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Effects of plant sterol esters in skimmed milk and vegetable-fat-enriched milk on serum lipids and non-cholesterol sterols in hypercholesterolaemic subjects: a randomised, placebo-controlled, crossover study.
Br J Nutr. 2012 Jun; 107(12):1766-75.BJ

Abstract

Plant sterol (PS)-supplemented foods are recommended to help in lowering serum LDL-cholesterol (LDL-C). Few studies have examined the efficacy of PS-enriched skimmed milk (SM) or semi-SM enriched with vegetable fat (PS-VFM). There is also insufficient information on factors predictive of LDL-C responses to PS. We examined the effects of PS-SM (0·1 % dairy fat) and PS-VFM (0·1 % dairy fat plus 1·5 % vegetable fat) on serum lipids and non-cholesterol sterols in hypercholesterolaemic individuals. In a placebo-controlled, crossover study, forty-three subjects with LDL-C>1300 mg/l were randomly assigned to three 4-week treatment periods: control SM, PS-SM and PS-VFM, with 500 ml milk with or without 3·4 g PS esters (2 g free PS). Serum concentrations of lipids and non-cholesterol sterols were measured. Compared to control, LDL-C decreased by 8·0 and 7·4 % (P < 0·015, both) in the PS-SM and PS-VFM periods, respectively. Serum lathosterol:cholesterol (C) ratios increased by 11-25 %, while sitosterol:C and campesterol:C ratios increased by 70-120 % with both the PS-fortified milk. Adjusted LDL-C reductions were variably enhanced in participants with basal low serum lathosterol/C or conversely high sitosterol/C and campesterol/C. Subjects with post-treatment serum PS:C ratios above the median showed mean LDL-C changes of - 5·9 to - 10·4 %, compared with 1·7 to - 2·9 % below the median. In conclusion, consumption of 2 g/d of PS as PS-SM and PS-VFM lowered LDL-C in hypercholesterolaemic subjects to a similar extent. Basal and post-treatment changes in markers of cholesterol metabolism indicating low cholesterol synthesis and high cholesterol absorption predicted improved LDL-C responses to PS.

Authors+Show Affiliations

Lipid Clinic, Service of Endocrinology and Nutrition, Institut d'Investigations Biomediques August Pi Sunyer, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22018049

Citation

Casas-Agustench, Patricia, et al. "Effects of Plant Sterol Esters in Skimmed Milk and Vegetable-fat-enriched Milk On Serum Lipids and Non-cholesterol Sterols in Hypercholesterolaemic Subjects: a Randomised, Placebo-controlled, Crossover Study." The British Journal of Nutrition, vol. 107, no. 12, 2012, pp. 1766-75.
Casas-Agustench P, Serra M, Pérez-Heras A, et al. Effects of plant sterol esters in skimmed milk and vegetable-fat-enriched milk on serum lipids and non-cholesterol sterols in hypercholesterolaemic subjects: a randomised, placebo-controlled, crossover study. Br J Nutr. 2012;107(12):1766-75.
Casas-Agustench, P., Serra, M., Pérez-Heras, A., Cofán, M., Pintó, X., Trautwein, E. A., & Ros, E. (2012). Effects of plant sterol esters in skimmed milk and vegetable-fat-enriched milk on serum lipids and non-cholesterol sterols in hypercholesterolaemic subjects: a randomised, placebo-controlled, crossover study. The British Journal of Nutrition, 107(12), 1766-75. https://doi.org/10.1017/S0007114511005162
Casas-Agustench P, et al. Effects of Plant Sterol Esters in Skimmed Milk and Vegetable-fat-enriched Milk On Serum Lipids and Non-cholesterol Sterols in Hypercholesterolaemic Subjects: a Randomised, Placebo-controlled, Crossover Study. Br J Nutr. 2012;107(12):1766-75. PubMed PMID: 22018049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of plant sterol esters in skimmed milk and vegetable-fat-enriched milk on serum lipids and non-cholesterol sterols in hypercholesterolaemic subjects: a randomised, placebo-controlled, crossover study. AU - Casas-Agustench,Patricia, AU - Serra,Mercè, AU - Pérez-Heras,Ana, AU - Cofán,Montserrat, AU - Pintó,Xavier, AU - Trautwein,Elke A, AU - Ros,Emilio, Y1 - 2011/10/10/ PY - 2011/10/25/entrez PY - 2011/10/25/pubmed PY - 2012/8/21/medline SP - 1766 EP - 75 JF - The British journal of nutrition JO - Br J Nutr VL - 107 IS - 12 N2 - Plant sterol (PS)-supplemented foods are recommended to help in lowering serum LDL-cholesterol (LDL-C). Few studies have examined the efficacy of PS-enriched skimmed milk (SM) or semi-SM enriched with vegetable fat (PS-VFM). There is also insufficient information on factors predictive of LDL-C responses to PS. We examined the effects of PS-SM (0·1 % dairy fat) and PS-VFM (0·1 % dairy fat plus 1·5 % vegetable fat) on serum lipids and non-cholesterol sterols in hypercholesterolaemic individuals. In a placebo-controlled, crossover study, forty-three subjects with LDL-C>1300 mg/l were randomly assigned to three 4-week treatment periods: control SM, PS-SM and PS-VFM, with 500 ml milk with or without 3·4 g PS esters (2 g free PS). Serum concentrations of lipids and non-cholesterol sterols were measured. Compared to control, LDL-C decreased by 8·0 and 7·4 % (P < 0·015, both) in the PS-SM and PS-VFM periods, respectively. Serum lathosterol:cholesterol (C) ratios increased by 11-25 %, while sitosterol:C and campesterol:C ratios increased by 70-120 % with both the PS-fortified milk. Adjusted LDL-C reductions were variably enhanced in participants with basal low serum lathosterol/C or conversely high sitosterol/C and campesterol/C. Subjects with post-treatment serum PS:C ratios above the median showed mean LDL-C changes of - 5·9 to - 10·4 %, compared with 1·7 to - 2·9 % below the median. In conclusion, consumption of 2 g/d of PS as PS-SM and PS-VFM lowered LDL-C in hypercholesterolaemic subjects to a similar extent. Basal and post-treatment changes in markers of cholesterol metabolism indicating low cholesterol synthesis and high cholesterol absorption predicted improved LDL-C responses to PS. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/22018049/Effects_of_plant_sterol_esters_in_skimmed_milk_and_vegetable_fat_enriched_milk_on_serum_lipids_and_non_cholesterol_sterols_in_hypercholesterolaemic_subjects:_a_randomised_placebo_controlled_crossover_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511005162/type/journal_article DB - PRIME DP - Unbound Medicine ER -