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Protective immunity elicited by a pseudotyped baculovirus-mediated bivalent H5N1 influenza vaccine.
Antiviral Res. 2011 Dec; 92(3):493-6.AR

Abstract

The development of novel H5N1 influenza vaccines to elicit a broad immune response is a priority in veterinary and human public health. In this report, a baculovirus vector was used to construct bivalent recombinant baculovirus vaccine encoding H5N1 influenza virus hemagglutinin proteins (BV-HAs) from clade 2.3.4 and clade 9 influenza viruses. Mice immunized with 5×10(7) IFU BV-HAs developed significantly high levels of H5-specific neutralizing antibodies and cellular immunity that conferred 100% protection against infection with H5N1 influenza viruses. This study suggests that baculovirus-delivered multi-hemagglutinin proteins might serve as a candidate vaccine for the prevention of pre-pandemic and pandemic H5N1 influenza viruses.

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Authors+Show Affiliations

Wu Q
Division of Animal Infectious Diseases, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Xiao S
No affiliation info available
Fan H
No affiliation info available
Li Y
No affiliation info available
Xu J
No affiliation info available
Li Z
No affiliation info available
Lu W
No affiliation info available
Su X
No affiliation info available
Zou W
No affiliation info available
Jin M
No affiliation info available
Chen H
No affiliation info available
Fang L
No affiliation info available

MeSH

AnimalsAntibodies, ViralBaculoviridaeFemaleGenetic VectorsHemagglutinin Glycoproteins, Influenza VirusImmunity, CellularInfluenza A Virus, H5N1 SubtypeInfluenza VaccinesMiceMice, Inbred BALB COrthomyxoviridae InfectionsSurvival Analysis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22020305

Citation

Wu, Qunfeng, et al. "Protective Immunity Elicited By a Pseudotyped Baculovirus-mediated Bivalent H5N1 Influenza Vaccine." Antiviral Research, vol. 92, no. 3, 2011, pp. 493-6.
Wu Q, Xiao S, Fan H, et al. Protective immunity elicited by a pseudotyped baculovirus-mediated bivalent H5N1 influenza vaccine. Antiviral Res. 2011;92(3):493-6.
Wu, Q., Xiao, S., Fan, H., Li, Y., Xu, J., Li, Z., Lu, W., Su, X., Zou, W., Jin, M., Chen, H., & Fang, L. (2011). Protective immunity elicited by a pseudotyped baculovirus-mediated bivalent H5N1 influenza vaccine. Antiviral Research, 92(3), 493-6. https://doi.org/10.1016/j.antiviral.2011.10.001
Wu Q, et al. Protective Immunity Elicited By a Pseudotyped Baculovirus-mediated Bivalent H5N1 Influenza Vaccine. Antiviral Res. 2011;92(3):493-6. PubMed PMID: 22020305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective immunity elicited by a pseudotyped baculovirus-mediated bivalent H5N1 influenza vaccine. AU - Wu,Qunfeng, AU - Xiao,Shaobo, AU - Fan,Huiying, AU - Li,Yang, AU - Xu,Jinfang, AU - Li,Zhen, AU - Lu,Wei, AU - Su,Xiaoyue, AU - Zou,Wei, AU - Jin,Meilin, AU - Chen,Huanchun, AU - Fang,Liurong, Y1 - 2011/10/12/ PY - 2011/08/03/received PY - 2011/10/04/revised PY - 2011/10/04/accepted PY - 2011/10/25/entrez PY - 2011/10/25/pubmed PY - 2012/3/23/medline SP - 493 EP - 6 JF - Antiviral research JO - Antiviral Res VL - 92 IS - 3 N2 - The development of novel H5N1 influenza vaccines to elicit a broad immune response is a priority in veterinary and human public health. In this report, a baculovirus vector was used to construct bivalent recombinant baculovirus vaccine encoding H5N1 influenza virus hemagglutinin proteins (BV-HAs) from clade 2.3.4 and clade 9 influenza viruses. Mice immunized with 5×10(7) IFU BV-HAs developed significantly high levels of H5-specific neutralizing antibodies and cellular immunity that conferred 100% protection against infection with H5N1 influenza viruses. This study suggests that baculovirus-delivered multi-hemagglutinin proteins might serve as a candidate vaccine for the prevention of pre-pandemic and pandemic H5N1 influenza viruses. SN - 1872-9096 UR - https://www.unboundmedicine.com/medline/citation/22020305/Protective_immunity_elicited_by_a_pseudotyped_baculovirus_mediated_bivalent_H5N1_influenza_vaccine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-3542(11)00451-7 DB - PRIME DP - Unbound Medicine ER -