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HLA-DQ types of celiac disease in Libyan children with type 1 diabetes mellitus.
Eur J Gastroenterol Hepatol. 2012 Jan; 24(1):59-63.EJ

Abstract

OBJECTIVE

To determine the genetic profile of celiac disease (CD) in Libyan children with type 1 diabetes as there are no data on the frequency of human leukocyte antigen (HLA)-related CD-predisposing genes in diabetic patients in Libya.

METHODS

We randomly studied 218 Libyan type 1 diabetic children. The mean age was 12.2±4.6 years; 56% were female patients. The mean duration of diabetes was 4.7±4.0 years. All patients were screened for CD with IgA tissue-transglutaminase (tTG) and endomysium antibodies. Patients with positive immunological screen were programmed for a small-bowel biopsy. HLA-DRB1* and HLA-DQB1* were genotyped in all tTG-positive patients.

RESULTS

Twenty-seven (12.4%) out of 218 patients with type1 diabetes had positive tTG, and 20 (9.2%) of these patients were positive for endomysium antibodies. Five patients (5/27) were already known cases of biopsy-proven CD. Biopsy was not performed in two patients. One biopsy result was normal, whereas 19 biopsies demonstrated morphological changes consistent with CD. Forty-eight percent of the anti-tTG-positive group were homozygous for HLA-DQ2, whereas 75% of biopsy-proven CD patients had HLA-DQ2, 21% had HLA-DQ2/DQ8, and 4% had HLA-DQ8. In addition, the majority (70%) carried HLA-DQ2 linkage with HLA-DRB1*03.

CONCLUSION

Overall, biopsy-confirmed prevalence of CD was 11% (24 of 218). The present study confirms that CD in the Libyan type 1 diabetic population is high when compared with European and US studies, and for the first time we document that this population shares similar HLA-DQ2 genotype. This supports the theory regarding the role of the environment as an important factor in CD development in this part of the world.

Authors+Show Affiliations

Department of Pediatrics, DISM, University of Udine, Piazzale Santa Maria Delle Misericordia 15, Udine, Italy. ghamillad@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

22002004

Citation

Ghawil, Millad, et al. "HLA-DQ Types of Celiac Disease in Libyan Children With Type 1 Diabetes Mellitus." European Journal of Gastroenterology & Hepatology, vol. 24, no. 1, 2012, pp. 59-63.
Ghawil M, Miotti V, Tonutti E, et al. HLA-DQ types of celiac disease in Libyan children with type 1 diabetes mellitus. Eur J Gastroenterol Hepatol. 2012;24(1):59-63.
Ghawil, M., Miotti, V., Tonutti, E., Tenore, A., Hadeed, I., Sindici, C., Visentini, D., Morgham, A., & Abusrewil, S. (2012). HLA-DQ types of celiac disease in Libyan children with type 1 diabetes mellitus. European Journal of Gastroenterology & Hepatology, 24(1), 59-63. https://doi.org/10.1097/MEG.0b013e32834d09d4
Ghawil M, et al. HLA-DQ Types of Celiac Disease in Libyan Children With Type 1 Diabetes Mellitus. Eur J Gastroenterol Hepatol. 2012;24(1):59-63. PubMed PMID: 22002004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-DQ types of celiac disease in Libyan children with type 1 diabetes mellitus. AU - Ghawil,Millad, AU - Miotti,Valeria, AU - Tonutti,Elio, AU - Tenore,Alfred, AU - Hadeed,Ibtisam, AU - Sindici,Chiara, AU - Visentini,Daniela, AU - Morgham,Amel, AU - Abusrewil,Sulieman, PY - 2011/10/18/entrez PY - 2011/10/18/pubmed PY - 2012/2/18/medline SP - 59 EP - 63 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 24 IS - 1 N2 - OBJECTIVE: To determine the genetic profile of celiac disease (CD) in Libyan children with type 1 diabetes as there are no data on the frequency of human leukocyte antigen (HLA)-related CD-predisposing genes in diabetic patients in Libya. METHODS: We randomly studied 218 Libyan type 1 diabetic children. The mean age was 12.2±4.6 years; 56% were female patients. The mean duration of diabetes was 4.7±4.0 years. All patients were screened for CD with IgA tissue-transglutaminase (tTG) and endomysium antibodies. Patients with positive immunological screen were programmed for a small-bowel biopsy. HLA-DRB1* and HLA-DQB1* were genotyped in all tTG-positive patients. RESULTS: Twenty-seven (12.4%) out of 218 patients with type1 diabetes had positive tTG, and 20 (9.2%) of these patients were positive for endomysium antibodies. Five patients (5/27) were already known cases of biopsy-proven CD. Biopsy was not performed in two patients. One biopsy result was normal, whereas 19 biopsies demonstrated morphological changes consistent with CD. Forty-eight percent of the anti-tTG-positive group were homozygous for HLA-DQ2, whereas 75% of biopsy-proven CD patients had HLA-DQ2, 21% had HLA-DQ2/DQ8, and 4% had HLA-DQ8. In addition, the majority (70%) carried HLA-DQ2 linkage with HLA-DRB1*03. CONCLUSION: Overall, biopsy-confirmed prevalence of CD was 11% (24 of 218). The present study confirms that CD in the Libyan type 1 diabetic population is high when compared with European and US studies, and for the first time we document that this population shares similar HLA-DQ2 genotype. This supports the theory regarding the role of the environment as an important factor in CD development in this part of the world. SN - 1473-5687 UR - https://www.unboundmedicine.com/medline/citation/22002004/HLA_DQ_types_of_celiac_disease_in_Libyan_children_with_type_1_diabetes_mellitus_ L2 - http://dx.doi.org/10.1097/MEG.0b013e32834d09d4 DB - PRIME DP - Unbound Medicine ER -