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Protective effect of recombinant human erythropoietin against cisplatin-induced oxidative stress and nephrotoxicity in rat kidney.
Int J Toxicol. 2011 Oct; 30(5):510-7.IJ

Abstract

Cisplatin (Cisp) is one of the most widely used chemotherapeutic agents for the treatment of several human malignancies. The efficacy of Cisp is dose dependent and at higher doses serious kidney injury may occur. Recombinant human erythropoietin (rhEPO) has recently been shown to exert an important cytoprotective effect in experimental brain injury and ischemic acute renal failure. The aim of the present study was to explore whether rhEPO administration is protective against Cisp-induced oxidative damage and renal injury. Our results showed that Cisp induced a marked oxidative stress and renal failure. Administration of rhEPO (pre-, co- or postadministration with regard to Cisp) decreased oxidative damage induced by Cisp. Recombinant human EPO reduced malondialdehyde and protein carbonyl levels. Recombinant human EPO also prevented glutathione depletion and ameliorated the increased catalase activity induced by Cisp treatment. Furthermore, rhEPO restored creatinine and blood urea nitrogen levels increased by Cisp. We concluded that rhEPO administration especially in pretreatment condition protected rats against Cisp-induced renal oxidative stress and nephrotoxicity.

Authors+Show Affiliations

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22013135

Citation

Rjiba-Touati, Karima, et al. "Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-induced Oxidative Stress and Nephrotoxicity in Rat Kidney." International Journal of Toxicology, vol. 30, no. 5, 2011, pp. 510-7.
Rjiba-Touati K, Boussema IA, Belarbia A, et al. Protective effect of recombinant human erythropoietin against cisplatin-induced oxidative stress and nephrotoxicity in rat kidney. Int J Toxicol. 2011;30(5):510-7.
Rjiba-Touati, K., Boussema, I. A., Belarbia, A., Achour, A., & Bacha, H. (2011). Protective effect of recombinant human erythropoietin against cisplatin-induced oxidative stress and nephrotoxicity in rat kidney. International Journal of Toxicology, 30(5), 510-7. https://doi.org/10.1177/1091581810411931
Rjiba-Touati K, et al. Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-induced Oxidative Stress and Nephrotoxicity in Rat Kidney. Int J Toxicol. 2011;30(5):510-7. PubMed PMID: 22013135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of recombinant human erythropoietin against cisplatin-induced oxidative stress and nephrotoxicity in rat kidney. AU - Rjiba-Touati,Karima, AU - Boussema,Imen Ayed, AU - Belarbia,Anis, AU - Achour,Abdelatif, AU - Bacha,Hassen, PY - 2011/10/21/entrez PY - 2011/10/21/pubmed PY - 2012/2/14/medline SP - 510 EP - 7 JF - International journal of toxicology JO - Int J Toxicol VL - 30 IS - 5 N2 - Cisplatin (Cisp) is one of the most widely used chemotherapeutic agents for the treatment of several human malignancies. The efficacy of Cisp is dose dependent and at higher doses serious kidney injury may occur. Recombinant human erythropoietin (rhEPO) has recently been shown to exert an important cytoprotective effect in experimental brain injury and ischemic acute renal failure. The aim of the present study was to explore whether rhEPO administration is protective against Cisp-induced oxidative damage and renal injury. Our results showed that Cisp induced a marked oxidative stress and renal failure. Administration of rhEPO (pre-, co- or postadministration with regard to Cisp) decreased oxidative damage induced by Cisp. Recombinant human EPO reduced malondialdehyde and protein carbonyl levels. Recombinant human EPO also prevented glutathione depletion and ameliorated the increased catalase activity induced by Cisp treatment. Furthermore, rhEPO restored creatinine and blood urea nitrogen levels increased by Cisp. We concluded that rhEPO administration especially in pretreatment condition protected rats against Cisp-induced renal oxidative stress and nephrotoxicity. SN - 1092-874X UR - https://www.unboundmedicine.com/medline/citation/22013135/Protective_effect_of_recombinant_human_erythropoietin_against_cisplatin_induced_oxidative_stress_and_nephrotoxicity_in_rat_kidney_ L2 - https://journals.sagepub.com/doi/10.1177/1091581810411931?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -