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Symptoms of depression and anxiety over time in chronic hemodialysis patients.
J Nephrol. 2012 Sep-Oct; 25(5):689-98.JN

Abstract

BACKGROUND

Little is known about the course of the symptoms of depression/anxiety and the factors predictive of such courses in hemodialysis (HD) patients. This study aimed at evaluating the possible changes of Beck Depression Inventory (BDI) and Hamilton Anxiety Rating Scale (HARS) over time, and factors associated with such changes in HD patients.

METHODS

We screened 110 patients for study participation. Of these, 30 were excluded because of dialytic vintage <6 months, alcohol/substance abuse, inability to answer to the questionnaires, diagnosis of psychotic or neurological disorders or recent stressful life events. Eighty patients were included in the study and BDI, HARS, Charlson Comorbidity Index, SF-36 Vitality Subscale, Mini-Mental State Examination (MMSE), routine laboratory parameters, C-reactive protein (CRP) and interleukin-6 were measured at baseline. The 18-month course of BDI and HARS was measured in patients with baseline BDI ≤14.

RESULTS

At baseline, 42 patients had BDI >14 and 38 patients ≤14. In patients with BDI ≤14, the BDI decreased/remained stable in 19 and increased in 19. Patients with increased BDI had lower baseline MMSE (22.6 ± 2.6 vs. 25.9 ± 2.7, p=0.004) and higher baseline serum CRP (6.07 ± 4.2 vs. 1.64 ± 1.59, p=0.003). At multivariate analysis the relationship between BDI changes and MMSE and serum CRP was statistically significant. In 25 patients, the HARS decreased/remained stable, while in 13 it increased. Characteristics of the 2 groups of patients did not differ significantly.

CONCLUSIONS

In a meaningful proportion of HD patients, symptoms of depression worsen over time, and CRP and MMSE are independent predictors of such change.

Authors+Show Affiliations

Dialysis Service, Department of Surgery, Catholic University of the Sacred Heart, Rome, Italy. maubosso@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22009936

Citation

Bossola, Maurizio, et al. "Symptoms of Depression and Anxiety Over Time in Chronic Hemodialysis Patients." Journal of Nephrology, vol. 25, no. 5, 2012, pp. 689-98.
Bossola M, Ciciarelli C, Di Stasio E, et al. Symptoms of depression and anxiety over time in chronic hemodialysis patients. J Nephrol. 2012;25(5):689-98.
Bossola, M., Ciciarelli, C., Di Stasio, E., Conte, G. L., Antocicco, M., Rosa, F., & Tazza, L. (2012). Symptoms of depression and anxiety over time in chronic hemodialysis patients. Journal of Nephrology, 25(5), 689-98. https://doi.org/10.5301/jn.5000042
Bossola M, et al. Symptoms of Depression and Anxiety Over Time in Chronic Hemodialysis Patients. J Nephrol. 2012 Sep-Oct;25(5):689-98. PubMed PMID: 22009936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Symptoms of depression and anxiety over time in chronic hemodialysis patients. AU - Bossola,Maurizio, AU - Ciciarelli,Claudia, AU - Di Stasio,Enrico, AU - Conte,Gian Luigi, AU - Antocicco,Manuela, AU - Rosa,Fausto, AU - Tazza,Luigi, PY - 2011/09/05/accepted PY - 2011/10/20/entrez PY - 2011/10/20/pubmed PY - 2013/2/23/medline SP - 689 EP - 98 JF - Journal of nephrology JO - J Nephrol VL - 25 IS - 5 N2 - BACKGROUND: Little is known about the course of the symptoms of depression/anxiety and the factors predictive of such courses in hemodialysis (HD) patients. This study aimed at evaluating the possible changes of Beck Depression Inventory (BDI) and Hamilton Anxiety Rating Scale (HARS) over time, and factors associated with such changes in HD patients. METHODS: We screened 110 patients for study participation. Of these, 30 were excluded because of dialytic vintage <6 months, alcohol/substance abuse, inability to answer to the questionnaires, diagnosis of psychotic or neurological disorders or recent stressful life events. Eighty patients were included in the study and BDI, HARS, Charlson Comorbidity Index, SF-36 Vitality Subscale, Mini-Mental State Examination (MMSE), routine laboratory parameters, C-reactive protein (CRP) and interleukin-6 were measured at baseline. The 18-month course of BDI and HARS was measured in patients with baseline BDI ≤14. RESULTS: At baseline, 42 patients had BDI >14 and 38 patients ≤14. In patients with BDI ≤14, the BDI decreased/remained stable in 19 and increased in 19. Patients with increased BDI had lower baseline MMSE (22.6 ± 2.6 vs. 25.9 ± 2.7, p=0.004) and higher baseline serum CRP (6.07 ± 4.2 vs. 1.64 ± 1.59, p=0.003). At multivariate analysis the relationship between BDI changes and MMSE and serum CRP was statistically significant. In 25 patients, the HARS decreased/remained stable, while in 13 it increased. Characteristics of the 2 groups of patients did not differ significantly. CONCLUSIONS: In a meaningful proportion of HD patients, symptoms of depression worsen over time, and CRP and MMSE are independent predictors of such change. SN - 1724-6059 UR - https://www.unboundmedicine.com/medline/citation/22009936/Symptoms_of_depression_and_anxiety_over_time_in_chronic_hemodialysis_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=22009936.ui DB - PRIME DP - Unbound Medicine ER -