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Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants.
J Pediatr Gastroenterol Nutr 2012; 54(3):353-63JP

Abstract

OBJECTIVES

Long-chain polyunsaturated fatty acid (LC-PUFA) enrichment of preterm infant formulas is recommended to meet high demands. Dietary LC-PUFA may inhibit endogenous LC-PUFA synthesis, thus limiting their benefit. We investigated effects of different docosahexaenoic acid (DHA) intakes on plasma and erythrocyte fatty acids and endogenous LC-PUFA synthesis in preterm infants.

METHODS

Forty-two preterm infants (birth weight 1000-2200 g) were randomized double-blind to preterm formulas with γ-linolenic acid (0.4%) and arachidonic acid (AA, 0.1%) but different DHA contents (A: 0.04%, B: 0.33%, C: 0.52%); 24 received human milk (HM: 0.51% AA, 0.38% DHA, nonrandomized). Blood was sampled on study days 0, 14, and 28. Uniformly C-labeled linoleic acid (2 mg/kg) and α-linolenic acid (1 mg/kg) were applied orally on day 26 and blood samples collected 48 hours later.

RESULTS

On day 28, group A had the lowest and group C the highest plasma phospholipid concentrations of eicosapentaenoic acid and DHA. Erythrocyte phospholipid DHA was lowest in group A, but comparable in groups B, C, and HM. Plasma and erythrocyte AA were lower in formula groups than in HM. DHA intake had no effect on DHA synthesis. LC-PUFA synthesis was lower in HM infants.

CONCLUSIONS

DHA supply dose dependently increased plasma DHA. Formula DHA levels of 0.33% matched plasma DHA status of infants fed HM. LC-PUFA synthesis was lower in infants fed HM than formulas with different DHA and low AA contents. With the LC-PUFA supplementation used, DHA in formulas did not inhibit AA or DHA synthesis.

Authors+Show Affiliations

University of Munich Medical Centre, Zentralklinikum Augsburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22008957

Citation

Sauerwald, Ulrike C., et al. "Effect of Different Levels of Docosahexaenoic Acid Supply On Fatty Acid Status and Linoleic and Α-linolenic Acid Conversion in Preterm Infants." Journal of Pediatric Gastroenterology and Nutrition, vol. 54, no. 3, 2012, pp. 353-63.
Sauerwald UC, Fink MM, Demmelmair H, et al. Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. J Pediatr Gastroenterol Nutr. 2012;54(3):353-63.
Sauerwald, U. C., Fink, M. M., Demmelmair, H., Schoenaich, P. V., Rauh-Pfeiffer, A. A., & Koletzko, B. (2012). Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. Journal of Pediatric Gastroenterology and Nutrition, 54(3), pp. 353-63. doi:10.1097/MPG.0b013e31823c3bfd.
Sauerwald UC, et al. Effect of Different Levels of Docosahexaenoic Acid Supply On Fatty Acid Status and Linoleic and Α-linolenic Acid Conversion in Preterm Infants. J Pediatr Gastroenterol Nutr. 2012;54(3):353-63. PubMed PMID: 22008957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. AU - Sauerwald,Ulrike C, AU - Fink,Maria M, AU - Demmelmair,Hans, AU - Schoenaich,Patrick V, AU - Rauh-Pfeiffer,Astrid A M, AU - Koletzko,Berthold, PY - 2011/10/20/entrez PY - 2011/10/20/pubmed PY - 2012/9/6/medline SP - 353 EP - 63 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 54 IS - 3 N2 - OBJECTIVES: Long-chain polyunsaturated fatty acid (LC-PUFA) enrichment of preterm infant formulas is recommended to meet high demands. Dietary LC-PUFA may inhibit endogenous LC-PUFA synthesis, thus limiting their benefit. We investigated effects of different docosahexaenoic acid (DHA) intakes on plasma and erythrocyte fatty acids and endogenous LC-PUFA synthesis in preterm infants. METHODS: Forty-two preterm infants (birth weight 1000-2200 g) were randomized double-blind to preterm formulas with γ-linolenic acid (0.4%) and arachidonic acid (AA, 0.1%) but different DHA contents (A: 0.04%, B: 0.33%, C: 0.52%); 24 received human milk (HM: 0.51% AA, 0.38% DHA, nonrandomized). Blood was sampled on study days 0, 14, and 28. Uniformly C-labeled linoleic acid (2 mg/kg) and α-linolenic acid (1 mg/kg) were applied orally on day 26 and blood samples collected 48 hours later. RESULTS: On day 28, group A had the lowest and group C the highest plasma phospholipid concentrations of eicosapentaenoic acid and DHA. Erythrocyte phospholipid DHA was lowest in group A, but comparable in groups B, C, and HM. Plasma and erythrocyte AA were lower in formula groups than in HM. DHA intake had no effect on DHA synthesis. LC-PUFA synthesis was lower in HM infants. CONCLUSIONS: DHA supply dose dependently increased plasma DHA. Formula DHA levels of 0.33% matched plasma DHA status of infants fed HM. LC-PUFA synthesis was lower in infants fed HM than formulas with different DHA and low AA contents. With the LC-PUFA supplementation used, DHA in formulas did not inhibit AA or DHA synthesis. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/22008957/Effect_of_different_levels_of_docosahexaenoic_acid_supply_on_fatty_acid_status_and_linoleic_and_α_linolenic_acid_conversion_in_preterm_infants_ L2 - http://Insights.ovid.com/pubmed?pmid=22008957 DB - PRIME DP - Unbound Medicine ER -