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The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers.
Allergy 2012; 67(2):248-56A

Abstract

BACKGROUND

Exposure to high levels of house dust mite (HDM) allergens is associated with the development of allergic sensitization to HDM, a risk factor for the development of asthma, rhinitis, and allergic dermatitis. We studied the effect of an early intervention with mite-impermeable mattress covers on HDM allergen levels and the development of asthma and mite allergy throughout the first 8 years of life.

METHODS

High-risk children (allergic mother) were prenatally recruited and randomly allocated to two groups receiving mite allergen-impermeable (n = 416) and placebo mattress covers (n = 394) or no intervention (n = 472). Asthma and allergies were assessed yearly by questionnaire. Specific immunoglobulin E and bronchial hyper-responsiveness were measured at the age of 8 years. Mattress dust samples collected at different time points were analyzed for HDM allergens.

RESULTS

At the age of 8 years, levels of HDM allergen Der f1 but not Der p1 were lower in the active than the placebo mattress cover group. In repeated measures analyses, we found a temporary decreased risk of asthma symptoms at the age of 2 years in the intervention group compared to the placebo group and a temporary association between higher HDM allergen exposure at the age of 3 months and more asthma symptoms.

CONCLUSION

Early intervention with mite-impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization.

Authors+Show Affiliations

Institute for Risk Assessment Sciences, Utrecht University, The Netherlands. u.gehring@uu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22023655

Citation

Gehring, U, et al. "The 8-year Follow-up of the PIAMA Intervention Study Assessing the Effect of Mite-impermeable Mattress Covers." Allergy, vol. 67, no. 2, 2012, pp. 248-56.
Gehring U, de Jongste JC, Kerkhof M, et al. The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers. Allergy. 2012;67(2):248-56.
Gehring, U., de Jongste, J. C., Kerkhof, M., Oldewening, M., Postma, D., van Strien, R. T., ... Brunekreef, B. (2012). The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers. Allergy, 67(2), pp. 248-56. doi:10.1111/j.1398-9995.2011.02739.x.
Gehring U, et al. The 8-year Follow-up of the PIAMA Intervention Study Assessing the Effect of Mite-impermeable Mattress Covers. Allergy. 2012;67(2):248-56. PubMed PMID: 22023655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers. AU - Gehring,U, AU - de Jongste,J C, AU - Kerkhof,M, AU - Oldewening,M, AU - Postma,D, AU - van Strien,R T, AU - Wijga,A H, AU - Willers,S M, AU - Wolse,A, AU - Gerritsen,J, AU - Smit,H A, AU - Brunekreef,B, Y1 - 2011/10/25/ PY - 2011/10/26/entrez PY - 2011/10/26/pubmed PY - 2012/5/9/medline SP - 248 EP - 56 JF - Allergy JO - Allergy VL - 67 IS - 2 N2 - BACKGROUND: Exposure to high levels of house dust mite (HDM) allergens is associated with the development of allergic sensitization to HDM, a risk factor for the development of asthma, rhinitis, and allergic dermatitis. We studied the effect of an early intervention with mite-impermeable mattress covers on HDM allergen levels and the development of asthma and mite allergy throughout the first 8 years of life. METHODS: High-risk children (allergic mother) were prenatally recruited and randomly allocated to two groups receiving mite allergen-impermeable (n = 416) and placebo mattress covers (n = 394) or no intervention (n = 472). Asthma and allergies were assessed yearly by questionnaire. Specific immunoglobulin E and bronchial hyper-responsiveness were measured at the age of 8 years. Mattress dust samples collected at different time points were analyzed for HDM allergens. RESULTS: At the age of 8 years, levels of HDM allergen Der f1 but not Der p1 were lower in the active than the placebo mattress cover group. In repeated measures analyses, we found a temporary decreased risk of asthma symptoms at the age of 2 years in the intervention group compared to the placebo group and a temporary association between higher HDM allergen exposure at the age of 3 months and more asthma symptoms. CONCLUSION: Early intervention with mite-impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/22023655/The_8_year_follow_up_of_the_PIAMA_intervention_study_assessing_the_effect_of_mite_impermeable_mattress_covers_ L2 - https://doi.org/10.1111/j.1398-9995.2011.02739.x DB - PRIME DP - Unbound Medicine ER -