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Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.
Physiol Behav. 2012 Feb 01; 105(3):683-92.PB

Abstract

We aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system, Ca(2+) influx, cell viability and electroencephalography (EEG) records in the rat. Thirty two rats were equally divided into four different groups namely group A1: Cage control, group A2: Sham control, group B: 2.45 GHz EMR, group C: 2.45 GHz EMR+melatonin. Groups B and C were exposed to 2.45 GHz EMR during 60 min/day for 30 days. End of the experiments, EEG records and the brain cortex and DRG samples were taken. Lipid peroxidation (LP), cell viability and cytosolic Ca(2+) values in DRG neurons were higher in group B than in groups A1 and A2 although their concentrations were increased by melatonin, 2-aminoethyldiphenyl borinate (2-APB), diltiazem and verapamil supplementation. Spike numbers of EEG records in group C were lower than in group B. Brain cortex vitamin E concentration was higher in group C than in group B. In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45 GHz-induced increase Ca(2+) influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca(2+) channels.

Authors+Show Affiliations

Department of Biophysics, Medicine Faculty, Süleyman Demirel University, Isparta, Turkey. mnaziroglu@med.sdu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22019785

Citation

Nazıroğlu, M, et al. "Melatonin Modulates Wireless (2.45 GHz)-induced Oxidative Injury Through TRPM2 and Voltage Gated Ca(2+) Channels in Brain and Dorsal Root Ganglion in Rat." Physiology & Behavior, vol. 105, no. 3, 2012, pp. 683-92.
Nazıroğlu M, Çelik Ö, Özgül C, et al. Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat. Physiol Behav. 2012;105(3):683-92.
Nazıroğlu, M., Çelik, Ö., Özgül, C., Çiğ, B., Doğan, S., Bal, R., Gümral, N., Rodríguez, A. B., & Pariente, J. A. (2012). Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat. Physiology & Behavior, 105(3), 683-92. https://doi.org/10.1016/j.physbeh.2011.10.005
Nazıroğlu M, et al. Melatonin Modulates Wireless (2.45 GHz)-induced Oxidative Injury Through TRPM2 and Voltage Gated Ca(2+) Channels in Brain and Dorsal Root Ganglion in Rat. Physiol Behav. 2012 Feb 1;105(3):683-92. PubMed PMID: 22019785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat. AU - Nazıroğlu,M, AU - Çelik,Ö, AU - Özgül,C, AU - Çiğ,B, AU - Doğan,S, AU - Bal,R, AU - Gümral,N, AU - Rodríguez,A B, AU - Pariente,J A, Y1 - 2011/10/12/ PY - 2011/08/09/received PY - 2011/10/04/revised PY - 2011/10/05/accepted PY - 2011/10/25/entrez PY - 2011/10/25/pubmed PY - 2012/4/17/medline SP - 683 EP - 92 JF - Physiology & behavior JO - Physiol Behav VL - 105 IS - 3 N2 - We aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system, Ca(2+) influx, cell viability and electroencephalography (EEG) records in the rat. Thirty two rats were equally divided into four different groups namely group A1: Cage control, group A2: Sham control, group B: 2.45 GHz EMR, group C: 2.45 GHz EMR+melatonin. Groups B and C were exposed to 2.45 GHz EMR during 60 min/day for 30 days. End of the experiments, EEG records and the brain cortex and DRG samples were taken. Lipid peroxidation (LP), cell viability and cytosolic Ca(2+) values in DRG neurons were higher in group B than in groups A1 and A2 although their concentrations were increased by melatonin, 2-aminoethyldiphenyl borinate (2-APB), diltiazem and verapamil supplementation. Spike numbers of EEG records in group C were lower than in group B. Brain cortex vitamin E concentration was higher in group C than in group B. In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45 GHz-induced increase Ca(2+) influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca(2+) channels. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/22019785/Melatonin_modulates_wireless__2_45_GHz__induced_oxidative_injury_through_TRPM2_and_voltage_gated_Ca_2+__channels_in_brain_and_dorsal_root_ganglion_in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(11)00482-3 DB - PRIME DP - Unbound Medicine ER -