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Comparative in vitro antimicrobial activity of vancomycin, teicoplanin, daptomycin and ceftobiprole in four different peritoneal dialysis fluids.
Eur J Clin Microbiol Infect Dis. 2012 Jul; 31(7):1327-34.EJ

Abstract

Peritoneal dialysis used in the treatment of patients with end-stage renal failure is often complicated by peritonitis. Staphylococcus aureus peritonitis is severe, particularly if caused by a methicillin-resistant strain (MRSA). Intraperitoneal administration of drugs for treatment of peritonitis is preferable to intravenous or oral routes because of the resulting higher local antibiotic concentrations. However, peritoneal dialysis fluids (PDFs) have a bacteriostatic effect, which may compromise the efficacy of antibiotics. The bactericidal efficacy of vancomycin, teicoplanin, daptomycin and ceftobiprole was studied in the PDFs Dianeal PD4® (glucose 1.36%), Physioneal 40® (glucose 1.36%), Extraneal® (7.5% icodextrin), and Nutrineal PD4® (1.1% amino acid) using time-kill curves. To simulate in vivo conditions, human serum albumin was added at a final concentration of 2 g/l. All four PDFs had a bacteriostatic effect on the growth of the MRSA test isolate. All antibiotics showed less activity in PDFs compared to control broth. Vancomycin and teicoplanin achieved the greatest reduction in bacterial numbers in the amino-acid containing PDF Nutrineal PD4®. Daptomycin showed its highest activity in Extraneal® and better overall efficacy than the other tested antibiotics. Ceftobiprole showed no killing activities in any of the four PDFs. Based on these in vitro data we conclude that the choice of PDFs for intraperitoneal administration is not trivial and could be crucial for therapy outcome.

Authors+Show Affiliations

Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22009289

Citation

Tobudic, S, et al. "Comparative in Vitro Antimicrobial Activity of Vancomycin, Teicoplanin, Daptomycin and Ceftobiprole in Four Different Peritoneal Dialysis Fluids." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, vol. 31, no. 7, 2012, pp. 1327-34.
Tobudic S, Poeppl W, Kratzer C, et al. Comparative in vitro antimicrobial activity of vancomycin, teicoplanin, daptomycin and ceftobiprole in four different peritoneal dialysis fluids. Eur J Clin Microbiol Infect Dis. 2012;31(7):1327-34.
Tobudic, S., Poeppl, W., Kratzer, C., Vychytil, A., & Burgmann, H. (2012). Comparative in vitro antimicrobial activity of vancomycin, teicoplanin, daptomycin and ceftobiprole in four different peritoneal dialysis fluids. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 31(7), 1327-34. https://doi.org/10.1007/s10096-011-1446-0
Tobudic S, et al. Comparative in Vitro Antimicrobial Activity of Vancomycin, Teicoplanin, Daptomycin and Ceftobiprole in Four Different Peritoneal Dialysis Fluids. Eur J Clin Microbiol Infect Dis. 2012;31(7):1327-34. PubMed PMID: 22009289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative in vitro antimicrobial activity of vancomycin, teicoplanin, daptomycin and ceftobiprole in four different peritoneal dialysis fluids. AU - Tobudic,S, AU - Poeppl,W, AU - Kratzer,C, AU - Vychytil,A, AU - Burgmann,H, Y1 - 2011/10/19/ PY - 2011/05/11/received PY - 2011/10/01/accepted PY - 2011/10/20/entrez PY - 2011/10/20/pubmed PY - 2012/8/31/medline SP - 1327 EP - 34 JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur J Clin Microbiol Infect Dis VL - 31 IS - 7 N2 - Peritoneal dialysis used in the treatment of patients with end-stage renal failure is often complicated by peritonitis. Staphylococcus aureus peritonitis is severe, particularly if caused by a methicillin-resistant strain (MRSA). Intraperitoneal administration of drugs for treatment of peritonitis is preferable to intravenous or oral routes because of the resulting higher local antibiotic concentrations. However, peritoneal dialysis fluids (PDFs) have a bacteriostatic effect, which may compromise the efficacy of antibiotics. The bactericidal efficacy of vancomycin, teicoplanin, daptomycin and ceftobiprole was studied in the PDFs Dianeal PD4® (glucose 1.36%), Physioneal 40® (glucose 1.36%), Extraneal® (7.5% icodextrin), and Nutrineal PD4® (1.1% amino acid) using time-kill curves. To simulate in vivo conditions, human serum albumin was added at a final concentration of 2 g/l. All four PDFs had a bacteriostatic effect on the growth of the MRSA test isolate. All antibiotics showed less activity in PDFs compared to control broth. Vancomycin and teicoplanin achieved the greatest reduction in bacterial numbers in the amino-acid containing PDF Nutrineal PD4®. Daptomycin showed its highest activity in Extraneal® and better overall efficacy than the other tested antibiotics. Ceftobiprole showed no killing activities in any of the four PDFs. Based on these in vitro data we conclude that the choice of PDFs for intraperitoneal administration is not trivial and could be crucial for therapy outcome. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/22009289/Comparative_in_vitro_antimicrobial_activity_of_vancomycin_teicoplanin_daptomycin_and_ceftobiprole_in_four_different_peritoneal_dialysis_fluids_ L2 - https://dx.doi.org/10.1007/s10096-011-1446-0 DB - PRIME DP - Unbound Medicine ER -