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A review of targeted ultraviolet B phototherapy for psoriasis.
J Am Acad Dermatol. 2012 Apr; 66(4):664-72.JA

Abstract

Targeted ultraviolet (UV) B phototherapy devices provide a practical means to treat localized psoriasis while sparing harmful effects to unaffected skin. The objective of this study was to characterize the efficacy and safety of targeted phototherapy devices for psoriasis. We conducted a PubMed search for broadband UVB, narrowband UVB, and localized phototherapy, and a Google search for handheld phototherapy. The most common targeted phototherapy devices were characterized as 308-nm excimer laser, 308-nm excimer nonlaser, or nonexcimer light subtypes. Nine clinical trials met inclusion criteria and all found targeted phototherapy efficacious. In a nonexcimer light study, high doses cleared the most plaques. The 308-nm excimer laser had long-term clearance in 13 of 26 patients. The mean number of UVB treatments in all 9 studies and highest cumulative dose was less than those same parameters in nontargeted phototherapies. Common adverse effects included erythema, blisters, hyperpigmentation, erosion, mild burning, and itching. The predominant setting for excimer units is the office; however, the majority of nonexcimer light devices can also be used at home. Targeted phototherapy should be considered among the treatment options for localized variants of psoriasis.

Authors+Show Affiliations

Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1071, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22000769

Citation

Mudigonda, Tejaswi, et al. "A Review of Targeted Ultraviolet B Phototherapy for Psoriasis." Journal of the American Academy of Dermatology, vol. 66, no. 4, 2012, pp. 664-72.
Mudigonda T, Dabade TS, Feldman SR. A review of targeted ultraviolet B phototherapy for psoriasis. J Am Acad Dermatol. 2012;66(4):664-72.
Mudigonda, T., Dabade, T. S., & Feldman, S. R. (2012). A review of targeted ultraviolet B phototherapy for psoriasis. Journal of the American Academy of Dermatology, 66(4), 664-72. https://doi.org/10.1016/j.jaad.2011.07.011
Mudigonda T, Dabade TS, Feldman SR. A Review of Targeted Ultraviolet B Phototherapy for Psoriasis. J Am Acad Dermatol. 2012;66(4):664-72. PubMed PMID: 22000769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of targeted ultraviolet B phototherapy for psoriasis. AU - Mudigonda,Tejaswi, AU - Dabade,Tushar S, AU - Feldman,Steven R, Y1 - 2011/10/14/ PY - 2011/01/30/received PY - 2011/07/13/revised PY - 2011/07/16/accepted PY - 2011/10/18/entrez PY - 2011/10/18/pubmed PY - 2012/5/9/medline SP - 664 EP - 72 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 66 IS - 4 N2 - Targeted ultraviolet (UV) B phototherapy devices provide a practical means to treat localized psoriasis while sparing harmful effects to unaffected skin. The objective of this study was to characterize the efficacy and safety of targeted phototherapy devices for psoriasis. We conducted a PubMed search for broadband UVB, narrowband UVB, and localized phototherapy, and a Google search for handheld phototherapy. The most common targeted phototherapy devices were characterized as 308-nm excimer laser, 308-nm excimer nonlaser, or nonexcimer light subtypes. Nine clinical trials met inclusion criteria and all found targeted phototherapy efficacious. In a nonexcimer light study, high doses cleared the most plaques. The 308-nm excimer laser had long-term clearance in 13 of 26 patients. The mean number of UVB treatments in all 9 studies and highest cumulative dose was less than those same parameters in nontargeted phototherapies. Common adverse effects included erythema, blisters, hyperpigmentation, erosion, mild burning, and itching. The predominant setting for excimer units is the office; however, the majority of nonexcimer light devices can also be used at home. Targeted phototherapy should be considered among the treatment options for localized variants of psoriasis. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/22000769/A_review_of_targeted_ultraviolet_B_phototherapy_for_psoriasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(11)00800-0 DB - PRIME DP - Unbound Medicine ER -