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Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis.
Am J Respir Crit Care Med. 2012 Jan 01; 185(1):67-76.AJ

Abstract

RATIONALE

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology with a variable and unpredictable course.

OBJECTIVES

The aim of this study was to identify and validate plasma proteins that are predictive of outcome in IPF.

METHODS

Plasma samples were available for 241 patients with IPF (140 derivation and 101 validation). In the derivation cohort, concentrations of 92 proteins were analyzed using a multiplex bead-based immunoassay and concentrations of matrix metalloproteinase (MMP)-7, MMP-1, and surfactant protein D were assessed by ELISA. In the validation cohort concentrations of intercellular adhesion molecule (ICAM)-1, IL-8, and vascular cell adhesion molecule (VCAM)-1 were assessed by bead-based multiplex assay, and S100A12 and MMP-7 by ELISA. Associations of biomarkers with mortality, transplant-free survival, and disease progression were tested in the derivation and validation cohorts using nonparametric methods of survival analysis and the Cox proportional hazards model, and an integrated risk prediction score was derived and tested.

MEASUREMENTS AND MAIN RESULTS

High concentrations of MMP-7, ICAM-1, IL-8, VCAM-1, and S100A12 predicted poor overall survival, poor transplant-free survival, and poor progression-free survival in the derivation cohort. In the independent validation cohort high concentrations of all five were predictive of poor transplant-free survival; MMP-7, ICAM-1, and IL-8 of overall survival; and ICAM-1 of poor progression-free survival. The personal clinical and molecular mortality prediction index derived in the derivation cohort was highly predictive of mortality in the validation cohort.

CONCLUSIONS

Our results suggest that plasma proteins should be evaluated as a tool for prognosis determination in prioritization of patients for lung transplantation and stratification in drug studies.

Authors+Show Affiliations

The Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease, Department of Medicine, University of Pittsburgh Medical Center, NW 628 MUH, 3459 5th Avenue, Pittsburgh, PA 15261, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22016448

Citation

Richards, Thomas J., et al. "Peripheral Blood Proteins Predict Mortality in Idiopathic Pulmonary Fibrosis." American Journal of Respiratory and Critical Care Medicine, vol. 185, no. 1, 2012, pp. 67-76.
Richards TJ, Kaminski N, Baribaud F, et al. Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2012;185(1):67-76.
Richards, T. J., Kaminski, N., Baribaud, F., Flavin, S., Brodmerkel, C., Horowitz, D., Li, K., Choi, J., Vuga, L. J., Lindell, K. O., Klesen, M., Zhang, Y., & Gibson, K. F. (2012). Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine, 185(1), 67-76. https://doi.org/10.1164/rccm.201101-0058OC
Richards TJ, et al. Peripheral Blood Proteins Predict Mortality in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2012 Jan 1;185(1):67-76. PubMed PMID: 22016448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. AU - Richards,Thomas J, AU - Kaminski,Naftali, AU - Baribaud,Fred, AU - Flavin,Susan, AU - Brodmerkel,Carrie, AU - Horowitz,Daniel, AU - Li,Katherine, AU - Choi,Jiin, AU - Vuga,Louis J, AU - Lindell,Kathleen O, AU - Klesen,Melinda, AU - Zhang,Yingze, AU - Gibson,Kevin F, PY - 2011/10/22/entrez PY - 2011/10/22/pubmed PY - 2012/3/6/medline SP - 67 EP - 76 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 185 IS - 1 N2 - RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology with a variable and unpredictable course. OBJECTIVES: The aim of this study was to identify and validate plasma proteins that are predictive of outcome in IPF. METHODS: Plasma samples were available for 241 patients with IPF (140 derivation and 101 validation). In the derivation cohort, concentrations of 92 proteins were analyzed using a multiplex bead-based immunoassay and concentrations of matrix metalloproteinase (MMP)-7, MMP-1, and surfactant protein D were assessed by ELISA. In the validation cohort concentrations of intercellular adhesion molecule (ICAM)-1, IL-8, and vascular cell adhesion molecule (VCAM)-1 were assessed by bead-based multiplex assay, and S100A12 and MMP-7 by ELISA. Associations of biomarkers with mortality, transplant-free survival, and disease progression were tested in the derivation and validation cohorts using nonparametric methods of survival analysis and the Cox proportional hazards model, and an integrated risk prediction score was derived and tested. MEASUREMENTS AND MAIN RESULTS: High concentrations of MMP-7, ICAM-1, IL-8, VCAM-1, and S100A12 predicted poor overall survival, poor transplant-free survival, and poor progression-free survival in the derivation cohort. In the independent validation cohort high concentrations of all five were predictive of poor transplant-free survival; MMP-7, ICAM-1, and IL-8 of overall survival; and ICAM-1 of poor progression-free survival. The personal clinical and molecular mortality prediction index derived in the derivation cohort was highly predictive of mortality in the validation cohort. CONCLUSIONS: Our results suggest that plasma proteins should be evaluated as a tool for prognosis determination in prioritization of patients for lung transplantation and stratification in drug studies. SN - 1535-4970 UR - https://www.unboundmedicine.com/medline/citation/22016448/Peripheral_blood_proteins_predict_mortality_in_idiopathic_pulmonary_fibrosis_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.201101-0058OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -