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Modulating oscillatory brain activity correlates of behavioral inhibition using transcranial direct current stimulation.
Clin Neurophysiol. 2012 May; 123(5):979-84.CN

Abstract

OBJECTIVE

Studies have mainly documented behavioral changes induced by transcranial direct current stimulation (tDCS), but recently cortical modulations of tDCS have also been investigated. Our previous work revealed behavioral inhibition modulation by anodal tDCS over the right inferior frontal gyrus (rIFG); however, the electrophysiological correlates underlying this stimulation montage have yet to be established. The current work aimed to evaluate the distribution of neuronal oscillations changes following anodal tDCS over rIFG coupled with cathodal tDCS over left orbitofrontal cortex (lOFC) using spectral power analysis.

METHODS

Healthy subjects underwent sham and real tDCS (15 min, 1.5 mA, anodal rIFG; cathodal lOFC) stimulation conditions in a single-blind, placebo-controlled cross-over trial. Following tDCS session, resting EEG recordings were collected during 15 min.

RESULTS

Analysis showed a significant and selective diminution of the power of theta band. The theta diminution was observed in the rIFG area (represented the anode electrode), and was not found in the lOFC area (represented the cathode electrode). A significant effect was observed only in the theta but not in other bands.

CONCLUSIONS

These results are the first demonstration of modulating oscillatory activity as measured by EEG with tDCS over rIFG in general, and documenting theta band reduction with this montage in particular.

SIGNIFICANCE

Our results may explain the improvement in behavioral inhibition reported in our previous work, and although this study was conducted with healthy subjects, the findings suggest that tDCS may also modulate electrophysiological changes among ADHD patients, where decreasing theta activity is the target of neuro-feedback methods aimed to improve cognitive control.

Authors+Show Affiliations

The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21995999

Citation

Jacobson, Liron, et al. "Modulating Oscillatory Brain Activity Correlates of Behavioral Inhibition Using Transcranial Direct Current Stimulation." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 123, no. 5, 2012, pp. 979-84.
Jacobson L, Ezra A, Berger U, et al. Modulating oscillatory brain activity correlates of behavioral inhibition using transcranial direct current stimulation. Clin Neurophysiol. 2012;123(5):979-84.
Jacobson, L., Ezra, A., Berger, U., & Lavidor, M. (2012). Modulating oscillatory brain activity correlates of behavioral inhibition using transcranial direct current stimulation. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 123(5), 979-84. https://doi.org/10.1016/j.clinph.2011.09.016
Jacobson L, et al. Modulating Oscillatory Brain Activity Correlates of Behavioral Inhibition Using Transcranial Direct Current Stimulation. Clin Neurophysiol. 2012;123(5):979-84. PubMed PMID: 21995999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulating oscillatory brain activity correlates of behavioral inhibition using transcranial direct current stimulation. AU - Jacobson,Liron, AU - Ezra,Adi, AU - Berger,Uri, AU - Lavidor,Michal, Y1 - 2011/10/12/ PY - 2011/04/09/received PY - 2011/09/14/revised PY - 2011/09/19/accepted PY - 2011/10/15/entrez PY - 2011/10/15/pubmed PY - 2012/5/11/medline SP - 979 EP - 84 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 123 IS - 5 N2 - OBJECTIVE: Studies have mainly documented behavioral changes induced by transcranial direct current stimulation (tDCS), but recently cortical modulations of tDCS have also been investigated. Our previous work revealed behavioral inhibition modulation by anodal tDCS over the right inferior frontal gyrus (rIFG); however, the electrophysiological correlates underlying this stimulation montage have yet to be established. The current work aimed to evaluate the distribution of neuronal oscillations changes following anodal tDCS over rIFG coupled with cathodal tDCS over left orbitofrontal cortex (lOFC) using spectral power analysis. METHODS: Healthy subjects underwent sham and real tDCS (15 min, 1.5 mA, anodal rIFG; cathodal lOFC) stimulation conditions in a single-blind, placebo-controlled cross-over trial. Following tDCS session, resting EEG recordings were collected during 15 min. RESULTS: Analysis showed a significant and selective diminution of the power of theta band. The theta diminution was observed in the rIFG area (represented the anode electrode), and was not found in the lOFC area (represented the cathode electrode). A significant effect was observed only in the theta but not in other bands. CONCLUSIONS: These results are the first demonstration of modulating oscillatory activity as measured by EEG with tDCS over rIFG in general, and documenting theta band reduction with this montage in particular. SIGNIFICANCE: Our results may explain the improvement in behavioral inhibition reported in our previous work, and although this study was conducted with healthy subjects, the findings suggest that tDCS may also modulate electrophysiological changes among ADHD patients, where decreasing theta activity is the target of neuro-feedback methods aimed to improve cognitive control. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/21995999/Modulating_oscillatory_brain_activity_correlates_of_behavioral_inhibition_using_transcranial_direct_current_stimulation_ DB - PRIME DP - Unbound Medicine ER -