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Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature.
J Clin Pharm Ther. 2012 Jun; 37(3):370-2.JC

Abstract

WHAT IS KNOWN AND OBJECTIVE

Aripiprazole has a low risk of extrapyramidal symptoms. Switching to aripiprazole has been reported to improve tardive dyskinesia caused by other medications. The authors report a case and review previous reports of dystonia and dyskinesia associated with aripiprazole.

CASE SUMMARY

We present a case of a 22-year-old man with schizophrenia who experienced dyskinesia and dystonia associated with aripiprazole. Switching from olanzapine to aripiprazole resulted in worsening dyskinesia and new onset of dystonia. The patient's dyskinesia and dystonia improved after switching from aripiprazole to quetiapine therapy.

WHAT IS NEW AND CONCLUSION

There were several previous case reports on dyskinesia and dystonia associated with aripiprazole medication. The risk factors for tardive dyskinesia include older age and female sex. However, our case was a male patient who was younger compared with the previous cases and so should have been less at risk for dyskinesia in comparison with the previous cases. The effects of aripiprazole can include tardive movement disorders. Dyskinesia, dystonia and psychotic symptoms were improved with relatively small dose of quetiapine in this case. Whether some second-generation antipsychotics are more effective than others in the treatment of tardive dyskinesia remains unclear.

Authors+Show Affiliations

Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

22023382

Citation

Ono, S, et al. "Improvement of Tardive Dyskinesia and Dystonia Associated With Aripiprazole Following a Switch to Quetiapine: Case Report and Review of the Literature." Journal of Clinical Pharmacy and Therapeutics, vol. 37, no. 3, 2012, pp. 370-2.
Ono S, Suzuki Y, Shindo M, et al. Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature. J Clin Pharm Ther. 2012;37(3):370-2.
Ono, S., Suzuki, Y., Shindo, M., Endo, T., Fukui, N., Sugai, T., & Someya, T. (2012). Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature. Journal of Clinical Pharmacy and Therapeutics, 37(3), 370-2. https://doi.org/10.1111/j.1365-2710.2011.01290.x
Ono S, et al. Improvement of Tardive Dyskinesia and Dystonia Associated With Aripiprazole Following a Switch to Quetiapine: Case Report and Review of the Literature. J Clin Pharm Ther. 2012;37(3):370-2. PubMed PMID: 22023382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature. AU - Ono,S, AU - Suzuki,Y, AU - Shindo,M, AU - Endo,T, AU - Fukui,N, AU - Sugai,T, AU - Someya,T, Y1 - 2011/10/24/ PY - 2011/10/26/entrez PY - 2011/10/26/pubmed PY - 2012/10/10/medline SP - 370 EP - 2 JF - Journal of clinical pharmacy and therapeutics JO - J Clin Pharm Ther VL - 37 IS - 3 N2 - WHAT IS KNOWN AND OBJECTIVE: Aripiprazole has a low risk of extrapyramidal symptoms. Switching to aripiprazole has been reported to improve tardive dyskinesia caused by other medications. The authors report a case and review previous reports of dystonia and dyskinesia associated with aripiprazole. CASE SUMMARY: We present a case of a 22-year-old man with schizophrenia who experienced dyskinesia and dystonia associated with aripiprazole. Switching from olanzapine to aripiprazole resulted in worsening dyskinesia and new onset of dystonia. The patient's dyskinesia and dystonia improved after switching from aripiprazole to quetiapine therapy. WHAT IS NEW AND CONCLUSION: There were several previous case reports on dyskinesia and dystonia associated with aripiprazole medication. The risk factors for tardive dyskinesia include older age and female sex. However, our case was a male patient who was younger compared with the previous cases and so should have been less at risk for dyskinesia in comparison with the previous cases. The effects of aripiprazole can include tardive movement disorders. Dyskinesia, dystonia and psychotic symptoms were improved with relatively small dose of quetiapine in this case. Whether some second-generation antipsychotics are more effective than others in the treatment of tardive dyskinesia remains unclear. SN - 1365-2710 UR - https://www.unboundmedicine.com/medline/citation/22023382/Improvement_of_tardive_dyskinesia_and_dystonia_associated_with_aripiprazole_following_a_switch_to_quetiapine:_case_report_and_review_of_the_literature_ L2 - https://doi.org/10.1111/j.1365-2710.2011.01290.x DB - PRIME DP - Unbound Medicine ER -