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Which method of GFR estimation has the best prognostic value in patients treated with primary PCI: Cockcroft-Gault formula, MDRD, or CKD-EPI equation?--A 6-year follow-up.
Ren Fail. 2011; 33(10):983-9.RF

Abstract

BACKGROUND/AIMS

The aim of this study was to determine the correlation between renal function and 6-year mortality in patients with acute myocardial infarction (AMI), treated successfully with primary percutaneous coronary intervention (PCI), and to examine whether Cockcroft-Gault (C-G) formula or Modification of Diet in Renal Disease (MDRD) study equation or CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation is the best predictor of very late mortality.

METHODS

A prospective cohort study with 6-year follow-up of a homogenous group of 193 patients, with ST-segment elevation AMI treated with successful primary PCI. Glomerular filtration rate (GFR) estimated by C-G formula, MDRD, and CKD-EPI equation were analyzed.

RESULTS

The patients with chronic kidney disease (CKD) had a much lower cumulative survival rate than those without it (p < 0.05). A larger area under the receiver-operating characteristic curve for death with respect to GFR for C-G formula was observed. In the multivariate analysis, only GFR ≥ 55 mL/min according to C-G formula was independently associated with lower mortality.

CONCLUSION

CKD is associated with higher mortality after a successful primary PCI during a 6-year follow-up. C-G formula is better than MDRD and CKD-EPI equations at predicting mortality after AMI.

Authors+Show Affiliations

Department of Cardiology, Medical University, Bialystok, Poland. walkaz@poczta.fmNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22013931

Citation

Tomaszuk-Kazberuk, Anna, et al. "Which Method of GFR Estimation Has the Best Prognostic Value in Patients Treated With Primary PCI: Cockcroft-Gault Formula, MDRD, or CKD-EPI equation?--A 6-year Follow-up." Renal Failure, vol. 33, no. 10, 2011, pp. 983-9.
Tomaszuk-Kazberuk A, Kozuch M, Malyszko J, et al. Which method of GFR estimation has the best prognostic value in patients treated with primary PCI: Cockcroft-Gault formula, MDRD, or CKD-EPI equation?--A 6-year follow-up. Ren Fail. 2011;33(10):983-9.
Tomaszuk-Kazberuk, A., Kozuch, M., Malyszko, J., Bachorzewska-Gajewska, H., Dobrzycki, S., & Musial, W. J. (2011). Which method of GFR estimation has the best prognostic value in patients treated with primary PCI: Cockcroft-Gault formula, MDRD, or CKD-EPI equation?--A 6-year follow-up. Renal Failure, 33(10), 983-9. https://doi.org/10.3109/0886022X.2011.618922
Tomaszuk-Kazberuk A, et al. Which Method of GFR Estimation Has the Best Prognostic Value in Patients Treated With Primary PCI: Cockcroft-Gault Formula, MDRD, or CKD-EPI equation?--A 6-year Follow-up. Ren Fail. 2011;33(10):983-9. PubMed PMID: 22013931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Which method of GFR estimation has the best prognostic value in patients treated with primary PCI: Cockcroft-Gault formula, MDRD, or CKD-EPI equation?--A 6-year follow-up. AU - Tomaszuk-Kazberuk,Anna, AU - Kozuch,Marcin, AU - Malyszko,Jolanta, AU - Bachorzewska-Gajewska,Hanna, AU - Dobrzycki,Slawomir, AU - Musial,Wlodzimierz J, PY - 2011/10/22/entrez PY - 2011/10/22/pubmed PY - 2012/3/1/medline SP - 983 EP - 9 JF - Renal failure JO - Ren Fail VL - 33 IS - 10 N2 - BACKGROUND/AIMS: The aim of this study was to determine the correlation between renal function and 6-year mortality in patients with acute myocardial infarction (AMI), treated successfully with primary percutaneous coronary intervention (PCI), and to examine whether Cockcroft-Gault (C-G) formula or Modification of Diet in Renal Disease (MDRD) study equation or CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation is the best predictor of very late mortality. METHODS: A prospective cohort study with 6-year follow-up of a homogenous group of 193 patients, with ST-segment elevation AMI treated with successful primary PCI. Glomerular filtration rate (GFR) estimated by C-G formula, MDRD, and CKD-EPI equation were analyzed. RESULTS: The patients with chronic kidney disease (CKD) had a much lower cumulative survival rate than those without it (p < 0.05). A larger area under the receiver-operating characteristic curve for death with respect to GFR for C-G formula was observed. In the multivariate analysis, only GFR ≥ 55 mL/min according to C-G formula was independently associated with lower mortality. CONCLUSION: CKD is associated with higher mortality after a successful primary PCI during a 6-year follow-up. C-G formula is better than MDRD and CKD-EPI equations at predicting mortality after AMI. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/22013931/Which_method_of_GFR_estimation_has_the_best_prognostic_value_in_patients_treated_with_primary_PCI:_Cockcroft_Gault_formula_MDRD_or_CKD_EPI_equation__A_6_year_follow_up_ L2 - https://www.tandfonline.com/doi/full/10.3109/0886022X.2011.618922 DB - PRIME DP - Unbound Medicine ER -