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Abdominal obesity and late-onset asthma: cross-sectional and longitudinal results: the 3C study.
Obesity (Silver Spring) 2012; 20(3):628-35O

Abstract

Whereas global obesity assessed by BMI has been related to asthma risk, little is known as to the potential implication of abdominal adiposity in this relationship. In the elderly, in whom asthma remains poorly studied, abdominal adiposity tends to increase at the expense of muscle mass. The purpose of this study was to investigate the association between abdominal adiposity, assessed by waist circumference (WC), and prevalence and incidence of asthma in a large elderly cohort. Cross-sectional analysis was based on 7,643 participants aged ≥65 years including 592 (7.7%) with lifetime physician-diagnosed asthma. Longitudinal analysis involved 6,267 baseline nonasthmatics followed-up for a period of 4 years, 67 of whom exhibited incident asthma. Baseline WC was categorized according to sex-specific criteria (men/women): <94/80 cm (reference), [94-102[/[80-88[ (abdominal overweight), and ≥102/88 (abdominal obesity). Logistic and Cox regression models estimated asthma risk associated with WC after adjustment for age, sex, educational level, smoking status, BMI, physical ability, dyspnea, chronic bronchitis symptoms and history of cardiovascular disease. At baseline, asthma risk increased with increasing WC independently of BMI and other confounders (adjusted odds ratio (ORa), 95% confidence interval (CI): 1.30, 1.02-1.65 and ORa: 1.76, 1.31-2.36 for abdominal overweight and obesity, respectively). Asthma incidence was related to WC (hazard ratio (HRa), 95% CI: 2.69, 1.21-5.98 and HRa: 3.84, 1.55-9.49, for abdominal overweight and obesity, respectively). Estimates were similar in both sexes. In the elderly, abdominal adiposity was independently associated with increased prevalence and incidence of asthma. Studies aiming to understand the mechanisms involved in the adiposity-asthma link are needed.

Authors+Show Affiliations

INSERM U700, Faculté de Médecine Xavier Bichat, Paris, France. nathalie.leone@inserm.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22016095

Citation

Leone, Nathalie, et al. "Abdominal Obesity and Late-onset Asthma: Cross-sectional and Longitudinal Results: the 3C Study." Obesity (Silver Spring, Md.), vol. 20, no. 3, 2012, pp. 628-35.
Leone N, Courbon D, Berr C, et al. Abdominal obesity and late-onset asthma: cross-sectional and longitudinal results: the 3C study. Obesity (Silver Spring). 2012;20(3):628-35.
Leone, N., Courbon, D., Berr, C., Barberger-Gateau, P., Tzourio, C., Alpérovitch, A., & Zureik, M. (2012). Abdominal obesity and late-onset asthma: cross-sectional and longitudinal results: the 3C study. Obesity (Silver Spring, Md.), 20(3), pp. 628-35. doi:10.1038/oby.2011.308.
Leone N, et al. Abdominal Obesity and Late-onset Asthma: Cross-sectional and Longitudinal Results: the 3C Study. Obesity (Silver Spring). 2012;20(3):628-35. PubMed PMID: 22016095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abdominal obesity and late-onset asthma: cross-sectional and longitudinal results: the 3C study. AU - Leone,Nathalie, AU - Courbon,Dominique, AU - Berr,Claudine, AU - Barberger-Gateau,Pascale, AU - Tzourio,Christophe, AU - Alpérovitch,Annick, AU - Zureik,Mahmoud, Y1 - 2011/10/20/ PY - 2011/10/22/entrez PY - 2011/10/22/pubmed PY - 2012/6/13/medline SP - 628 EP - 35 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 20 IS - 3 N2 - Whereas global obesity assessed by BMI has been related to asthma risk, little is known as to the potential implication of abdominal adiposity in this relationship. In the elderly, in whom asthma remains poorly studied, abdominal adiposity tends to increase at the expense of muscle mass. The purpose of this study was to investigate the association between abdominal adiposity, assessed by waist circumference (WC), and prevalence and incidence of asthma in a large elderly cohort. Cross-sectional analysis was based on 7,643 participants aged ≥65 years including 592 (7.7%) with lifetime physician-diagnosed asthma. Longitudinal analysis involved 6,267 baseline nonasthmatics followed-up for a period of 4 years, 67 of whom exhibited incident asthma. Baseline WC was categorized according to sex-specific criteria (men/women): <94/80 cm (reference), [94-102[/[80-88[ (abdominal overweight), and ≥102/88 (abdominal obesity). Logistic and Cox regression models estimated asthma risk associated with WC after adjustment for age, sex, educational level, smoking status, BMI, physical ability, dyspnea, chronic bronchitis symptoms and history of cardiovascular disease. At baseline, asthma risk increased with increasing WC independently of BMI and other confounders (adjusted odds ratio (ORa), 95% confidence interval (CI): 1.30, 1.02-1.65 and ORa: 1.76, 1.31-2.36 for abdominal overweight and obesity, respectively). Asthma incidence was related to WC (hazard ratio (HRa), 95% CI: 2.69, 1.21-5.98 and HRa: 3.84, 1.55-9.49, for abdominal overweight and obesity, respectively). Estimates were similar in both sexes. In the elderly, abdominal adiposity was independently associated with increased prevalence and incidence of asthma. Studies aiming to understand the mechanisms involved in the adiposity-asthma link are needed. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/22016095/Abdominal_obesity_and_late_onset_asthma:_cross_sectional_and_longitudinal_results:_the_3C_study_ L2 - https://doi.org/10.1038/oby.2011.308 DB - PRIME DP - Unbound Medicine ER -