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Aortic stenosis and angiodysplastic gastrointestinal bleeding: Heyde's disease.
Heart Lung. 2012 Jan-Feb; 41(1):90-4.HL

Abstract

Obscure gastrointestinal (GI) bleeding can be a perplexing and difficult problem in elderly patients, especially if they are hemodynamically unstable. If aortic stenosis is also present, the cause of the GI bleeding may be explained. We present a 66-year-old man with a medical history of coronary artery disease who presented with acute GI bleeding. During his hospital course, the patient had a colonoscopy showing diffuse angiodysplasia and an echocardiogram showing severe aortic stenosis. This combination of angiodysplasia and aortic stenosis is known as Heyde's syndrome. It has been hypothesized that the aortic stenosis causes an acquired von Willebrand factor deficiency that leads to GI bleeding. Aortic valve replacement, when possible, can prevent recurrent GI bleeding in these cases, but medical decisions in these cases are complex and difficult.

Authors+Show Affiliations

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA. sameer.islam@ttuhsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21996614

Citation

Islam, Sameer, et al. "Aortic Stenosis and Angiodysplastic Gastrointestinal Bleeding: Heyde's Disease." Heart & Lung : the Journal of Critical Care, vol. 41, no. 1, 2012, pp. 90-4.
Islam S, Islam E, Cevik C, et al. Aortic stenosis and angiodysplastic gastrointestinal bleeding: Heyde's disease. Heart Lung. 2012;41(1):90-4.
Islam, S., Islam, E., Cevik, C., Attaya, H., Otahbachi, M., & Nugent, K. (2012). Aortic stenosis and angiodysplastic gastrointestinal bleeding: Heyde's disease. Heart & Lung : the Journal of Critical Care, 41(1), 90-4. https://doi.org/10.1016/j.hrtlng.2010.07.004
Islam S, et al. Aortic Stenosis and Angiodysplastic Gastrointestinal Bleeding: Heyde's Disease. Heart Lung. 2012 Jan-Feb;41(1):90-4. PubMed PMID: 21996614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aortic stenosis and angiodysplastic gastrointestinal bleeding: Heyde's disease. AU - Islam,Sameer, AU - Islam,Ebtesam, AU - Cevik,Cihan, AU - Attaya,Hosam, AU - Otahbachi,Mohammad, AU - Nugent,Kenneth, Y1 - 2011/10/11/ PY - 2010/04/02/received PY - 2010/06/23/revised PY - 2010/07/17/accepted PY - 2011/10/15/entrez PY - 2011/10/15/pubmed PY - 2012/5/1/medline SP - 90 EP - 4 JF - Heart & lung : the journal of critical care JO - Heart Lung VL - 41 IS - 1 N2 - Obscure gastrointestinal (GI) bleeding can be a perplexing and difficult problem in elderly patients, especially if they are hemodynamically unstable. If aortic stenosis is also present, the cause of the GI bleeding may be explained. We present a 66-year-old man with a medical history of coronary artery disease who presented with acute GI bleeding. During his hospital course, the patient had a colonoscopy showing diffuse angiodysplasia and an echocardiogram showing severe aortic stenosis. This combination of angiodysplasia and aortic stenosis is known as Heyde's syndrome. It has been hypothesized that the aortic stenosis causes an acquired von Willebrand factor deficiency that leads to GI bleeding. Aortic valve replacement, when possible, can prevent recurrent GI bleeding in these cases, but medical decisions in these cases are complex and difficult. SN - 1527-3288 UR - https://www.unboundmedicine.com/medline/citation/21996614/Aortic_stenosis_and_angiodysplastic_gastrointestinal_bleeding:_Heyde's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-9563(10)00287-6 DB - PRIME DP - Unbound Medicine ER -