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Inhibitory potential of the leaves and berries of Myrtus communis L. (myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions.
Int J Food Sci Nutr. 2012 Jun; 63(4):387-92.IJ

Abstract

The dichloromethane (DCM), acetone, ethyl acetate and methanol extracts of the leaves and berries of Myrtus communis L. were screened against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase (TYRO), the enzymes linked to neurodegenerative diseases, at 200 μg ml⁻¹. Antioxidant activity was tested using radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and N,N- dimethyl-p-phenylenediamine (DMPD) radicals, metal chelation capacity, ferric-reducing antioxidant power (FRAP) and phosphomolybdenum-reducing antioxidant power (PRAP) assays. Total phenol and flavonoid quantification of the extracts was calculated spectrophotometrically. The extracts showed a moderate AChE (17.49 ± 3.99% to 43.15 ± 1.55%) and TYRO inhibition (4.48 ± 1.50% to 40.53 ± 0.47%). The leaf extracts were ineffective against BChE, while the berry extracts displayed inhibition between 21.83 ± 3.82% and 36.80 ± 2.00%. The polar extracts exerted remarkable scavenging effect against DPPH and DMPD and also in the FRAP assay, where the DCM extract of the berries had the best metal chelation capacity (79.29 ± 1.14%). This is the first study that demonstrates in vitro neuroprotective effects of myrtle.

Authors+Show Affiliations

Department of Forest Products Chemistry, Faculty of Forestry, Bartin University, 74100 Bartin, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22022834

Citation

Tumen, Ibrahim, et al. "Inhibitory Potential of the Leaves and Berries of Myrtus Communis L. (myrtle) Against Enzymes Linked to Neurodegenerative Diseases and Their Antioxidant Actions." International Journal of Food Sciences and Nutrition, vol. 63, no. 4, 2012, pp. 387-92.
Tumen I, Senol FS, Orhan IE. Inhibitory potential of the leaves and berries of Myrtus communis L. (myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions. Int J Food Sci Nutr. 2012;63(4):387-92.
Tumen, I., Senol, F. S., & Orhan, I. E. (2012). Inhibitory potential of the leaves and berries of Myrtus communis L. (myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions. International Journal of Food Sciences and Nutrition, 63(4), 387-92. https://doi.org/10.3109/09637486.2011.629178
Tumen I, Senol FS, Orhan IE. Inhibitory Potential of the Leaves and Berries of Myrtus Communis L. (myrtle) Against Enzymes Linked to Neurodegenerative Diseases and Their Antioxidant Actions. Int J Food Sci Nutr. 2012;63(4):387-92. PubMed PMID: 22022834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory potential of the leaves and berries of Myrtus communis L. (myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions. AU - Tumen,Ibrahim, AU - Senol,Fatma Sezer, AU - Orhan,Ilkay Erdogan, Y1 - 2011/10/24/ PY - 2011/10/26/entrez PY - 2011/10/26/pubmed PY - 2012/9/5/medline SP - 387 EP - 92 JF - International journal of food sciences and nutrition JO - Int J Food Sci Nutr VL - 63 IS - 4 N2 - The dichloromethane (DCM), acetone, ethyl acetate and methanol extracts of the leaves and berries of Myrtus communis L. were screened against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase (TYRO), the enzymes linked to neurodegenerative diseases, at 200 μg ml⁻¹. Antioxidant activity was tested using radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and N,N- dimethyl-p-phenylenediamine (DMPD) radicals, metal chelation capacity, ferric-reducing antioxidant power (FRAP) and phosphomolybdenum-reducing antioxidant power (PRAP) assays. Total phenol and flavonoid quantification of the extracts was calculated spectrophotometrically. The extracts showed a moderate AChE (17.49 ± 3.99% to 43.15 ± 1.55%) and TYRO inhibition (4.48 ± 1.50% to 40.53 ± 0.47%). The leaf extracts were ineffective against BChE, while the berry extracts displayed inhibition between 21.83 ± 3.82% and 36.80 ± 2.00%. The polar extracts exerted remarkable scavenging effect against DPPH and DMPD and also in the FRAP assay, where the DCM extract of the berries had the best metal chelation capacity (79.29 ± 1.14%). This is the first study that demonstrates in vitro neuroprotective effects of myrtle. SN - 1465-3478 UR - https://www.unboundmedicine.com/medline/citation/22022834/Inhibitory_potential_of_the_leaves_and_berries_of_Myrtus_communis_L___myrtle__against_enzymes_linked_to_neurodegenerative_diseases_and_their_antioxidant_actions_ L2 - https://www.tandfonline.com/doi/full/10.3109/09637486.2011.629178 DB - PRIME DP - Unbound Medicine ER -