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Another really, really big virus.
Viruses. 2011 Jan; 3(1):32-46.V

Abstract

Viruses with genomes larger than 300 kb and up to 1.2 Mb, which encode hundreds of proteins, are being discovered and characterized with increasing frequency. Most, but not all, of these large viruses (often referred to as giruses) infect protists that live in aqueous environments. Bioinformatic analyses of metagenomes of aqueous samples indicate that large DNA viruses are quite common in nature and await discovery. One issue that is perhaps not appreciated by the virology community is that large viruses, even those classified in the same family, can differ significantly in morphology, lifestyle, and gene complement. This brief commentary, which will mention some of these unique properties, was stimulated by the characterization of the newest member of this club, virus CroV (Fischer, M.G.; Allen, M.J.; Wilson, W.H.; Suttle, C.A. Giant virus with a remarkable complement of genes infects marine zooplankton. Proc. Natl. Acad. Sci. USA 2010, 107, 19508-19513). CroV has a 730 kb genome (with ∼544 protein-encoding genes) and infects the marine microzooplankton Cafeteria roenbergensis producing a lytic infection.

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Authors+Show Affiliations

Van Etten JL
Department of Plant Pathology, Nebraska Center for Virology, 205 Morrison Hall, University of Nebraska, Lincoln, NE 68583, USA.

MeSH

AnimalsComputational BiologyDNA VirusesDNA, ViralEvolution, MolecularGenome, ViralHumansPhylogenyViral ProteinsZooplankton

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21994725

Citation

Van Etten, James L.. "Another Really, Really Big Virus." Viruses, vol. 3, no. 1, 2011, pp. 32-46.
Van Etten JL. Another really, really big virus. Viruses. 2011;3(1):32-46.
Van Etten, J. L. (2011). Another really, really big virus. Viruses, 3(1), 32-46. https://doi.org/10.3390/v3010032
Van Etten JL. Another Really, Really Big Virus. Viruses. 2011;3(1):32-46. PubMed PMID: 21994725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Another really, really big virus. A1 - Van Etten,James L, Y1 - 2011/01/18/ PY - 2010/12/20/received PY - 2011/01/13/revised PY - 2011/01/14/accepted PY - 2011/10/14/entrez PY - 2011/10/14/pubmed PY - 2012/4/3/medline KW - NCLDV KW - giruses KW - huge viruses SP - 32 EP - 46 JF - Viruses JO - Viruses VL - 3 IS - 1 N2 - Viruses with genomes larger than 300 kb and up to 1.2 Mb, which encode hundreds of proteins, are being discovered and characterized with increasing frequency. Most, but not all, of these large viruses (often referred to as giruses) infect protists that live in aqueous environments. Bioinformatic analyses of metagenomes of aqueous samples indicate that large DNA viruses are quite common in nature and await discovery. One issue that is perhaps not appreciated by the virology community is that large viruses, even those classified in the same family, can differ significantly in morphology, lifestyle, and gene complement. This brief commentary, which will mention some of these unique properties, was stimulated by the characterization of the newest member of this club, virus CroV (Fischer, M.G.; Allen, M.J.; Wilson, W.H.; Suttle, C.A. Giant virus with a remarkable complement of genes infects marine zooplankton. Proc. Natl. Acad. Sci. USA 2010, 107, 19508-19513). CroV has a 730 kb genome (with ∼544 protein-encoding genes) and infects the marine microzooplankton Cafeteria roenbergensis producing a lytic infection. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/21994725/Another_really_really_big_virus_ L2 - https://www.mdpi.com/resolver?pii=v3010032 DB - PRIME DP - Unbound Medicine ER -