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Chronic daily cortical spreading depressions suppress spreading depression susceptibility.
Cephalalgia 2011; 31(16):1601-8C

Abstract

BACKGROUND

Migraine is a disabling chronic episodic disorder. Attack frequency progressively increases in some patients. Incremental cortical excitability has been implicated as a mechanism underlying progression. Cortical spreading depression (CSD) is the electrophysiological event underlying migraine aura, and a headache trigger. We hypothesized that CSD events during frequent migraine attacks condition the cortex to increase the susceptibility to further attacks.

METHODS

A single daily CSD was induced for 1 or 2 weeks in mouse frontal cortex; contralateral hemisphere served as sham control. At the end of CSD conditioning, occipital CSD susceptibility was determined by measuring the frequency of CSDs evoked by topical KCl application.

RESULTS

Sham hemispheres developed 8.4 ± 0.3 CSDs/hour, and did not significantly differ from naïve controls without prior cranial surgery (9.3 ± 0.4 CSDs/hour). After 2 but not 1 week of daily CSD conditioning, CSD frequency (4.9 ± 0.3 CSDs/hour) as well as the duration and propagation speed were reduced significantly in the conditioned hemispheres. Histopathological examination revealed marked reactive astrocytosis without neuronal injury throughout the conditioned cortex after 2 weeks, temporally associated with CSD susceptibility.

CONCLUSIONS

These data do not support the hypothesis that frequent migraine attacks predispose the brain to further attacks by enhancing tissue susceptibility to CSD.

Authors+Show Affiliations

Harvard Medical School, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22013142

Citation

Sukhotinsky, Inna, et al. "Chronic Daily Cortical Spreading Depressions Suppress Spreading Depression Susceptibility." Cephalalgia : an International Journal of Headache, vol. 31, no. 16, 2011, pp. 1601-8.
Sukhotinsky I, Dilekoz E, Wang Y, et al. Chronic daily cortical spreading depressions suppress spreading depression susceptibility. Cephalalgia. 2011;31(16):1601-8.
Sukhotinsky, I., Dilekoz, E., Wang, Y., Qin, T., Eikermann-Haerter, K., Waeber, C., & Ayata, C. (2011). Chronic daily cortical spreading depressions suppress spreading depression susceptibility. Cephalalgia : an International Journal of Headache, 31(16), pp. 1601-8. doi:10.1177/0333102411425865.
Sukhotinsky I, et al. Chronic Daily Cortical Spreading Depressions Suppress Spreading Depression Susceptibility. Cephalalgia. 2011;31(16):1601-8. PubMed PMID: 22013142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic daily cortical spreading depressions suppress spreading depression susceptibility. AU - Sukhotinsky,Inna, AU - Dilekoz,Ergin, AU - Wang,Yumei, AU - Qin,Tao, AU - Eikermann-Haerter,Katharina, AU - Waeber,Christian, AU - Ayata,Cenk, Y1 - 2011/10/19/ PY - 2011/10/21/entrez PY - 2011/10/21/pubmed PY - 2012/4/4/medline SP - 1601 EP - 8 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 31 IS - 16 N2 - BACKGROUND: Migraine is a disabling chronic episodic disorder. Attack frequency progressively increases in some patients. Incremental cortical excitability has been implicated as a mechanism underlying progression. Cortical spreading depression (CSD) is the electrophysiological event underlying migraine aura, and a headache trigger. We hypothesized that CSD events during frequent migraine attacks condition the cortex to increase the susceptibility to further attacks. METHODS: A single daily CSD was induced for 1 or 2 weeks in mouse frontal cortex; contralateral hemisphere served as sham control. At the end of CSD conditioning, occipital CSD susceptibility was determined by measuring the frequency of CSDs evoked by topical KCl application. RESULTS: Sham hemispheres developed 8.4 ± 0.3 CSDs/hour, and did not significantly differ from naïve controls without prior cranial surgery (9.3 ± 0.4 CSDs/hour). After 2 but not 1 week of daily CSD conditioning, CSD frequency (4.9 ± 0.3 CSDs/hour) as well as the duration and propagation speed were reduced significantly in the conditioned hemispheres. Histopathological examination revealed marked reactive astrocytosis without neuronal injury throughout the conditioned cortex after 2 weeks, temporally associated with CSD susceptibility. CONCLUSIONS: These data do not support the hypothesis that frequent migraine attacks predispose the brain to further attacks by enhancing tissue susceptibility to CSD. SN - 1468-2982 UR - https://www.unboundmedicine.com/medline/citation/22013142/Chronic_daily_cortical_spreading_depressions_suppress_spreading_depression_susceptibility_ L2 - http://journals.sagepub.com/doi/full/10.1177/0333102411425865?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -