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Vitamin D-gene interactions in multiple sclerosis.
J Neurol Sci 2011; 311(1-2):32-6JN

Abstract

Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.

Authors+Show Affiliations

Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22000399

Citation

Berlanga-Taylor, Antonio J., et al. "Vitamin D-gene Interactions in Multiple Sclerosis." Journal of the Neurological Sciences, vol. 311, no. 1-2, 2011, pp. 32-6.
Berlanga-Taylor AJ, Disanto G, Ebers GC, et al. Vitamin D-gene interactions in multiple sclerosis. J Neurol Sci. 2011;311(1-2):32-6.
Berlanga-Taylor, A. J., Disanto, G., Ebers, G. C., & Ramagopalan, S. V. (2011). Vitamin D-gene interactions in multiple sclerosis. Journal of the Neurological Sciences, 311(1-2), pp. 32-6. doi:10.1016/j.jns.2011.08.041.
Berlanga-Taylor AJ, et al. Vitamin D-gene Interactions in Multiple Sclerosis. J Neurol Sci. 2011 Dec 15;311(1-2):32-6. PubMed PMID: 22000399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D-gene interactions in multiple sclerosis. AU - Berlanga-Taylor,Antonio J, AU - Disanto,Giulio, AU - Ebers,George C, AU - Ramagopalan,Sreeram V, Y1 - 2011/10/13/ PY - 2011/05/10/received PY - 2011/08/23/revised PY - 2011/08/29/accepted PY - 2011/10/18/entrez PY - 2011/10/18/pubmed PY - 2012/9/1/medline SP - 32 EP - 6 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 311 IS - 1-2 N2 - Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/22000399/Vitamin_D_gene_interactions_in_multiple_sclerosis_ DB - PRIME DP - Unbound Medicine ER -