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Paediatric multiple sclerosis: examining utility of the McDonald 2010 criteria.
Mult Scler 2012; 18(5):679-82MS

Abstract

The new McDonald 2010 criteria have been recommended in paediatric multiple sclerosis (PMS). We aimed to assess the utility of McDonald 2010 criteria in comparison with 2007 International Paediatric Multiple Sclerosis Study Group (IPMSSG)-recommended criteria for PMS diagnosis. Retrospective analysis of 38 PMS cases from three UK demyelination clinics was conducted. Dissemination in space (DIS) and time (DIT) for both McDonald and IPMSSG criteria were noted on initial and follow-up magnetic resonance imaging (MRI). At first MRI scan, IPMSSG DIS criteria were fulfilled in 68% of scans and McDonald DIS criteria in 84%. In total, 11/18 children given gadolinium contrast fulfilled both McDonald DIS and DIT criteria on initial scan. The 2010 McDonald criteria appear more sensitive than IPMSSG and may allow PMS diagnosis at first presentation of CIS in at least a half of cases.

Authors+Show Affiliations

Department of Paediatric Neurology, Birmingham Children's Hospital, Birmingham, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

22013145

Citation

Sedani, S, et al. "Paediatric Multiple Sclerosis: Examining Utility of the McDonald 2010 Criteria." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 18, no. 5, 2012, pp. 679-82.
Sedani S, Lim MJ, Hemingway C, et al. Paediatric multiple sclerosis: examining utility of the McDonald 2010 criteria. Mult Scler. 2012;18(5):679-82.
Sedani, S., Lim, M. J., Hemingway, C., Wassmer, E., & Absoud, M. (2012). Paediatric multiple sclerosis: examining utility of the McDonald 2010 criteria. Multiple Sclerosis (Houndmills, Basingstoke, England), 18(5), pp. 679-82. doi:10.1177/1352458511426815.
Sedani S, et al. Paediatric Multiple Sclerosis: Examining Utility of the McDonald 2010 Criteria. Mult Scler. 2012;18(5):679-82. PubMed PMID: 22013145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paediatric multiple sclerosis: examining utility of the McDonald 2010 criteria. AU - Sedani,S, AU - Lim,M J, AU - Hemingway,C, AU - Wassmer,E, AU - Absoud,M, Y1 - 2011/10/19/ PY - 2011/10/21/entrez PY - 2011/10/21/pubmed PY - 2012/8/28/medline SP - 679 EP - 82 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 18 IS - 5 N2 - The new McDonald 2010 criteria have been recommended in paediatric multiple sclerosis (PMS). We aimed to assess the utility of McDonald 2010 criteria in comparison with 2007 International Paediatric Multiple Sclerosis Study Group (IPMSSG)-recommended criteria for PMS diagnosis. Retrospective analysis of 38 PMS cases from three UK demyelination clinics was conducted. Dissemination in space (DIS) and time (DIT) for both McDonald and IPMSSG criteria were noted on initial and follow-up magnetic resonance imaging (MRI). At first MRI scan, IPMSSG DIS criteria were fulfilled in 68% of scans and McDonald DIS criteria in 84%. In total, 11/18 children given gadolinium contrast fulfilled both McDonald DIS and DIT criteria on initial scan. The 2010 McDonald criteria appear more sensitive than IPMSSG and may allow PMS diagnosis at first presentation of CIS in at least a half of cases. SN - 1477-0970 UR - https://www.unboundmedicine.com/medline/citation/22013145/Paediatric_multiple_sclerosis:_examining_utility_of_the_McDonald_2010_criteria_ L2 - http://journals.sagepub.com/doi/full/10.1177/1352458511426815?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -