Tags

Type your tag names separated by a space and hit enter

The relationship between retinol-binding protein 4 levels, insulin resistance, androgen hormones and polycystic ovary syndrome.
Scand J Clin Lab Invest. 2012 Feb; 72(1):39-44.SJ

Abstract

BACKGROUND

Retinol-binding protein 4 (RPB4), a 21-kDa peptide, is a recently identified adipokine that may contribute to the pathogenesis of polycystic ovary syndrome (PCOS). The aim of this study was to explore the association between serum RBP4 levels, androgen hormones and insulin resistance (IR) in women with PCOS.

METHODS

In this case-control study, 75 PCOS patients and 53 age- and body mass index (BMI)-matched control subjects referred to the Zanjan Metabolic Disease Research Center were enrolled. Serum RBP4 was measured using an enzyme-linked immunosorbent assay. BMI, waist circumference (WC), fasting levels of glucose, lipid profiles and insulin were also measured. A homeostatic model assessment of insulin resistance (HOMA-IR) value was used to determine the level of insulin resistance.

RESULTS

PCOS cases had significantly higher serum RBP4 and insulin levels than control subjects (44130 ± 12760 vs. 32980 ± 9560 μg/L, p < 0.001, and 11790 ± 11480 vs. 7890 ± 4300 μU/L, p < 0.05, respectively), in univariable analysis. RBP4 showed a positive correlation with serum testosterone (r = 0.62, p < 0.0001), dehydroepiandrosterone sulfate (r = 0.45, p < 0.0001) and the waist circumference (r = 0.37, p < 0.001) of PCOS patients but not with other measured clinical and biochemical variables. However, no correlation was observed between serum RBP4 levels and HOMA-IR in all studied subjects. A final logistic regression analysis demonstrated that testosterone and dehydroepiandrosterone sulfate are independently associated with PCOS.

CONCLUSION

These findings indicate that RBP4 is not independently associated with PCOS. The elevation of RBP4 levels in PCOS women might be influenced by androgen hormones. Further prospective studies are needed to clarify molecular mechanisms.

Authors+Show Affiliations

Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22023042

Citation

Mellati, Ali Awsat, et al. "The Relationship Between Retinol-binding Protein 4 Levels, Insulin Resistance, Androgen Hormones and Polycystic Ovary Syndrome." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 72, no. 1, 2012, pp. 39-44.
Mellati AA, Sharifi F, Sajadinejad M, et al. The relationship between retinol-binding protein 4 levels, insulin resistance, androgen hormones and polycystic ovary syndrome. Scand J Clin Lab Invest. 2012;72(1):39-44.
Mellati, A. A., Sharifi, F., Sajadinejad, M., Sohrabi, D., & Mazloomzadeh, S. (2012). The relationship between retinol-binding protein 4 levels, insulin resistance, androgen hormones and polycystic ovary syndrome. Scandinavian Journal of Clinical and Laboratory Investigation, 72(1), 39-44. https://doi.org/10.3109/00365513.2011.626071
Mellati AA, et al. The Relationship Between Retinol-binding Protein 4 Levels, Insulin Resistance, Androgen Hormones and Polycystic Ovary Syndrome. Scand J Clin Lab Invest. 2012;72(1):39-44. PubMed PMID: 22023042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between retinol-binding protein 4 levels, insulin resistance, androgen hormones and polycystic ovary syndrome. AU - Mellati,Ali Awsat, AU - Sharifi,Faranak, AU - Sajadinejad,Mohsen, AU - Sohrabi,Davood, AU - Mazloomzadeh,Saeideh, Y1 - 2011/10/24/ PY - 2011/10/26/entrez PY - 2011/10/26/pubmed PY - 2012/5/19/medline SP - 39 EP - 44 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 72 IS - 1 N2 - BACKGROUND: Retinol-binding protein 4 (RPB4), a 21-kDa peptide, is a recently identified adipokine that may contribute to the pathogenesis of polycystic ovary syndrome (PCOS). The aim of this study was to explore the association between serum RBP4 levels, androgen hormones and insulin resistance (IR) in women with PCOS. METHODS: In this case-control study, 75 PCOS patients and 53 age- and body mass index (BMI)-matched control subjects referred to the Zanjan Metabolic Disease Research Center were enrolled. Serum RBP4 was measured using an enzyme-linked immunosorbent assay. BMI, waist circumference (WC), fasting levels of glucose, lipid profiles and insulin were also measured. A homeostatic model assessment of insulin resistance (HOMA-IR) value was used to determine the level of insulin resistance. RESULTS: PCOS cases had significantly higher serum RBP4 and insulin levels than control subjects (44130 ± 12760 vs. 32980 ± 9560 μg/L, p < 0.001, and 11790 ± 11480 vs. 7890 ± 4300 μU/L, p < 0.05, respectively), in univariable analysis. RBP4 showed a positive correlation with serum testosterone (r = 0.62, p < 0.0001), dehydroepiandrosterone sulfate (r = 0.45, p < 0.0001) and the waist circumference (r = 0.37, p < 0.001) of PCOS patients but not with other measured clinical and biochemical variables. However, no correlation was observed between serum RBP4 levels and HOMA-IR in all studied subjects. A final logistic regression analysis demonstrated that testosterone and dehydroepiandrosterone sulfate are independently associated with PCOS. CONCLUSION: These findings indicate that RBP4 is not independently associated with PCOS. The elevation of RBP4 levels in PCOS women might be influenced by androgen hormones. Further prospective studies are needed to clarify molecular mechanisms. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/22023042/The_relationship_between_retinol_binding_protein_4_levels_insulin_resistance_androgen_hormones_and_polycystic_ovary_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365513.2011.626071 DB - PRIME DP - Unbound Medicine ER -