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Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity.
Int J Rheum Dis 2011; 14(4):325-31IJ

Abstract

AIM

The present work was undertaken to study the status and contribution of oxidative stress in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients. Relationship of the markers of oxidative stress to clinical manifestations, disease activity, damage and medications used were well considered.

METHODS

Thirty SLE and 30 RA female patients were included in the study and clinical examination and investigations were performed and disease activity was assessed. Markers of oxidative stress, including malondialdehyde (MDA) and antioxidant scavengers with glutathione (GSH) and glutathione peroxidase (GSH Px) were assessed.

RESULTS

Level of MDA, GSH and GSH Px were remarkably altered in RA and SLE patients compared to controls. Markers of increased oxidative stress and impaired antioxidant capacity were profound in RA and significantly reflected disease activity in RA and SLE, with special attention to alopecia and lupus nephritis. RA patients receiving methotrexate had significantly altered parameters and the steroid dose in SLE patients correlated with these markers.

CONCLUSION

Oxidative stress was increased and more profound in RA than SLE and could well reflect disease activity, with special attention to SLE patients with alopecia and nephritis. Medications used are closely related to the oxidant/antioxidant imbalance. Considering antioxidants in novel therapeutic strategies is important in SLE and RA patients.

Authors+Show Affiliations

Department of Rheumatology, Faculty of Medicine, Cairo University, Cairo, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22004228

Citation

Hassan, Samia Z., et al. "Oxidative Stress in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients: Relationship to Disease Manifestations and Activity." International Journal of Rheumatic Diseases, vol. 14, no. 4, 2011, pp. 325-31.
Hassan SZ, Gheita TA, Kenawy SA, et al. Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity. Int J Rheum Dis. 2011;14(4):325-31.
Hassan, S. Z., Gheita, T. A., Kenawy, S. A., Fahim, A. T., El-Sorougy, I. M., & Abdou, M. S. (2011). Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity. International Journal of Rheumatic Diseases, 14(4), pp. 325-31. doi:10.1111/j.1756-185X.2011.01630.x.
Hassan SZ, et al. Oxidative Stress in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients: Relationship to Disease Manifestations and Activity. Int J Rheum Dis. 2011;14(4):325-31. PubMed PMID: 22004228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity. AU - Hassan,Samia Z, AU - Gheita,Tamer A, AU - Kenawy,Sanaa A, AU - Fahim,Atef T, AU - El-Sorougy,Iman M, AU - Abdou,Manal S, Y1 - 2011/07/21/ PY - 2011/10/19/entrez PY - 2011/10/19/pubmed PY - 2012/2/10/medline SP - 325 EP - 31 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 14 IS - 4 N2 - AIM: The present work was undertaken to study the status and contribution of oxidative stress in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients. Relationship of the markers of oxidative stress to clinical manifestations, disease activity, damage and medications used were well considered. METHODS: Thirty SLE and 30 RA female patients were included in the study and clinical examination and investigations were performed and disease activity was assessed. Markers of oxidative stress, including malondialdehyde (MDA) and antioxidant scavengers with glutathione (GSH) and glutathione peroxidase (GSH Px) were assessed. RESULTS: Level of MDA, GSH and GSH Px were remarkably altered in RA and SLE patients compared to controls. Markers of increased oxidative stress and impaired antioxidant capacity were profound in RA and significantly reflected disease activity in RA and SLE, with special attention to alopecia and lupus nephritis. RA patients receiving methotrexate had significantly altered parameters and the steroid dose in SLE patients correlated with these markers. CONCLUSION: Oxidative stress was increased and more profound in RA than SLE and could well reflect disease activity, with special attention to SLE patients with alopecia and nephritis. Medications used are closely related to the oxidant/antioxidant imbalance. Considering antioxidants in novel therapeutic strategies is important in SLE and RA patients. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/22004228/Oxidative_stress_in_systemic_lupus_erythematosus_and_rheumatoid_arthritis_patients:_relationship_to_disease_manifestations_and_activity_ L2 - https://doi.org/10.1111/j.1756-185X.2011.01630.x DB - PRIME DP - Unbound Medicine ER -