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Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas.
Am J Surg. 2012 Jul; 204(1):44-8.AJ

Abstract

BACKGROUND

Frequency and characteristics of metachronous occurrence of multifocal intraductal papillary mucinous neoplasms (IPMNs) or distinct pancreatic ductal adenocarcinomas (PDACs) in the remnant pancreas during follow-up evaluation after pancreatectomy for IPMNs have not been well known. The aim of this study was to investigate the outcomes after resection of IPMNs, especially focusing on the metachronous occurrence of multifocal IPMNs and distinct PDACs.

METHODS

Medical records of 172 patients who underwent resection of IPMNs were reviewed retrospectively, and the data regarding the occurrence of metachronous IPMNs or PDACs in the remnant pancreas during a mean postoperative follow-up period of 64 months were collected.

RESULTS

The incidence including synchronous and metachronous multifocal occurrence of IPMNs was 20% (34 of 172), and that of distinct PDACs was 9.9% (17 of 172). Ten metachronous IPMNs developed in the remnant pancreas after a mean time of 23 postoperative months (range, 12-84 mo), and 2 with main duct IPMNs (both were carcinoma in situ) required remnant pancreatectomy. Six distinct PDACs developed in the remnant pancreas after a mean time of 84 postoperative months (range, 12-150 mo). Four of them were found to have a tumor with a size of less than 2 cm, whereas the remaining 2 PDACs were found to be unresectable more than 10 years after resection of IPMNs.

CONCLUSIONS

Intense long-term follow-up evaluation is necessary for the early detection of metachronous occurrence of distinct PDACs as well as malignant IPMNs after resection of IPMNs.

Authors+Show Affiliations

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21996346

Citation

Ohtsuka, Takao, et al. "Follow-up Study After Resection of Intraductal Papillary Mucinous Neoplasm of the Pancreas; Special References to the Multifocal Lesions and Development of Ductal Carcinoma in the Remnant Pancreas." American Journal of Surgery, vol. 204, no. 1, 2012, pp. 44-8.
Ohtsuka T, Kono H, Tanabe R, et al. Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas. Am J Surg. 2012;204(1):44-8.
Ohtsuka, T., Kono, H., Tanabe, R., Nagayoshi, Y., Mori, Y., Sadakari, Y., Takahata, S., Oda, Y., Aishima, S., Igarashi, H., Ito, T., Ishigami, K., Nakamura, M., Mizumoto, K., & Tanaka, M. (2012). Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas. American Journal of Surgery, 204(1), 44-8. https://doi.org/10.1016/j.amjsurg.2011.04.007
Ohtsuka T, et al. Follow-up Study After Resection of Intraductal Papillary Mucinous Neoplasm of the Pancreas; Special References to the Multifocal Lesions and Development of Ductal Carcinoma in the Remnant Pancreas. Am J Surg. 2012;204(1):44-8. PubMed PMID: 21996346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas. AU - Ohtsuka,Takao, AU - Kono,Hiroshi, AU - Tanabe,Reiko, AU - Nagayoshi,Yosuke, AU - Mori,Yasuhisa, AU - Sadakari,Yoshihiko, AU - Takahata,Shunichi, AU - Oda,Yasunori, AU - Aishima,Shinichi, AU - Igarashi,Hisato, AU - Ito,Tetsuhide, AU - Ishigami,Kousei, AU - Nakamura,Masafumi, AU - Mizumoto,Kazuhiro, AU - Tanaka,Masao, Y1 - 2011/10/13/ PY - 2011/01/18/received PY - 2011/04/04/revised PY - 2011/04/04/accepted PY - 2011/10/15/entrez PY - 2011/10/15/pubmed PY - 2012/8/16/medline SP - 44 EP - 8 JF - American journal of surgery JO - Am J Surg VL - 204 IS - 1 N2 - BACKGROUND: Frequency and characteristics of metachronous occurrence of multifocal intraductal papillary mucinous neoplasms (IPMNs) or distinct pancreatic ductal adenocarcinomas (PDACs) in the remnant pancreas during follow-up evaluation after pancreatectomy for IPMNs have not been well known. The aim of this study was to investigate the outcomes after resection of IPMNs, especially focusing on the metachronous occurrence of multifocal IPMNs and distinct PDACs. METHODS: Medical records of 172 patients who underwent resection of IPMNs were reviewed retrospectively, and the data regarding the occurrence of metachronous IPMNs or PDACs in the remnant pancreas during a mean postoperative follow-up period of 64 months were collected. RESULTS: The incidence including synchronous and metachronous multifocal occurrence of IPMNs was 20% (34 of 172), and that of distinct PDACs was 9.9% (17 of 172). Ten metachronous IPMNs developed in the remnant pancreas after a mean time of 23 postoperative months (range, 12-84 mo), and 2 with main duct IPMNs (both were carcinoma in situ) required remnant pancreatectomy. Six distinct PDACs developed in the remnant pancreas after a mean time of 84 postoperative months (range, 12-150 mo). Four of them were found to have a tumor with a size of less than 2 cm, whereas the remaining 2 PDACs were found to be unresectable more than 10 years after resection of IPMNs. CONCLUSIONS: Intense long-term follow-up evaluation is necessary for the early detection of metachronous occurrence of distinct PDACs as well as malignant IPMNs after resection of IPMNs. SN - 1879-1883 UR - https://www.unboundmedicine.com/medline/citation/21996346/Follow_up_study_after_resection_of_intraductal_papillary_mucinous_neoplasm_of_the_pancreas L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9610(11)00417-X DB - PRIME DP - Unbound Medicine ER -