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Role of delayed type hypersensitivity responses in protection during chronic Plasmodium berghei infection as evidenced by homing of radiolabelled bone marrow cells and contact sensitivity.
Jpn J Exp Med. 1990 Apr; 60(2):45-50.JJ

Abstract

A comparative study of specific and non-specific immunosuppression has been carried out in acute and chronic Plasmodium berghei infected mice in an in vivo system. In our previous studies, immunosuppression during acute P. berghei infection was attributed to T lymphocytes when we studied modulation of blastogenic response of lymphocytes in an in vitro system. In the present study, delayed type hypersensitivity (DTH) was evident from the homing of radiolabelled bone marrow cells into the delayed lesions of antigen challenged foot pads during chronic infection. This response was suppressed during acute infection especially in early stages. A greater concentration of bone marrow cells in the liver and spleen occurred during chronic infection in comparison with acute infection. When radiolabelled bone marrow cells from infected mice were injected into the normal mice previously given malaria antigen in foot pads, no significant change in homing pattern in liver, spleen or foot pads was observed. Contact sensitivity to picryl chloride was suppressed during acute infection, but was intact during chronic infection. Since these responses are mediated by T lymphocytes, significance of these responses is discussed.

Authors+Show Affiliations

Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2200902

Citation

Wangoo, A, et al. "Role of Delayed Type Hypersensitivity Responses in Protection During Chronic Plasmodium Berghei Infection as Evidenced By Homing of Radiolabelled Bone Marrow Cells and Contact Sensitivity." The Japanese Journal of Experimental Medicine, vol. 60, no. 2, 1990, pp. 45-50.
Wangoo A, Ganguly NK, Mahajan RC. Role of delayed type hypersensitivity responses in protection during chronic Plasmodium berghei infection as evidenced by homing of radiolabelled bone marrow cells and contact sensitivity. Jpn J Exp Med. 1990;60(2):45-50.
Wangoo, A., Ganguly, N. K., & Mahajan, R. C. (1990). Role of delayed type hypersensitivity responses in protection during chronic Plasmodium berghei infection as evidenced by homing of radiolabelled bone marrow cells and contact sensitivity. The Japanese Journal of Experimental Medicine, 60(2), 45-50.
Wangoo A, Ganguly NK, Mahajan RC. Role of Delayed Type Hypersensitivity Responses in Protection During Chronic Plasmodium Berghei Infection as Evidenced By Homing of Radiolabelled Bone Marrow Cells and Contact Sensitivity. Jpn J Exp Med. 1990;60(2):45-50. PubMed PMID: 2200902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of delayed type hypersensitivity responses in protection during chronic Plasmodium berghei infection as evidenced by homing of radiolabelled bone marrow cells and contact sensitivity. AU - Wangoo,A, AU - Ganguly,N K, AU - Mahajan,R C, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 45 EP - 50 JF - The Japanese journal of experimental medicine JO - Jpn J Exp Med VL - 60 IS - 2 N2 - A comparative study of specific and non-specific immunosuppression has been carried out in acute and chronic Plasmodium berghei infected mice in an in vivo system. In our previous studies, immunosuppression during acute P. berghei infection was attributed to T lymphocytes when we studied modulation of blastogenic response of lymphocytes in an in vitro system. In the present study, delayed type hypersensitivity (DTH) was evident from the homing of radiolabelled bone marrow cells into the delayed lesions of antigen challenged foot pads during chronic infection. This response was suppressed during acute infection especially in early stages. A greater concentration of bone marrow cells in the liver and spleen occurred during chronic infection in comparison with acute infection. When radiolabelled bone marrow cells from infected mice were injected into the normal mice previously given malaria antigen in foot pads, no significant change in homing pattern in liver, spleen or foot pads was observed. Contact sensitivity to picryl chloride was suppressed during acute infection, but was intact during chronic infection. Since these responses are mediated by T lymphocytes, significance of these responses is discussed. SN - 0021-5031 UR - https://www.unboundmedicine.com/medline/citation/2200902/Role_of_delayed_type_hypersensitivity_responses_in_protection_during_chronic_Plasmodium_berghei_infection_as_evidenced_by_homing_of_radiolabelled_bone_marrow_cells_and_contact_sensitivity_ L2 - https://medlineplus.gov/malaria.html DB - PRIME DP - Unbound Medicine ER -