact of basal and intrafollicular steroids to AMH ratios on oocyte yield and maturation rate in women with or without polycystic ovary undergoing in vitro fertilization. AU - Hossein,Ghamartaj, AU - Arabzadeh,Somayeh, AU - Hossein-Rashidi,Batool, AU - Hosseini,Marziyeh Agha, Y1 - 2011/10/12/ PY - 2011/10/14/entrez PY - 2011/10/14/pubmed PY - 2012/9/14/medline SP - 413 EP - 7 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 28 IS - 6 N2 - OBJECTIVE: This study sought to determine the relationships between serum or intrafollicular ovarian steroids and anti-mullerian hormone (AMH) and to predict impact of steroids to AMH ratios on oocyte quantity and metaphase II (MII) oocyte rate in normo-ovulatory (control) and polycystic ovary syndrome (PCOS) patients. DESIGN: Prospective study. SETTING: University hospital and research center. PATIENTS: Thirty-two patients with PCOS and 37 controls undergoing IVF-ET. METHODS: Serum (day 3) and follicular fluid (FF) from more than one follicle ≥ 17 mm on the day of oocyte retrieval were collected from each patients. MAIN OUTCOME MEASURES: Serum or follicular fluid steroids, AMH, retrieved oocytes number and maturation rate. RESULTS: In control group, intrafollicular AMH levels were positively related to P4 and T levels (p = .002, p = .011, respectively). Multiple linear regression analysis showed serum basal AMH and T levels as independent positive predictors while T/AMH ratio and intrafollicular AMH were negative predictors for both retrieved and MII oocyte number. The presence of PCOS and intrafollicular P4/AMH ratio revealed as important negative factors influencing oocyte maturation rate. CONCLUSIONS: Serum basal T, AMH as well as their ratio and intrafollicular P4/AMH ratio may be used as predictors for retrieved oocyte number and their nuclear maturation rate, respectively. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/21992510/Relations_between_steroids_and_AMH:_impact_of_basal_and_intrafollicular_steroids_to_AMH_ratios_on_oocyte_yield_and_maturation_rate_in_women_with_or_without_polycystic_ovary_undergoing_in_vitro_fertilization_ DB - PRIME DP - Unbound Medicine ER -