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Near-full genome characterization of unclassified hepatitis C virus strains relating to genotypes 1 and 4.
J Med Virol. 2011 Dec; 83(12):2119-27.JM

Abstract

Near-full genome sequences are presented in this report for the first time of unclassified HCV strains amplified using RT-PCR from plasma of patients living in Cyprus. One strain appears to be a unique genotype-1-like isolate, displaying closer phylogenetic relationship to genotype 1 strains than other genotypes. Two isolates representing an unclassified variant of genotype 4 were also amplified, cases of which have been found elsewhere in the world in patients of central African origin and could now be assigned provisionally as new subtype 4v. The near-full genome nucleotide sequences of unclassified HCV isolates provide reference sequences of variants unknown previously, and contribute to the publicly available HCV sequence data to be used for diagnosis or research.

Authors+Show Affiliations

Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22012719

Citation

Demetriou, Victoria L., and Leondios G. Kostrikis. "Near-full Genome Characterization of Unclassified Hepatitis C Virus Strains Relating to Genotypes 1 and 4." Journal of Medical Virology, vol. 83, no. 12, 2011, pp. 2119-27.
Demetriou VL, Kostrikis LG. Near-full genome characterization of unclassified hepatitis C virus strains relating to genotypes 1 and 4. J Med Virol. 2011;83(12):2119-27.
Demetriou, V. L., & Kostrikis, L. G. (2011). Near-full genome characterization of unclassified hepatitis C virus strains relating to genotypes 1 and 4. Journal of Medical Virology, 83(12), 2119-27. https://doi.org/10.1002/jmv.22237
Demetriou VL, Kostrikis LG. Near-full Genome Characterization of Unclassified Hepatitis C Virus Strains Relating to Genotypes 1 and 4. J Med Virol. 2011;83(12):2119-27. PubMed PMID: 22012719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Near-full genome characterization of unclassified hepatitis C virus strains relating to genotypes 1 and 4. AU - Demetriou,Victoria L, AU - Kostrikis,Leondios G, PY - 2011/10/21/entrez PY - 2011/10/21/pubmed PY - 2012/2/9/medline SP - 2119 EP - 27 JF - Journal of medical virology JO - J Med Virol VL - 83 IS - 12 N2 - Near-full genome sequences are presented in this report for the first time of unclassified HCV strains amplified using RT-PCR from plasma of patients living in Cyprus. One strain appears to be a unique genotype-1-like isolate, displaying closer phylogenetic relationship to genotype 1 strains than other genotypes. Two isolates representing an unclassified variant of genotype 4 were also amplified, cases of which have been found elsewhere in the world in patients of central African origin and could now be assigned provisionally as new subtype 4v. The near-full genome nucleotide sequences of unclassified HCV isolates provide reference sequences of variants unknown previously, and contribute to the publicly available HCV sequence data to be used for diagnosis or research. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/22012719/Near_full_genome_characterization_of_unclassified_hepatitis_C_virus_strains_relating_to_genotypes_1_and_4_ L2 - https://doi.org/10.1002/jmv.22237 DB - PRIME DP - Unbound Medicine ER -