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Probiotics in the treatment of human inflammatory bowel diseases: update 2011.
J Clin Gastroenterol 2011; 45 Suppl:S139-44JC

Abstract

Crohn's disease, ulcerative colitis, and pouchitis after ileal pouch anal anastomosis in ulcerative colitis patients are often refractory to standard therapy. Over the last decade, the rational to use probiotics and its beneficial efficacy in the treatment of chronic inflammatory bowel disease (IBD) is increasingly under scrutiny. Although it has become clear that intestinal epithelial-mucosal immune interactions and enteric bacteria play a critical role in the development of IBD, the substantial clinical efficacy of probiotics in these disorders is less evident. This review outlines the clinical studies regarding probiotics before October 2007. These studies formed the foundation of probiotic clinical trials in IBD, but they also indicated the need of larger and better-controlled studies than the past experimental approaches. Furthermore, this review also examines in-depth the probiotic clinical trials published between 2007 and December 2010, providing new insights into the role of probiotics for inducing and maintaining remission of IBD, and highlighting some of the breakthroughs, especially regarding induction of remission for ulcerative colitis.

Authors+Show Affiliations

Department of Medicine, Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21992953

Citation

Meijer, Bartolomeus Joannes, and Levinus Albert Dieleman. "Probiotics in the Treatment of Human Inflammatory Bowel Diseases: Update 2011." Journal of Clinical Gastroenterology, vol. 45 Suppl, 2011, pp. S139-44.
Meijer BJ, Dieleman LA. Probiotics in the treatment of human inflammatory bowel diseases: update 2011. J Clin Gastroenterol. 2011;45 Suppl:S139-44.
Meijer, B. J., & Dieleman, L. A. (2011). Probiotics in the treatment of human inflammatory bowel diseases: update 2011. Journal of Clinical Gastroenterology, 45 Suppl, pp. S139-44. doi:10.1097/MCG.0b013e31822103f7.
Meijer BJ, Dieleman LA. Probiotics in the Treatment of Human Inflammatory Bowel Diseases: Update 2011. J Clin Gastroenterol. 2011;45 Suppl:S139-44. PubMed PMID: 21992953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics in the treatment of human inflammatory bowel diseases: update 2011. AU - Meijer,Bartolomeus Joannes, AU - Dieleman,Levinus Albert, PY - 2011/10/14/entrez PY - 2011/10/14/pubmed PY - 2012/2/15/medline SP - S139 EP - 44 JF - Journal of clinical gastroenterology JO - J. Clin. Gastroenterol. VL - 45 Suppl N2 - Crohn's disease, ulcerative colitis, and pouchitis after ileal pouch anal anastomosis in ulcerative colitis patients are often refractory to standard therapy. Over the last decade, the rational to use probiotics and its beneficial efficacy in the treatment of chronic inflammatory bowel disease (IBD) is increasingly under scrutiny. Although it has become clear that intestinal epithelial-mucosal immune interactions and enteric bacteria play a critical role in the development of IBD, the substantial clinical efficacy of probiotics in these disorders is less evident. This review outlines the clinical studies regarding probiotics before October 2007. These studies formed the foundation of probiotic clinical trials in IBD, but they also indicated the need of larger and better-controlled studies than the past experimental approaches. Furthermore, this review also examines in-depth the probiotic clinical trials published between 2007 and December 2010, providing new insights into the role of probiotics for inducing and maintaining remission of IBD, and highlighting some of the breakthroughs, especially regarding induction of remission for ulcerative colitis. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/21992953/Probiotics_in_the_treatment_of_human_inflammatory_bowel_diseases:_update_2011_ L2 - http://Insights.ovid.com/pubmed?pmid=21992953 DB - PRIME DP - Unbound Medicine ER -