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[Hypervitaminemia B12 (high level of cobalamin): physiopathology, role and interest in clinical practice].
Presse Med. 2011 Dec; 40(12 Pt 1):1120-7.PM

Abstract

Hypervitaminemia B12 or high serum level of cobalamin B12 is a frequent and clinical underestimated abnormality. Clinically, it can be sometimes paradoxically accompanied by signs of deficiency reflecting a functional deficit in relation to qualitative abnormalities related to defects in tissue uptake and action of vitamin B12. Etiological profile of hypervitaminemias B12 has mostly serious disease entities and for which early diagnosis is crucial to the plan rather than prognostic. These entities are represented mainly by solid malignancies, hematological malignancies and liver diseases. This reflects the potential significance that may have the dosage of vitamin B12 as an early marker of diagnosis of these diseases. Codified approach is needed to determine the potential indications of the search for a hypervitaminemia B12 and practice what to do to pass before the discovery of a high serum level of cobalamin.

Authors+Show Affiliations

Hôpitaux universitaires de Strasbourg, clinique médicale B, service de médecine interne, diabète et maladies métaboliques, 67091 Strasbourg cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

22023830

Citation

Serraj, Khalid, et al. "[Hypervitaminemia B12 (high Level of Cobalamin): Physiopathology, Role and Interest in Clinical Practice]." Presse Medicale (Paris, France : 1983), vol. 40, no. 12 Pt 1, 2011, pp. 1120-7.
Serraj K, Mecili M, Housni I, et al. [Hypervitaminemia B12 (high level of cobalamin): physiopathology, role and interest in clinical practice]. Presse Med. 2011;40(12 Pt 1):1120-7.
Serraj, K., Mecili, M., Housni, I., & Andrès, E. (2011). [Hypervitaminemia B12 (high level of cobalamin): physiopathology, role and interest in clinical practice]. Presse Medicale (Paris, France : 1983), 40(12 Pt 1), 1120-7. https://doi.org/10.1016/j.lpm.2011.08.010
Serraj K, et al. [Hypervitaminemia B12 (high Level of Cobalamin): Physiopathology, Role and Interest in Clinical Practice]. Presse Med. 2011;40(12 Pt 1):1120-7. PubMed PMID: 22023830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hypervitaminemia B12 (high level of cobalamin): physiopathology, role and interest in clinical practice]. AU - Serraj,Khalid, AU - Mecili,Mustapha, AU - Housni,Ibrahim, AU - Andrès,Emmanuel, Y1 - 2011/10/22/ PY - 2011/08/12/received PY - 2011/08/29/accepted PY - 2011/10/26/entrez PY - 2011/10/26/pubmed PY - 2012/1/27/medline SP - 1120 EP - 7 JF - Presse medicale (Paris, France : 1983) JO - Presse Med VL - 40 IS - 12 Pt 1 N2 - Hypervitaminemia B12 or high serum level of cobalamin B12 is a frequent and clinical underestimated abnormality. Clinically, it can be sometimes paradoxically accompanied by signs of deficiency reflecting a functional deficit in relation to qualitative abnormalities related to defects in tissue uptake and action of vitamin B12. Etiological profile of hypervitaminemias B12 has mostly serious disease entities and for which early diagnosis is crucial to the plan rather than prognostic. These entities are represented mainly by solid malignancies, hematological malignancies and liver diseases. This reflects the potential significance that may have the dosage of vitamin B12 as an early marker of diagnosis of these diseases. Codified approach is needed to determine the potential indications of the search for a hypervitaminemia B12 and practice what to do to pass before the discovery of a high serum level of cobalamin. SN - 2213-0276 UR - https://www.unboundmedicine.com/medline/citation/22023830/[Hypervitaminemia_B12__high_level_of_cobalamin_:_physiopathology_role_and_interest_in_clinical_practice]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0755-4982(11)00469-6 DB - PRIME DP - Unbound Medicine ER -