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Intrathecal antibody production in two cases of yellow fever vaccine associated neurotropic disease in Argentina.
J Med Virol. 2011 Dec; 83(12):2208-12.JM

Abstract

During the period 2007-2008 several epizootics of Yellow fever with dead of monkeys occurred in southeastern Brasil, Paraguay, and northeastern Argentina. In 2008 after a Yellow fever outbreak an exhaustive prevention campaign took place in Argentina using 17D live attenuated Yellow fever vaccine. This vaccine is considered one of the safest live virus vaccines, although serious adverse reactions may occur after vaccination, and vaccine-associated neurotropic disease are reported rarely. The aim of this study was to confirm two serious adverse events associated to Yellow fever vaccine in Argentina, and to describe the analysis performed to assess the origin of specific IgM against Yellow fever virus (YFV) in cerebrospinal fluid (CSF). Both cases coincided with the Yellow fever vaccine-associated neurotropic disease case definition, being clinical diagnosis longitudinal myelitis (case 1) and meningoencephalitis (case 2). Specific YFV antibodies were detected in CSF and serum samples in both cases by IgM antibody-capture ELISA. No other cause of neurological disease was identified. In order to obtain a conclusive diagnosis of central nervous system (CNS) infection the IgM antibody index (AI(IgM)) was calculated. High AI(IgM) values were found in both cases indicating intrathecal production of antibodies and, therefore, CNS post-vaccinal YFV infection could be definitively associated to YFV vaccination.

Authors+Show Affiliations

National Institute for Infectious Disease, National Administration of Laboratories, Buenos Aires, Argentina. piresfanny@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22012730

Citation

Pires-Marczeski, Fanny Clara, et al. "Intrathecal Antibody Production in Two Cases of Yellow Fever Vaccine Associated Neurotropic Disease in Argentina." Journal of Medical Virology, vol. 83, no. 12, 2011, pp. 2208-12.
Pires-Marczeski FC, Martinez VP, Nemirovsky C, et al. Intrathecal antibody production in two cases of yellow fever vaccine associated neurotropic disease in Argentina. J Med Virol. 2011;83(12):2208-12.
Pires-Marczeski, F. C., Martinez, V. P., Nemirovsky, C., & Padula, P. J. (2011). Intrathecal antibody production in two cases of yellow fever vaccine associated neurotropic disease in Argentina. Journal of Medical Virology, 83(12), 2208-12. https://doi.org/10.1002/jmv.22236
Pires-Marczeski FC, et al. Intrathecal Antibody Production in Two Cases of Yellow Fever Vaccine Associated Neurotropic Disease in Argentina. J Med Virol. 2011;83(12):2208-12. PubMed PMID: 22012730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrathecal antibody production in two cases of yellow fever vaccine associated neurotropic disease in Argentina. AU - Pires-Marczeski,Fanny Clara, AU - Martinez,Valeria Paula, AU - Nemirovsky,Corina, AU - Padula,Paula Julieta, PY - 2011/10/21/entrez PY - 2011/10/21/pubmed PY - 2012/2/9/medline SP - 2208 EP - 12 JF - Journal of medical virology JO - J Med Virol VL - 83 IS - 12 N2 - During the period 2007-2008 several epizootics of Yellow fever with dead of monkeys occurred in southeastern Brasil, Paraguay, and northeastern Argentina. In 2008 after a Yellow fever outbreak an exhaustive prevention campaign took place in Argentina using 17D live attenuated Yellow fever vaccine. This vaccine is considered one of the safest live virus vaccines, although serious adverse reactions may occur after vaccination, and vaccine-associated neurotropic disease are reported rarely. The aim of this study was to confirm two serious adverse events associated to Yellow fever vaccine in Argentina, and to describe the analysis performed to assess the origin of specific IgM against Yellow fever virus (YFV) in cerebrospinal fluid (CSF). Both cases coincided with the Yellow fever vaccine-associated neurotropic disease case definition, being clinical diagnosis longitudinal myelitis (case 1) and meningoencephalitis (case 2). Specific YFV antibodies were detected in CSF and serum samples in both cases by IgM antibody-capture ELISA. No other cause of neurological disease was identified. In order to obtain a conclusive diagnosis of central nervous system (CNS) infection the IgM antibody index (AI(IgM)) was calculated. High AI(IgM) values were found in both cases indicating intrathecal production of antibodies and, therefore, CNS post-vaccinal YFV infection could be definitively associated to YFV vaccination. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/22012730/Intrathecal_antibody_production_in_two_cases_of_yellow_fever_vaccine_associated_neurotropic_disease_in_Argentina_ L2 - https://doi.org/10.1002/jmv.22236 DB - PRIME DP - Unbound Medicine ER -