Tags

Type your tag names separated by a space and hit enter

Glucocorticoid antagonism by exercise and androgenic-anabolic steroids.
Med Sci Sports Exerc. 1990 Jun; 22(3):331-40.MS

Abstract

This work evaluated the anticatabolic capacity of androgenic-anabolic steroids and exercise (contractile activity) in inhibiting skeletal muscle atrophy associated with excessive levels of circulating glucocorticoids. With androgenic-anabolic steroids, most binding studies indicate that they have very low binding specificity for the glucocorticoid receptor. Androgens may interact through their own receptor to interfere with glucocorticoid functioning at the gene level, but this remains unproven. Current literature suggests that androgens do not prevent atrophy but may retard growth suppression accompanying glucocorticoid treatment. With exercise, functional overload, resistance, and endurance types of training are capable of preventing muscle atrophy from glucocorticoids. Androgen and glucocorticoid-receptor binding and glucocorticoid-receptor activation studies have, thus far, not established that atrophy prevention is mediated through the receptor. In conclusion, the role of androgenic-anabolic steroids as glucocorticoid antagonists requires further study. Study of the effects of exercise on muscle gene expression of glucocorticoid-inducible proteins is needed to gain additional understanding of this mechanism of atrophy prevention.

Authors+Show Affiliations

Department of Physical Education, University of Illinois, Chicago 60680.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

2199753

Citation

Hickson, R C., et al. "Glucocorticoid Antagonism By Exercise and Androgenic-anabolic Steroids." Medicine and Science in Sports and Exercise, vol. 22, no. 3, 1990, pp. 331-40.
Hickson RC, Czerwinski SM, Falduto MT, et al. Glucocorticoid antagonism by exercise and androgenic-anabolic steroids. Med Sci Sports Exerc. 1990;22(3):331-40.
Hickson, R. C., Czerwinski, S. M., Falduto, M. T., & Young, A. P. (1990). Glucocorticoid antagonism by exercise and androgenic-anabolic steroids. Medicine and Science in Sports and Exercise, 22(3), 331-40.
Hickson RC, et al. Glucocorticoid Antagonism By Exercise and Androgenic-anabolic Steroids. Med Sci Sports Exerc. 1990;22(3):331-40. PubMed PMID: 2199753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucocorticoid antagonism by exercise and androgenic-anabolic steroids. AU - Hickson,R C, AU - Czerwinski,S M, AU - Falduto,M T, AU - Young,A P, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 331 EP - 40 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 22 IS - 3 N2 - This work evaluated the anticatabolic capacity of androgenic-anabolic steroids and exercise (contractile activity) in inhibiting skeletal muscle atrophy associated with excessive levels of circulating glucocorticoids. With androgenic-anabolic steroids, most binding studies indicate that they have very low binding specificity for the glucocorticoid receptor. Androgens may interact through their own receptor to interfere with glucocorticoid functioning at the gene level, but this remains unproven. Current literature suggests that androgens do not prevent atrophy but may retard growth suppression accompanying glucocorticoid treatment. With exercise, functional overload, resistance, and endurance types of training are capable of preventing muscle atrophy from glucocorticoids. Androgen and glucocorticoid-receptor binding and glucocorticoid-receptor activation studies have, thus far, not established that atrophy prevention is mediated through the receptor. In conclusion, the role of androgenic-anabolic steroids as glucocorticoid antagonists requires further study. Study of the effects of exercise on muscle gene expression of glucocorticoid-inducible proteins is needed to gain additional understanding of this mechanism of atrophy prevention. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/2199753/Glucocorticoid_antagonism_by_exercise_and_androgenic_anabolic_steroids_ L2 - https://Insights.ovid.com/pubmed?pmid=2199753 DB - PRIME DP - Unbound Medicine ER -