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Effect of hypertonic vs isotonic saline solution on responses to sublethal Escherichia coli endotoxemia in horses.
Am J Vet Res. 1990 Jul; 51(7):999-1007.AJ

Abstract

Cardiovascular responses to sublethal endotoxin infusion (Escherichia coli, 50 micrograms/ml in lactated Ringer solution at 100 ml/h until pulmonary arterial pressure increased by 10 mm of Hg) were measured 2 times in 5 standing horses. In a 2-period crossover experimental design, horses were either administered hypertonic (2,400 mosm/kg of body weight, IV) or isotonic (300 mosm/kg, IV) NaCl solution after endotoxin challenges. Each solution was administered at a dose of 5 ml/kg (infusion rate, 80 ml/min). Complete data sets (mean arterial, central venous, and pulmonary arterial pressures, pulmonary arterial blood temperature, cardiac output, total peripheral vascular resistance, heart rate, plasma osmolality, plasma concentration of Na, K, Cl, and total protein, blood lactate concentration, and PCV) were collected at 0 (baseline, before endotoxin infusion), 0.25, 1, 1.5, 2, 2.5, 3, 3.5, 4, and 4.5 hours after initiation of the endotoxin infusion. Blood constituents alone were measured at 0.5 hour and cardiovascular variables alone were evaluated at 0.75 hour. By 0.25 hour, endotoxin infusion was completed, a data set was collected, and saline infusion was initiated. By 0.75 hour, saline solutions had been completely administered. Mean (+/- SEM) cardiac output decreased (99.76 +/- 3.66 to 72.7 +/- 2.35 ml/min/kg) and total peripheral resistance (1.0 +/- 0.047 to 1.37 +/- 0.049 mm of Hg/ml/min/kg) and pulmonary arterial pressure (33.4 +/- 0.86 to 58.3 +/- 1.18 mm of Hg) increased for both trials by 0.25 hour after initiation of the endotoxin infusion and prior to fluid administration. For the remainder of the protocol, cardiac output was increased and total peripheral resistance was decreased during the hypertonic, compared with the isotonic, saline trial.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge 70803.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2202242

Citation

Bertone, J J., et al. "Effect of Hypertonic Vs Isotonic Saline Solution On Responses to Sublethal Escherichia Coli Endotoxemia in Horses." American Journal of Veterinary Research, vol. 51, no. 7, 1990, pp. 999-1007.
Bertone JJ, Gossett KA, Shoemaker KE, et al. Effect of hypertonic vs isotonic saline solution on responses to sublethal Escherichia coli endotoxemia in horses. Am J Vet Res. 1990;51(7):999-1007.
Bertone, J. J., Gossett, K. A., Shoemaker, K. E., Bertone, A. L., & Schneiter, H. L. (1990). Effect of hypertonic vs isotonic saline solution on responses to sublethal Escherichia coli endotoxemia in horses. American Journal of Veterinary Research, 51(7), 999-1007.
Bertone JJ, et al. Effect of Hypertonic Vs Isotonic Saline Solution On Responses to Sublethal Escherichia Coli Endotoxemia in Horses. Am J Vet Res. 1990;51(7):999-1007. PubMed PMID: 2202242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of hypertonic vs isotonic saline solution on responses to sublethal Escherichia coli endotoxemia in horses. AU - Bertone,J J, AU - Gossett,K A, AU - Shoemaker,K E, AU - Bertone,A L, AU - Schneiter,H L, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 999 EP - 1007 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 51 IS - 7 N2 - Cardiovascular responses to sublethal endotoxin infusion (Escherichia coli, 50 micrograms/ml in lactated Ringer solution at 100 ml/h until pulmonary arterial pressure increased by 10 mm of Hg) were measured 2 times in 5 standing horses. In a 2-period crossover experimental design, horses were either administered hypertonic (2,400 mosm/kg of body weight, IV) or isotonic (300 mosm/kg, IV) NaCl solution after endotoxin challenges. Each solution was administered at a dose of 5 ml/kg (infusion rate, 80 ml/min). Complete data sets (mean arterial, central venous, and pulmonary arterial pressures, pulmonary arterial blood temperature, cardiac output, total peripheral vascular resistance, heart rate, plasma osmolality, plasma concentration of Na, K, Cl, and total protein, blood lactate concentration, and PCV) were collected at 0 (baseline, before endotoxin infusion), 0.25, 1, 1.5, 2, 2.5, 3, 3.5, 4, and 4.5 hours after initiation of the endotoxin infusion. Blood constituents alone were measured at 0.5 hour and cardiovascular variables alone were evaluated at 0.75 hour. By 0.25 hour, endotoxin infusion was completed, a data set was collected, and saline infusion was initiated. By 0.75 hour, saline solutions had been completely administered. Mean (+/- SEM) cardiac output decreased (99.76 +/- 3.66 to 72.7 +/- 2.35 ml/min/kg) and total peripheral resistance (1.0 +/- 0.047 to 1.37 +/- 0.049 mm of Hg/ml/min/kg) and pulmonary arterial pressure (33.4 +/- 0.86 to 58.3 +/- 1.18 mm of Hg) increased for both trials by 0.25 hour after initiation of the endotoxin infusion and prior to fluid administration. For the remainder of the protocol, cardiac output was increased and total peripheral resistance was decreased during the hypertonic, compared with the isotonic, saline trial.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/2202242/Effect_of_hypertonic_vs_isotonic_saline_solution_on_responses_to_sublethal_Escherichia_coli_endotoxemia_in_horses_ L2 - https://medlineplus.gov/ecoliinfections.html DB - PRIME DP - Unbound Medicine ER -