Tags

Type your tag names separated by a space and hit enter

Bone marrow necrosis secondary to imatinib usage, mimicking spinal metastasis on magnetic resonance imaging and FDG-PET/CT.
J Neurosurg Spine. 2012 Jan; 16(1):57-60.JN

Abstract

Imatinib mesylate has become the treatment of choice for gastrointestinal stromal tumors (GISTs) and has made a revolutionary impact on survival rates. Bone marrow necrosis is a very rare adverse event in malignant GIST. Bone metastases are also rarely encountered in the setting of this disease. The authors report on a patient with malignant GIST who developed a bone lesion, mimicking spinal metastasis on both MR imaging and FDG-PET/CT. Corpectomy and anterior fusion was performed, but the pathology report was consistent with bone marrow necrosis. Radiological and clinical similarities made the distinction between metastasis and bone marrow necrosis challenging for the treating physicians. Instead of radical surgical excision, more conservative methods such as percutaneous or endoscopic bone biopsies may be more useful for pathological confirmation, even though investigations such as MR imaging and FDG-PET/CT indicate metastatic disease.

Authors+Show Affiliations

Departments of Neurosurgery, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22017257

Citation

Aras, Yavuz, et al. "Bone Marrow Necrosis Secondary to Imatinib Usage, Mimicking Spinal Metastasis On Magnetic Resonance Imaging and FDG-PET/CT." Journal of Neurosurgery. Spine, vol. 16, no. 1, 2012, pp. 57-60.
Aras Y, Akcakaya MO, Unal SN, et al. Bone marrow necrosis secondary to imatinib usage, mimicking spinal metastasis on magnetic resonance imaging and FDG-PET/CT. J Neurosurg Spine. 2012;16(1):57-60.
Aras, Y., Akcakaya, M. O., Unal, S. N., Bilgic, B., & Unal, O. F. (2012). Bone marrow necrosis secondary to imatinib usage, mimicking spinal metastasis on magnetic resonance imaging and FDG-PET/CT. Journal of Neurosurgery. Spine, 16(1), 57-60. https://doi.org/10.3171/2011.9.SPINE11401
Aras Y, et al. Bone Marrow Necrosis Secondary to Imatinib Usage, Mimicking Spinal Metastasis On Magnetic Resonance Imaging and FDG-PET/CT. J Neurosurg Spine. 2012;16(1):57-60. PubMed PMID: 22017257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone marrow necrosis secondary to imatinib usage, mimicking spinal metastasis on magnetic resonance imaging and FDG-PET/CT. AU - Aras,Yavuz, AU - Akcakaya,Mehmet Osman, AU - Unal,Seher N, AU - Bilgic,Bilge, AU - Unal,Omer Faruk, Y1 - 2011/10/21/ PY - 2011/10/25/entrez PY - 2011/10/25/pubmed PY - 2012/2/18/medline SP - 57 EP - 60 JF - Journal of neurosurgery. Spine JO - J Neurosurg Spine VL - 16 IS - 1 N2 - Imatinib mesylate has become the treatment of choice for gastrointestinal stromal tumors (GISTs) and has made a revolutionary impact on survival rates. Bone marrow necrosis is a very rare adverse event in malignant GIST. Bone metastases are also rarely encountered in the setting of this disease. The authors report on a patient with malignant GIST who developed a bone lesion, mimicking spinal metastasis on both MR imaging and FDG-PET/CT. Corpectomy and anterior fusion was performed, but the pathology report was consistent with bone marrow necrosis. Radiological and clinical similarities made the distinction between metastasis and bone marrow necrosis challenging for the treating physicians. Instead of radical surgical excision, more conservative methods such as percutaneous or endoscopic bone biopsies may be more useful for pathological confirmation, even though investigations such as MR imaging and FDG-PET/CT indicate metastatic disease. SN - 1547-5646 UR - https://www.unboundmedicine.com/medline/citation/22017257/Bone_marrow_necrosis_secondary_to_imatinib_usage_mimicking_spinal_metastasis_on_magnetic_resonance_imaging_and_FDG_PET/CT_ L2 - https://thejns.org/doi/10.3171/2011.9.SPINE11401 DB - PRIME DP - Unbound Medicine ER -