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Dietary glycemic load and glycemic index and risk of coronary heart disease and stroke in Dutch men and women: the EPIC-MORGEN study.
PLoS One 2011; 6(10):e25955Plos

Abstract

BACKGROUND

The associations of glycemic load (GL) and glycemic index (GI) with the risk of cardiovascular diseases (CVD) are not well-established, particularly in men, and may be modified by gender.

OBJECTIVE

To assess whether high dietary GL and GI increase the risk of CVD in men and women.

METHODS

A large prospective cohort study (EPIC-MORGEN) was conducted within the general Dutch population among 8,855 men and 10,753 women, aged 21-64 years at baseline (1993-1997) and free of diabetes and CVD. Dietary intake was assessed with a validated food-frequency questionnaire and GI and GL were calculated using Foster-Powell's international table of GI. Information on morbidity and mortality was obtained through linkage with national registries. Cox proportional hazards analysis was performed to estimate hazard ratios (HRs) for incident coronary heart disease (CHD) and stroke, while adjusting for age, CVD risk factors, and dietary factors.

RESULTS

During a mean follow-up of 11.9 years, 581 CHD cases and 120 stroke cases occurred among men, and 300 CHD cases and 109 stroke cases occurred among women. In men, GL was associated with an increased CHD risk (adjusted HR per SD increase, 1.17 [95% CI, 1.02-1.35]), while no significant association was found in women (1.09 [0.89-1.33]). GI was not associated with CHD risk in both genders, while it was associated with increased stroke risk in men (1.27 [1.02-1.58]) but not in women (0.96 [0.75-1.22]). Similarly, total carbohydrate intake and starch intake were associated with a higher CHD risk in men (1.23 [1.04-1.46]; and 1.24 [1.07-1.45]), but not in women.

CONCLUSION

Among men, high GL and GI, and high carbohydrate and starch intake, were associated with increased risk of CVD.

Authors+Show Affiliations

National Institute for Public Health and the Environment, Bilthoven, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21998729

Citation

Burger, Koert N J., et al. "Dietary Glycemic Load and Glycemic Index and Risk of Coronary Heart Disease and Stroke in Dutch Men and Women: the EPIC-MORGEN Study." PloS One, vol. 6, no. 10, 2011, pp. e25955.
Burger KN, Beulens JW, Boer JM, et al. Dietary glycemic load and glycemic index and risk of coronary heart disease and stroke in Dutch men and women: the EPIC-MORGEN study. PLoS ONE. 2011;6(10):e25955.
Burger, K. N., Beulens, J. W., Boer, J. M., Spijkerman, A. M., & van der A, D. L. (2011). Dietary glycemic load and glycemic index and risk of coronary heart disease and stroke in Dutch men and women: the EPIC-MORGEN study. PloS One, 6(10), pp. e25955. doi:10.1371/journal.pone.0025955.
Burger KN, et al. Dietary Glycemic Load and Glycemic Index and Risk of Coronary Heart Disease and Stroke in Dutch Men and Women: the EPIC-MORGEN Study. PLoS ONE. 2011;6(10):e25955. PubMed PMID: 21998729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary glycemic load and glycemic index and risk of coronary heart disease and stroke in Dutch men and women: the EPIC-MORGEN study. AU - Burger,Koert N J, AU - Beulens,Joline W J, AU - Boer,Jolanda M A, AU - Spijkerman,Annemieke M W, AU - van der A,Daphne L, Y1 - 2011/10/05/ PY - 2011/06/30/received PY - 2011/09/14/accepted PY - 2011/10/15/entrez PY - 2011/10/15/pubmed PY - 2012/2/14/medline SP - e25955 EP - e25955 JF - PloS one JO - PLoS ONE VL - 6 IS - 10 N2 - BACKGROUND: The associations of glycemic load (GL) and glycemic index (GI) with the risk of cardiovascular diseases (CVD) are not well-established, particularly in men, and may be modified by gender. OBJECTIVE: To assess whether high dietary GL and GI increase the risk of CVD in men and women. METHODS: A large prospective cohort study (EPIC-MORGEN) was conducted within the general Dutch population among 8,855 men and 10,753 women, aged 21-64 years at baseline (1993-1997) and free of diabetes and CVD. Dietary intake was assessed with a validated food-frequency questionnaire and GI and GL were calculated using Foster-Powell's international table of GI. Information on morbidity and mortality was obtained through linkage with national registries. Cox proportional hazards analysis was performed to estimate hazard ratios (HRs) for incident coronary heart disease (CHD) and stroke, while adjusting for age, CVD risk factors, and dietary factors. RESULTS: During a mean follow-up of 11.9 years, 581 CHD cases and 120 stroke cases occurred among men, and 300 CHD cases and 109 stroke cases occurred among women. In men, GL was associated with an increased CHD risk (adjusted HR per SD increase, 1.17 [95% CI, 1.02-1.35]), while no significant association was found in women (1.09 [0.89-1.33]). GI was not associated with CHD risk in both genders, while it was associated with increased stroke risk in men (1.27 [1.02-1.58]) but not in women (0.96 [0.75-1.22]). Similarly, total carbohydrate intake and starch intake were associated with a higher CHD risk in men (1.23 [1.04-1.46]; and 1.24 [1.07-1.45]), but not in women. CONCLUSION: Among men, high GL and GI, and high carbohydrate and starch intake, were associated with increased risk of CVD. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/21998729/Dietary_glycemic_load_and_glycemic_index_and_risk_of_coronary_heart_disease_and_stroke_in_Dutch_men_and_women:_the_EPIC_MORGEN_study_ L2 - http://dx.plos.org/10.1371/journal.pone.0025955 DB - PRIME DP - Unbound Medicine ER -