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The role of TRPA1 in visceral inflammation and pain.
Channels (Austin). 2011 Nov-Dec; 5(6):525-9.C

Abstract

Despite significant progress in our understanding of the cellular and molecular mechanisms underlying sensory transduction and nociception, clinical pain management remains a considerable challenge in health care and basic research. The identification of the superfamily of transient receptor potential (TRP) cation channels, particularly TRPV1 and TRPA1, has shed light on the molecular basis of pain signaling during inflammatory conditions. TRPV1 and TRPA1 are considered as potential targets in the treatment of inflammatory pain because of their ability to be activated by nociceptive signals and sensitized by pro-inflammatory mediators. Notably, TRPA1 is expressed in visceral afferent neurons and is known to participate in inflammatory responses and the establishment of hypersensitivity. This review summarizes the current knowledge of the role of TRPA1 in sensory transduction, particularly in the context of visceral inflammation and pain in the gastrointestinal and urinary tracts.

Authors+Show Affiliations

University of Calgary, AB, Canada.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21993194

Citation

Lapointe, Tamia K., and Christophe Altier. "The Role of TRPA1 in Visceral Inflammation and Pain." Channels (Austin, Tex.), vol. 5, no. 6, 2011, pp. 525-9.
Lapointe TK, Altier C. The role of TRPA1 in visceral inflammation and pain. Channels (Austin). 2011;5(6):525-9.
Lapointe, T. K., & Altier, C. (2011). The role of TRPA1 in visceral inflammation and pain. Channels (Austin, Tex.), 5(6), 525-9. https://doi.org/10.4161/chan.5.6.18016
Lapointe TK, Altier C. The Role of TRPA1 in Visceral Inflammation and Pain. Channels (Austin). 2011 Nov-Dec;5(6):525-9. PubMed PMID: 21993194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of TRPA1 in visceral inflammation and pain. AU - Lapointe,Tamia K, AU - Altier,Christophe, Y1 - 2011/11/01/ PY - 2011/10/14/entrez PY - 2011/10/14/pubmed PY - 2012/6/9/medline SP - 525 EP - 9 JF - Channels (Austin, Tex.) JO - Channels (Austin) VL - 5 IS - 6 N2 - Despite significant progress in our understanding of the cellular and molecular mechanisms underlying sensory transduction and nociception, clinical pain management remains a considerable challenge in health care and basic research. The identification of the superfamily of transient receptor potential (TRP) cation channels, particularly TRPV1 and TRPA1, has shed light on the molecular basis of pain signaling during inflammatory conditions. TRPV1 and TRPA1 are considered as potential targets in the treatment of inflammatory pain because of their ability to be activated by nociceptive signals and sensitized by pro-inflammatory mediators. Notably, TRPA1 is expressed in visceral afferent neurons and is known to participate in inflammatory responses and the establishment of hypersensitivity. This review summarizes the current knowledge of the role of TRPA1 in sensory transduction, particularly in the context of visceral inflammation and pain in the gastrointestinal and urinary tracts. SN - 1933-6969 UR - https://www.unboundmedicine.com/medline/citation/21993194/The_role_of_TRPA1_in_visceral_inflammation_and_pain_ L2 - https://www.tandfonline.com/doi/full/10.4161/chan.5.6.18016 DB - PRIME DP - Unbound Medicine ER -