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Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Am J Clin Nutr 2011; 94(5):1266-75AJ

Abstract

BACKGROUND

Gastric cancer (GC) is the second leading cause of cancer death worldwide. The association between alcohol consumption and GC has been investigated in numerous epidemiologic studies with inconsistent results.

OBJECTIVE

We evaluated the association between alcohol consumption and GC risk.

DESIGN

We conducted a prospective analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 444 cases of first primary gastric adenocarcinoma. HRs and 95% CIs for GC were estimated by using multivariable Cox proportional hazards regression for consumption of pure ethanol in grams per day, with stratification by smoking status, anatomic subsite (cardia, noncardia), and histologic subtype (diffuse, intestinal). In a subset of participants, results were further adjusted for baseline Helicobacter pylori serostatus.

RESULTS

Heavy (compared with very light) alcohol consumption (≥60 compared with 0.1-4.9 g/d) at baseline was positively associated with GC risk (HR: 1.65; 95% CI: 1.06, 2.58), whereas lower consumption amounts (<60 g/d) were not. When we analyzed GC risk by type of alcoholic beverage, there was a positive association for beer (≥30 g/d; HR: 1.75; 95% CI: 1.13, 2.73) but not for wine or liquor. Associations were primarily observed at the highest amounts of drinking in men and limited to noncardia subsite and intestinal histology; no statistically significant linear dose-response trends with GC risk were observed.

CONCLUSION

Heavy (but not light or moderate) consumption of alcohol at baseline (mainly from beer) is associated with intestinal-type noncardia GC risk in men from the EPIC cohort.

Authors+Show Affiliations

Unit of Nutrition, Environment and Cancer, Bellvitge Biomedical Research Institute-IDIBELL, Catalan Institute of Oncology-ICO, Barcelona, Spain. eduell@iconcologia.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21993435

Citation

Duell, Eric J., et al. "Alcohol Consumption and Gastric Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort." The American Journal of Clinical Nutrition, vol. 94, no. 5, 2011, pp. 1266-75.
Duell EJ, Travier N, Lujan-Barroso L, et al. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr. 2011;94(5):1266-75.
Duell, E. J., Travier, N., Lujan-Barroso, L., Clavel-Chapelon, F., Boutron-Ruault, M. C., Morois, S., ... González, C. A. (2011). Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The American Journal of Clinical Nutrition, 94(5), pp. 1266-75. doi:10.3945/ajcn.111.012351.
Duell EJ, et al. Alcohol Consumption and Gastric Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort. Am J Clin Nutr. 2011;94(5):1266-75. PubMed PMID: 21993435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. AU - Duell,Eric J, AU - Travier,Noémie, AU - Lujan-Barroso,Leila, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie-Christine, AU - Morois,Sophie, AU - Palli,Domenico, AU - Krogh,Vittorio, AU - Panico,Salvatore, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Quirós,J Ramón, AU - Sánchez-Cantalejo,Emilio, AU - Navarro,Carmen, AU - Gurrea,Aurelio Barricarte, AU - Dorronsoro,Miren, AU - Khaw,Kay-Tee, AU - Allen,Naomi E, AU - Key,Timothy J, AU - Bueno-de-Mesquita,H Bas, AU - Ros,Martine M, AU - Numans,Mattijs E, AU - Peeters,Petra H M, AU - Trichopoulou,Antonia, AU - Naska,Androniki, AU - Dilis,Vardis, AU - Teucher,Birgit, AU - Kaaks,Rudolf, AU - Boeing,Heiner, AU - Schütze,Madlen, AU - Regner,Sara, AU - Lindkvist,Björn, AU - Johansson,Ingegerd, AU - Hallmans,Göran, AU - Overvad,Kim, AU - Egeberg,Rikke, AU - Tjønneland,Anne, AU - Lund,Eiliv, AU - Weiderpass,Elisabete, AU - Braaten,Tonje, AU - Romieu,Isabelle, AU - Ferrari,Pietro, AU - Jenab,Mazda, AU - Stenling,Roger, AU - Aune,Dagfinn, AU - Norat,Teresa, AU - Riboli,Elio, AU - González,Carlos A, Y1 - 2011/10/12/ PY - 2011/10/14/entrez PY - 2011/10/14/pubmed PY - 2012/2/2/medline SP - 1266 EP - 75 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 5 N2 - BACKGROUND: Gastric cancer (GC) is the second leading cause of cancer death worldwide. The association between alcohol consumption and GC has been investigated in numerous epidemiologic studies with inconsistent results. OBJECTIVE: We evaluated the association between alcohol consumption and GC risk. DESIGN: We conducted a prospective analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 444 cases of first primary gastric adenocarcinoma. HRs and 95% CIs for GC were estimated by using multivariable Cox proportional hazards regression for consumption of pure ethanol in grams per day, with stratification by smoking status, anatomic subsite (cardia, noncardia), and histologic subtype (diffuse, intestinal). In a subset of participants, results were further adjusted for baseline Helicobacter pylori serostatus. RESULTS: Heavy (compared with very light) alcohol consumption (≥60 compared with 0.1-4.9 g/d) at baseline was positively associated with GC risk (HR: 1.65; 95% CI: 1.06, 2.58), whereas lower consumption amounts (<60 g/d) were not. When we analyzed GC risk by type of alcoholic beverage, there was a positive association for beer (≥30 g/d; HR: 1.75; 95% CI: 1.13, 2.73) but not for wine or liquor. Associations were primarily observed at the highest amounts of drinking in men and limited to noncardia subsite and intestinal histology; no statistically significant linear dose-response trends with GC risk were observed. CONCLUSION: Heavy (but not light or moderate) consumption of alcohol at baseline (mainly from beer) is associated with intestinal-type noncardia GC risk in men from the EPIC cohort. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21993435/Alcohol_consumption_and_gastric_cancer_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__cohort_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.012351 DB - PRIME DP - Unbound Medicine ER -