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Interaction between the basolateral amygdala and dorsal hippocampus is critical for cocaine memory reconsolidation and subsequent drug context-induced cocaine-seeking behavior in rats.
Learn Mem. 2011 Nov; 18(11):693-702.LM

Abstract

Contextual stimulus control over instrumental drug-seeking behavior relies on the reconsolidation of context-response-drug associative memories into long-term memory storage following retrieval-induced destabilization. According to previous studies, the basolateral amygdala (BLA) and dorsal hippocampus (DH) regulate cocaine-related memory reconsolidation; however, it is not known whether these brain regions interact or independently control this phenomenon. To investigate this question, rats were trained to lever press for cocaine reinforcement in a distinct environmental context followed by extinction training in a different context. Rats were then briefly re-exposed to the cocaine-paired context to destabilize cocaine-related memories, or they were exposed to an unpaired context. Immediately thereafter, the rats received unilateral microinfusions of anisomycin (ANI) into the BLA plus baclofen/muscimol (B/M) into the contralateral (BLA/DH disconnection) or ipsilateral DH, or they received contralateral or ipsilateral microinfusions of vehicle. They then remained in their home cages overnight or for 21 d, followed by additional extinction training and a test of cocaine-seeking behavior (nonreinforced active lever responding). BLA/DH disconnection following re-exposure to the cocaine-paired context, but not the unpaired context, impaired subsequent drug context-induced cocaine-seeking behavior relative to vehicle or ipsilateral ANI + B/M treatment. Prolonged home cage stay elicited a time-dependent increase, or incubation, of drug-context-induced cocaine-seeking behavior, and BLA/DH disconnection inhibited this incubation effect despite some recovery of cocaine-seeking behavior. Thus, the BLA and DH interact to regulate the reconsolidation of cocaine-related associative memories, thereby facilitating the ability of drug-paired contexts to trigger cocaine-seeking behavior and contributing to the incubation of cocaine-seeking behavior.

Authors+Show Affiliations

Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599-3270, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22005750

Citation

Wells, Audrey M., et al. "Interaction Between the Basolateral Amygdala and Dorsal Hippocampus Is Critical for Cocaine Memory Reconsolidation and Subsequent Drug Context-induced Cocaine-seeking Behavior in Rats." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 18, no. 11, 2011, pp. 693-702.
Wells AM, Lasseter HC, Xie X, et al. Interaction between the basolateral amygdala and dorsal hippocampus is critical for cocaine memory reconsolidation and subsequent drug context-induced cocaine-seeking behavior in rats. Learn Mem. 2011;18(11):693-702.
Wells, A. M., Lasseter, H. C., Xie, X., Cowhey, K. E., Reittinger, A. M., & Fuchs, R. A. (2011). Interaction between the basolateral amygdala and dorsal hippocampus is critical for cocaine memory reconsolidation and subsequent drug context-induced cocaine-seeking behavior in rats. Learning & Memory (Cold Spring Harbor, N.Y.), 18(11), 693-702. https://doi.org/10.1101/lm.2273111
Wells AM, et al. Interaction Between the Basolateral Amygdala and Dorsal Hippocampus Is Critical for Cocaine Memory Reconsolidation and Subsequent Drug Context-induced Cocaine-seeking Behavior in Rats. Learn Mem. 2011;18(11):693-702. PubMed PMID: 22005750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between the basolateral amygdala and dorsal hippocampus is critical for cocaine memory reconsolidation and subsequent drug context-induced cocaine-seeking behavior in rats. AU - Wells,Audrey M, AU - Lasseter,Heather C, AU - Xie,Xiaohu, AU - Cowhey,Kate E, AU - Reittinger,Andrew M, AU - Fuchs,Rita A, Y1 - 2011/10/17/ PY - 2011/10/19/entrez PY - 2011/10/19/pubmed PY - 2012/3/1/medline SP - 693 EP - 702 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 18 IS - 11 N2 - Contextual stimulus control over instrumental drug-seeking behavior relies on the reconsolidation of context-response-drug associative memories into long-term memory storage following retrieval-induced destabilization. According to previous studies, the basolateral amygdala (BLA) and dorsal hippocampus (DH) regulate cocaine-related memory reconsolidation; however, it is not known whether these brain regions interact or independently control this phenomenon. To investigate this question, rats were trained to lever press for cocaine reinforcement in a distinct environmental context followed by extinction training in a different context. Rats were then briefly re-exposed to the cocaine-paired context to destabilize cocaine-related memories, or they were exposed to an unpaired context. Immediately thereafter, the rats received unilateral microinfusions of anisomycin (ANI) into the BLA plus baclofen/muscimol (B/M) into the contralateral (BLA/DH disconnection) or ipsilateral DH, or they received contralateral or ipsilateral microinfusions of vehicle. They then remained in their home cages overnight or for 21 d, followed by additional extinction training and a test of cocaine-seeking behavior (nonreinforced active lever responding). BLA/DH disconnection following re-exposure to the cocaine-paired context, but not the unpaired context, impaired subsequent drug context-induced cocaine-seeking behavior relative to vehicle or ipsilateral ANI + B/M treatment. Prolonged home cage stay elicited a time-dependent increase, or incubation, of drug-context-induced cocaine-seeking behavior, and BLA/DH disconnection inhibited this incubation effect despite some recovery of cocaine-seeking behavior. Thus, the BLA and DH interact to regulate the reconsolidation of cocaine-related associative memories, thereby facilitating the ability of drug-paired contexts to trigger cocaine-seeking behavior and contributing to the incubation of cocaine-seeking behavior. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/22005750/Interaction_between_the_basolateral_amygdala_and_dorsal_hippocampus_is_critical_for_cocaine_memory_reconsolidation_and_subsequent_drug_context_induced_cocaine_seeking_behavior_in_rats_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22005750/ DB - PRIME DP - Unbound Medicine ER -