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Electrode position and the clinical outcome after bilateral subthalamic nucleus stimulation.
J Korean Med Sci. 2011 Oct; 26(10):1344-55.JK

Abstract

We compared the surgical outcome with electrode positions after bilateral subthalamic nucleus (STN) stimulation surgery for Parkinson's disease. Fifty-seven patients treated with bilateral STN stimulations were included in this study. Electrode positions were determined in the fused images of preoperative MRI and postoperative CT taken at six months after surgery. The patients were divided into three groups: group I, both electrodes in the STN; group II, only one electrode in the STN; group III, neither electrode in the STN. Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr stage, and activities of daily living scores significantly improved at 6 and 12 months after STN stimulation in both group I and II. The off-time UPDRS III speech subscore significantly improved (1.6 ± 0.7 at baseline vs 1.3 ± 0.8 at 6 and 12 months, P < 0.01) with least L-dopa equivalent daily dose (LEDD) (844.6 ± 364.1 mg/day at baseline; 279.4 ± 274.6 mg/day at 6 months; and 276.0 ± 301.6 mg/day at 12 months, P < 0.001) at 6 and 12 months after STN deep brain stimulation (DBS) in the group I. Our findings suggest that the better symptom relief including speech with a reduced LEDD is expected in the patients whose electrodes are accurately positioned in both STN.

Authors+Show Affiliations

Movement Disorder Center and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22022189

Citation

Paek, Sun Ha, et al. "Electrode Position and the Clinical Outcome After Bilateral Subthalamic Nucleus Stimulation." Journal of Korean Medical Science, vol. 26, no. 10, 2011, pp. 1344-55.
Paek SH, Lee JY, Kim HJ, et al. Electrode position and the clinical outcome after bilateral subthalamic nucleus stimulation. J Korean Med Sci. 2011;26(10):1344-55.
Paek, S. H., Lee, J. Y., Kim, H. J., Kang, D., Lim, Y. H., Kim, M. R., Kim, C., Jeon, B. S., & Kim, D. G. (2011). Electrode position and the clinical outcome after bilateral subthalamic nucleus stimulation. Journal of Korean Medical Science, 26(10), 1344-55. https://doi.org/10.3346/jkms.2011.26.10.1344
Paek SH, et al. Electrode Position and the Clinical Outcome After Bilateral Subthalamic Nucleus Stimulation. J Korean Med Sci. 2011;26(10):1344-55. PubMed PMID: 22022189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrode position and the clinical outcome after bilateral subthalamic nucleus stimulation. AU - Paek,Sun Ha, AU - Lee,Jee-Young, AU - Kim,Han-Joon, AU - Kang,Daehee, AU - Lim,Yong Hoon, AU - Kim,Mi Ryoung, AU - Kim,Cheolyoung, AU - Jeon,Beom Seok, AU - Kim,Dong Gyu, Y1 - 2011/10/01/ PY - 2011/03/21/received PY - 2011/08/29/accepted PY - 2011/10/25/entrez PY - 2011/10/25/pubmed PY - 2012/2/16/medline KW - Bilateral STN Stimulation KW - Clinical Outcome KW - Electrode Position KW - Fused Images KW - Parkinson Disease SP - 1344 EP - 55 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 26 IS - 10 N2 - We compared the surgical outcome with electrode positions after bilateral subthalamic nucleus (STN) stimulation surgery for Parkinson's disease. Fifty-seven patients treated with bilateral STN stimulations were included in this study. Electrode positions were determined in the fused images of preoperative MRI and postoperative CT taken at six months after surgery. The patients were divided into three groups: group I, both electrodes in the STN; group II, only one electrode in the STN; group III, neither electrode in the STN. Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr stage, and activities of daily living scores significantly improved at 6 and 12 months after STN stimulation in both group I and II. The off-time UPDRS III speech subscore significantly improved (1.6 ± 0.7 at baseline vs 1.3 ± 0.8 at 6 and 12 months, P < 0.01) with least L-dopa equivalent daily dose (LEDD) (844.6 ± 364.1 mg/day at baseline; 279.4 ± 274.6 mg/day at 6 months; and 276.0 ± 301.6 mg/day at 12 months, P < 0.001) at 6 and 12 months after STN deep brain stimulation (DBS) in the group I. Our findings suggest that the better symptom relief including speech with a reduced LEDD is expected in the patients whose electrodes are accurately positioned in both STN. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/22022189/Electrode_position_and_the_clinical_outcome_after_bilateral_subthalamic_nucleus_stimulation_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2011.26.10.1344 DB - PRIME DP - Unbound Medicine ER -