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Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat.
Physiol Behav. 2012 Feb 01; 105(3):683-92.PB

Abstract

We aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system, Ca(2+) influx, cell viability and electroencephalography (EEG) records in the rat. Thirty two rats were equally divided into four different groups namely group A1: Cage control, group A2: Sham control, group B: 2.45 GHz EMR, group C: 2.45 GHz EMR+melatonin. Groups B and C were exposed to 2.45 GHz EMR during 60 min/day for 30 days. End of the experiments, EEG records and the brain cortex and DRG samples were taken. Lipid peroxidation (LP), cell viability and cytosolic Ca(2+) values in DRG neurons were higher in group B than in groups A1 and A2 although their concentrations were increased by melatonin, 2-aminoethyldiphenyl borinate (2-APB), diltiazem and verapamil supplementation. Spike numbers of EEG records in group C were lower than in group B. Brain cortex vitamin E concentration was higher in group C than in group B. In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45 GHz-induced increase Ca(2+) influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca(2+) channels.

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Authors+Show Affiliations

Nazıroğlu M
Department of Biophysics, Medicine Faculty, Süleyman Demirel University, Isparta, Turkey. mnaziroglu@med.sdu.edu.tr
Çelik Ö
No affiliation info available
Özgül C
No affiliation info available
Çiğ B
No affiliation info available
Doğan S
No affiliation info available
Bal R
No affiliation info available
Gümral N
No affiliation info available
Rodríguez AB
No affiliation info available
Pariente JA
No affiliation info available

MeSH

AnimalsBrainCalciumCalcium Channel BlockersCalcium ChannelsElectroencephalographyElectromagnetic RadiationGanglia, SpinalGlutathioneGlutathione PeroxidaseHydrogen PeroxideLipid PeroxidationMaleMelatoninMembrane PotentialsNeuronsOxidative StressPatch-Clamp TechniquesRatsRats, WistarTRPM Cation Channels

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22019785

Citation

Nazıroğlu, M, et al. "Melatonin Modulates Wireless (2.45 GHz)-induced Oxidative Injury Through TRPM2 and Voltage Gated Ca(2+) Channels in Brain and Dorsal Root Ganglion in Rat." Physiology & Behavior, vol. 105, no. 3, 2012, pp. 683-92.
Nazıroğlu M, Çelik Ö, Özgül C, et al. Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat. Physiol Behav. 2012;105(3):683-92.
Nazıroğlu, M., Çelik, Ö., Özgül, C., Çiğ, B., Doğan, S., Bal, R., Gümral, N., Rodríguez, A. B., & Pariente, J. A. (2012). Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat. Physiology & Behavior, 105(3), 683-92. https://doi.org/10.1016/j.physbeh.2011.10.005
Nazıroğlu M, et al. Melatonin Modulates Wireless (2.45 GHz)-induced Oxidative Injury Through TRPM2 and Voltage Gated Ca(2+) Channels in Brain and Dorsal Root Ganglion in Rat. Physiol Behav. 2012 Feb 1;105(3):683-92. PubMed PMID: 22019785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca(2+) channels in brain and dorsal root ganglion in rat. AU - Nazıroğlu,M, AU - Çelik,Ö, AU - Özgül,C, AU - Çiğ,B, AU - Doğan,S, AU - Bal,R, AU - Gümral,N, AU - Rodríguez,A B, AU - Pariente,J A, Y1 - 2011/10/12/ PY - 2011/08/09/received PY - 2011/10/04/revised PY - 2011/10/05/accepted PY - 2011/10/25/entrez PY - 2011/10/25/pubmed PY - 2012/4/17/medline SP - 683 EP - 92 JF - Physiology & behavior JO - Physiol Behav VL - 105 IS - 3 N2 - We aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system, Ca(2+) influx, cell viability and electroencephalography (EEG) records in the rat. Thirty two rats were equally divided into four different groups namely group A1: Cage control, group A2: Sham control, group B: 2.45 GHz EMR, group C: 2.45 GHz EMR+melatonin. Groups B and C were exposed to 2.45 GHz EMR during 60 min/day for 30 days. End of the experiments, EEG records and the brain cortex and DRG samples were taken. Lipid peroxidation (LP), cell viability and cytosolic Ca(2+) values in DRG neurons were higher in group B than in groups A1 and A2 although their concentrations were increased by melatonin, 2-aminoethyldiphenyl borinate (2-APB), diltiazem and verapamil supplementation. Spike numbers of EEG records in group C were lower than in group B. Brain cortex vitamin E concentration was higher in group C than in group B. In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45 GHz-induced increase Ca(2+) influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca(2+) channels. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/22019785/Melatonin_modulates_wireless__2_45_GHz__induced_oxidative_injury_through_TRPM2_and_voltage_gated_Ca_2+__channels_in_brain_and_dorsal_root_ganglion_in_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(11)00482-3 DB - PRIME DP - Unbound Medicine ER -