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Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients.
Atherosclerosis. 2011 Dec; 219(2):925-30.A

Abstract

BACKGROUNDS

Osteoprotegerin (OPG) is known to regulate bone mineral metabolism and to be also associated with inflammation, cardiovascular disease (CVD) and mortality. Malnutrition-inflammation-atherosclerosis (MIA) syndrome is commonly found and closely linked to mortality in dialysis patients. The aim of this study was to investigate the associations between OPG and MIA syndrome in prevalent peritoneal dialysis (PD) patients.

METHODS

Prevalent PD patients for more than 6 months were prospectively followed up from March 2005 to May 2010. At baseline, OPG, hs-CRP, albumin, and %lean body mass (LBM) by creatinine kinetics were checked, and subjective global assessment (SGA) was performed. New-onset cardiovascular events were evaluated during the study period. Based on the median level of OPG, patients were classified as lower OPG (LO) group (n = 88) and higher OPG (HO) group (n = 88).

RESULTS

A total of 176 patients (age 52.0 ± 11.8 years, male 50.6%, duration of PD 105.3 ± 67.2 months) were recruited and followed. In HO group, age, hs-CRP level and Charlson's comorbidity indices were higher, whereas serum albumin level, %LBM and SGA score were significantly lower than LO group. OPG levels were positively correlated with inflammatory markers, whereas negatively correlated with nutritional status. Cardiovascular events occurred in 51 patients during the study period. Newly developed cardiovascular events were significantly common in HO group (n = 36, 40.9%) than LO group (n = 15, 17%, p = 0.002). Cox regression analysis revealed that higher OPG level (per 1-SD increase in OPG, HR: 1.44; 95% CI: 1.03-2.00; p = 0.034) was a significant risk factor for cardiovascular events even after adjustments for demographic and biochemical parameters.

CONCLUSION

OPG was significantly correlated with markers of systemic inflammation and malnutrition and was a significant predictor of CVD in PD patients. These findings suggest OPG might be a prognostic indicator of MIA syndrome in prevalent PD patients.

Authors+Show Affiliations

Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22015178

Citation

Koo, Hyang Mo, et al. "Elevated Osteoprotegerin Is Associated With Inflammation, Malnutrition and New Onset Cardiovascular Events in Peritoneal Dialysis Patients." Atherosclerosis, vol. 219, no. 2, 2011, pp. 925-30.
Koo HM, Do HM, Kim EJ, et al. Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients. Atherosclerosis. 2011;219(2):925-30.
Koo, H. M., Do, H. M., Kim, E. J., Lee, M. J., Shin, D. H., Kim, S. J., Oh, H. J., Yoo, D. E., Kim, J. K., Park, J. T., Han, S. H., Kang, S. W., Choi, K. H., & Yoo, T. H. (2011). Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients. Atherosclerosis, 219(2), 925-30. https://doi.org/10.1016/j.atherosclerosis.2011.09.025
Koo HM, et al. Elevated Osteoprotegerin Is Associated With Inflammation, Malnutrition and New Onset Cardiovascular Events in Peritoneal Dialysis Patients. Atherosclerosis. 2011;219(2):925-30. PubMed PMID: 22015178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated osteoprotegerin is associated with inflammation, malnutrition and new onset cardiovascular events in peritoneal dialysis patients. AU - Koo,Hyang Mo, AU - Do,Hwa Mi, AU - Kim,Eun Jin, AU - Lee,Mi Jung, AU - Shin,Dong Ho, AU - Kim,Seung Jun, AU - Oh,Hyung Jung, AU - Yoo,Dong Eun, AU - Kim,Jwa-Kyung, AU - Park,Jung Tak, AU - Han,Seung Hyeok, AU - Kang,Shin-Wook, AU - Choi,Kyu Hun, AU - Yoo,Tae-Hyun, Y1 - 2011/09/21/ PY - 2011/04/30/received PY - 2011/09/09/revised PY - 2011/09/12/accepted PY - 2011/10/22/entrez PY - 2011/10/22/pubmed PY - 2012/4/6/medline SP - 925 EP - 30 JF - Atherosclerosis JO - Atherosclerosis VL - 219 IS - 2 N2 - BACKGROUNDS: Osteoprotegerin (OPG) is known to regulate bone mineral metabolism and to be also associated with inflammation, cardiovascular disease (CVD) and mortality. Malnutrition-inflammation-atherosclerosis (MIA) syndrome is commonly found and closely linked to mortality in dialysis patients. The aim of this study was to investigate the associations between OPG and MIA syndrome in prevalent peritoneal dialysis (PD) patients. METHODS: Prevalent PD patients for more than 6 months were prospectively followed up from March 2005 to May 2010. At baseline, OPG, hs-CRP, albumin, and %lean body mass (LBM) by creatinine kinetics were checked, and subjective global assessment (SGA) was performed. New-onset cardiovascular events were evaluated during the study period. Based on the median level of OPG, patients were classified as lower OPG (LO) group (n = 88) and higher OPG (HO) group (n = 88). RESULTS: A total of 176 patients (age 52.0 ± 11.8 years, male 50.6%, duration of PD 105.3 ± 67.2 months) were recruited and followed. In HO group, age, hs-CRP level and Charlson's comorbidity indices were higher, whereas serum albumin level, %LBM and SGA score were significantly lower than LO group. OPG levels were positively correlated with inflammatory markers, whereas negatively correlated with nutritional status. Cardiovascular events occurred in 51 patients during the study period. Newly developed cardiovascular events were significantly common in HO group (n = 36, 40.9%) than LO group (n = 15, 17%, p = 0.002). Cox regression analysis revealed that higher OPG level (per 1-SD increase in OPG, HR: 1.44; 95% CI: 1.03-2.00; p = 0.034) was a significant risk factor for cardiovascular events even after adjustments for demographic and biochemical parameters. CONCLUSION: OPG was significantly correlated with markers of systemic inflammation and malnutrition and was a significant predictor of CVD in PD patients. These findings suggest OPG might be a prognostic indicator of MIA syndrome in prevalent PD patients. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/22015178/Elevated_osteoprotegerin_is_associated_with_inflammation_malnutrition_and_new_onset_cardiovascular_events_in_peritoneal_dialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(11)00931-2 DB - PRIME DP - Unbound Medicine ER -