Tags

Type your tag names separated by a space and hit enter

Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic-pituitary-adrenal axis activity across developmental periods.
Neuroscience. 2012 Mar 01; 204:17-30.N

Abstract

Growing evidence suggests that the endocannabinoid system is vital to ensuring normative maturation of the brain into adulthood. Endocannabinoid signaling contributes to guiding pro-neurogenic processes in early life and the development of neurotransmitter systems. Moreover, there is extensive evidence that recruitment of the endocannabinoid system is crucial in the regulation of neuroendocrine responses to stress via the hypothalamic-pituitary-adrenal (HPA) axis, and contributes to subsequent psychopathological consequences associated with emotionality and anxiety. These stress-induced physiological and behavioural sequelae are regulated by neural structures within the corticolimbic circuit, including the amygdala, hypothalamus, hippocampus, and prefrontal cortex. Based on evidence demonstrating endocannabinoid system involvement in both development and stress-induced changes in HPA axis function, it is reasonable to suggest that endocannabinoid signaling is an important mediator of interactions between stress responsivity and maturational stage. In this review, we discuss the ontogeny of the endocannabinoid system in the central nervous system, clinical and rodent models demonstrating short- and long-term effects of stress exposure, regulation of HPA axis responsivity by endocannabinoid signaling, as well as pharmacological and stress models indicating involvement of the endocannabinoid system in early post-natal and adolescent development on stress reactivity of the HPA, the corticolimbic system, and behaviour.

Authors+Show Affiliations

Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T1Z4.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22015924

Citation

Lee, T T-Y, and B B. Gorzalka. "Timing Is Everything: Evidence for a Role of Corticolimbic Endocannabinoids in Modulating Hypothalamic-pituitary-adrenal Axis Activity Across Developmental Periods." Neuroscience, vol. 204, 2012, pp. 17-30.
Lee TT, Gorzalka BB. Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic-pituitary-adrenal axis activity across developmental periods. Neuroscience. 2012;204:17-30.
Lee, T. T., & Gorzalka, B. B. (2012). Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic-pituitary-adrenal axis activity across developmental periods. Neuroscience, 204, 17-30. https://doi.org/10.1016/j.neuroscience.2011.10.006
Lee TT, Gorzalka BB. Timing Is Everything: Evidence for a Role of Corticolimbic Endocannabinoids in Modulating Hypothalamic-pituitary-adrenal Axis Activity Across Developmental Periods. Neuroscience. 2012 Mar 1;204:17-30. PubMed PMID: 22015924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Timing is everything: evidence for a role of corticolimbic endocannabinoids in modulating hypothalamic-pituitary-adrenal axis activity across developmental periods. AU - Lee,T T-Y, AU - Gorzalka,B B, Y1 - 2011/10/13/ PY - 2011/06/14/received PY - 2011/10/04/revised PY - 2011/10/05/accepted PY - 2011/10/22/entrez PY - 2011/10/22/pubmed PY - 2012/7/24/medline SP - 17 EP - 30 JF - Neuroscience JO - Neuroscience VL - 204 N2 - Growing evidence suggests that the endocannabinoid system is vital to ensuring normative maturation of the brain into adulthood. Endocannabinoid signaling contributes to guiding pro-neurogenic processes in early life and the development of neurotransmitter systems. Moreover, there is extensive evidence that recruitment of the endocannabinoid system is crucial in the regulation of neuroendocrine responses to stress via the hypothalamic-pituitary-adrenal (HPA) axis, and contributes to subsequent psychopathological consequences associated with emotionality and anxiety. These stress-induced physiological and behavioural sequelae are regulated by neural structures within the corticolimbic circuit, including the amygdala, hypothalamus, hippocampus, and prefrontal cortex. Based on evidence demonstrating endocannabinoid system involvement in both development and stress-induced changes in HPA axis function, it is reasonable to suggest that endocannabinoid signaling is an important mediator of interactions between stress responsivity and maturational stage. In this review, we discuss the ontogeny of the endocannabinoid system in the central nervous system, clinical and rodent models demonstrating short- and long-term effects of stress exposure, regulation of HPA axis responsivity by endocannabinoid signaling, as well as pharmacological and stress models indicating involvement of the endocannabinoid system in early post-natal and adolescent development on stress reactivity of the HPA, the corticolimbic system, and behaviour. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/22015924/Timing_is_everything:_evidence_for_a_role_of_corticolimbic_endocannabinoids_in_modulating_hypothalamic_pituitary_adrenal_axis_activity_across_developmental_periods_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(11)01180-8 DB - PRIME DP - Unbound Medicine ER -