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Cidofovir Activity against Poxvirus Infections.
Viruses 2010; 2(12):2803-30V

Abstract

Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC] is an acyclic nucleoside analog approved since 1996 for clinical use in the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Cidofovir (CDV) has broad-spectrum activity against DNA viruses, including herpes-, adeno-, polyoma-, papilloma- and poxviruses. Among poxviruses, cidofovir has shown in vitro activity against orthopox [vaccinia, variola (smallpox), cowpox, monkeypox, camelpox, ectromelia], molluscipox [molluscum contagiosum] and parapox [orf] viruses. The anti-poxvirus activity of cidofovir in vivo has been shown in different models of infection when the compound was administered either intraperitoneal, intranasal (aerosolized) or topically. In humans, cidofovir has been successfully used for the treatment of recalcitrant molluscum contagiosum virus and orf virus in immunocompromised patients. CDV remains a reference compound against poxviruses and holds potential for the therapy and short-term prophylaxis of not only orthopox- but also parapox- and molluscipoxvirus infections.

Authors+Show Affiliations

Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KULeuven, Minderboredersstraat 10, B-3000 Leuven, Belgium; E-Mail: robert.snocek@rega.kuleuven.be.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21994641

Citation

Andrei, Graciela, and Robert Snoeck. "Cidofovir Activity Against Poxvirus Infections." Viruses, vol. 2, no. 12, 2010, pp. 2803-30.
Andrei G, Snoeck R. Cidofovir Activity against Poxvirus Infections. Viruses. 2010;2(12):2803-30.
Andrei, G., & Snoeck, R. (2010). Cidofovir Activity against Poxvirus Infections. Viruses, 2(12), pp. 2803-30. doi:10.3390/v2122803.
Andrei G, Snoeck R. Cidofovir Activity Against Poxvirus Infections. Viruses. 2010;2(12):2803-30. PubMed PMID: 21994641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cidofovir Activity against Poxvirus Infections. AU - Andrei,Graciela, AU - Snoeck,Robert, Y1 - 2010/12/22/ PY - 2010/11/10/received PY - 2010/12/09/revised PY - 2010/12/10/accepted PY - 2011/10/14/entrez PY - 2011/10/14/pubmed PY - 2011/10/14/medline KW - acyclic nucleoside analog KW - cidofovir KW - poxviruses SP - 2803 EP - 30 JF - Viruses JO - Viruses VL - 2 IS - 12 N2 - Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC] is an acyclic nucleoside analog approved since 1996 for clinical use in the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. Cidofovir (CDV) has broad-spectrum activity against DNA viruses, including herpes-, adeno-, polyoma-, papilloma- and poxviruses. Among poxviruses, cidofovir has shown in vitro activity against orthopox [vaccinia, variola (smallpox), cowpox, monkeypox, camelpox, ectromelia], molluscipox [molluscum contagiosum] and parapox [orf] viruses. The anti-poxvirus activity of cidofovir in vivo has been shown in different models of infection when the compound was administered either intraperitoneal, intranasal (aerosolized) or topically. In humans, cidofovir has been successfully used for the treatment of recalcitrant molluscum contagiosum virus and orf virus in immunocompromised patients. CDV remains a reference compound against poxviruses and holds potential for the therapy and short-term prophylaxis of not only orthopox- but also parapox- and molluscipoxvirus infections. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/21994641/Cidofovir_Activity_against_Poxvirus_Infections_ L2 - http://www.mdpi.com/resolver?pii=v2122803 DB - PRIME DP - Unbound Medicine ER -